Research ExplorerPublicationsNeutrophil Extracellular Traps Initiate Gallstone Formation

Neutrophil Extracellular Traps Initiate Gallstone Formation

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Neutrophil Extracellular Traps Initiate Gallstone Formation. / Muñoz, Luis E; Boeltz, Sebastian; Bilyy, Rostyslav; Schauer, Christine; Mahajan, Aparna; Widulin, Navena; Grüneboom, Anika; Herrmann, Irmgard; Boada, Edgyda; Rauh, Manfred; Krenn, Veit; Biermann, Mona H C; Podolska, Malgorzata J; Hahn, Jonas; Knopf, Jasmin; Maueröder, Christian; Paryzhak, Solomiya; Dumych, Tetiana; Zhao, Yi; Neurath, Markus F; Hoffmann, Markus H; Fuchs, Tobias A; Leppkes, Moritz; Schett, Georg; Herrmann, Martin.

In: IMMUNITY, Vol. 51, No. 3, 17.09.2019, p. 443-450.e4.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Muñoz, LE, Boeltz, S, Bilyy, R, Schauer, C, Mahajan, A, Widulin, N, Grüneboom, A, Herrmann, I, Boada, E, Rauh, M, Krenn, V, Biermann, MHC, Podolska, MJ, Hahn, J, Knopf, J, Maueröder, C, Paryzhak, S, Dumych, T, Zhao, Y, Neurath, MF, Hoffmann, MH, Fuchs, TA, Leppkes, M, Schett, G & Herrmann, M 2019, 'Neutrophil Extracellular Traps Initiate Gallstone Formation', IMMUNITY, vol. 51, no. 3, pp. 443-450.e4. https://doi.org/10.1016/j.immuni.2019.07.002

APA

Muñoz, L. E., Boeltz, S., Bilyy, R., Schauer, C., Mahajan, A., Widulin, N., Grüneboom, A., Herrmann, I., Boada, E., Rauh, M., Krenn, V., Biermann, M. H. C., Podolska, M. J., Hahn, J., Knopf, J., Maueröder, C., Paryzhak, S., Dumych, T., Zhao, Y., ... Herrmann, M. (2019). Neutrophil Extracellular Traps Initiate Gallstone Formation. IMMUNITY, 51(3), 443-450.e4. https://doi.org/10.1016/j.immuni.2019.07.002

Vancouver

Muñoz LE, Boeltz S, Bilyy R, Schauer C, Mahajan A, Widulin N et al. Neutrophil Extracellular Traps Initiate Gallstone Formation. IMMUNITY. 2019 Sep 17;51(3):443-450.e4. https://doi.org/10.1016/j.immuni.2019.07.002

Bibtex

@article{ef8ab3cb257045cab4f19bd72287d0f1,
title = "Neutrophil Extracellular Traps Initiate Gallstone Formation",
abstract = "The presence of gallstones (cholelithiasis) is a highly prevalent and severe disease and one of the leading causes of hospital admissions worldwide. Due to its substantial health impact, we investigated the biological mechanisms that lead to the formation and growth of gallstones. We show that gallstone assembly essentially requires neutrophil extracellular traps (NETs). We found consistent evidence for the presence of NETs in human and murine gallstones and describe an immune-mediated process requiring activation of the innate immune system for the formation and growth of gallstones. Targeting NET formation via inhibition of peptidyl arginine deiminase type 4 or abrogation of reactive oxygen species (ROS) production, as well as damping of neutrophils by metoprolol, effectively inhibit gallstone formation in vivo. Our results show that after the physicochemical process of crystal formation, NETs foster their assembly into larger aggregates and finally gallstones. These insights provide a feasible therapeutic concept to prevent cholelithiasis in patients at risk.",
author = "Mu{\~n}oz, {Luis E} and Sebastian Boeltz and Rostyslav Bilyy and Christine Schauer and Aparna Mahajan and Navena Widulin and Anika Gr{\"u}neboom and Irmgard Herrmann and Edgyda Boada and Manfred Rauh and Veit Krenn and Biermann, {Mona H C} and Podolska, {Malgorzata J} and Jonas Hahn and Jasmin Knopf and Christian Mauer{\"o}der and Solomiya Paryzhak and Tetiana Dumych and Yi Zhao and Neurath, {Markus F} and Hoffmann, {Markus H} and Fuchs, {Tobias A} and Moritz Leppkes and Georg Schett and Martin Herrmann",
note = "Copyright {\textcopyright} 2019 Elsevier Inc. All rights reserved.",
year = "2019",
month = sep,
day = "17",
doi = "10.1016/j.immuni.2019.07.002",
language = "English",
volume = "51",
pages = "443--450.e4",
journal = "IMMUNITY",
issn = "1074-7613",
publisher = "Cell Press",
number = "3",

}

RIS

TY - JOUR

T1 - Neutrophil Extracellular Traps Initiate Gallstone Formation

AU - Muñoz, Luis E

AU - Boeltz, Sebastian

AU - Bilyy, Rostyslav

AU - Schauer, Christine

AU - Mahajan, Aparna

AU - Widulin, Navena

AU - Grüneboom, Anika

AU - Herrmann, Irmgard

AU - Boada, Edgyda

AU - Rauh, Manfred

AU - Krenn, Veit

AU - Biermann, Mona H C

AU - Podolska, Malgorzata J

AU - Hahn, Jonas

AU - Knopf, Jasmin

AU - Maueröder, Christian

AU - Paryzhak, Solomiya

AU - Dumych, Tetiana

AU - Zhao, Yi

AU - Neurath, Markus F

AU - Hoffmann, Markus H

AU - Fuchs, Tobias A

AU - Leppkes, Moritz

AU - Schett, Georg

AU - Herrmann, Martin

N1 - Copyright © 2019 Elsevier Inc. All rights reserved.

PY - 2019/9/17

Y1 - 2019/9/17

N2 - The presence of gallstones (cholelithiasis) is a highly prevalent and severe disease and one of the leading causes of hospital admissions worldwide. Due to its substantial health impact, we investigated the biological mechanisms that lead to the formation and growth of gallstones. We show that gallstone assembly essentially requires neutrophil extracellular traps (NETs). We found consistent evidence for the presence of NETs in human and murine gallstones and describe an immune-mediated process requiring activation of the innate immune system for the formation and growth of gallstones. Targeting NET formation via inhibition of peptidyl arginine deiminase type 4 or abrogation of reactive oxygen species (ROS) production, as well as damping of neutrophils by metoprolol, effectively inhibit gallstone formation in vivo. Our results show that after the physicochemical process of crystal formation, NETs foster their assembly into larger aggregates and finally gallstones. These insights provide a feasible therapeutic concept to prevent cholelithiasis in patients at risk.

AB - The presence of gallstones (cholelithiasis) is a highly prevalent and severe disease and one of the leading causes of hospital admissions worldwide. Due to its substantial health impact, we investigated the biological mechanisms that lead to the formation and growth of gallstones. We show that gallstone assembly essentially requires neutrophil extracellular traps (NETs). We found consistent evidence for the presence of NETs in human and murine gallstones and describe an immune-mediated process requiring activation of the innate immune system for the formation and growth of gallstones. Targeting NET formation via inhibition of peptidyl arginine deiminase type 4 or abrogation of reactive oxygen species (ROS) production, as well as damping of neutrophils by metoprolol, effectively inhibit gallstone formation in vivo. Our results show that after the physicochemical process of crystal formation, NETs foster their assembly into larger aggregates and finally gallstones. These insights provide a feasible therapeutic concept to prevent cholelithiasis in patients at risk.

U2 - 10.1016/j.immuni.2019.07.002

DO - 10.1016/j.immuni.2019.07.002

M3 - SCORING: Journal article

C2 - 31422870

VL - 51

SP - 443-450.e4

JO - IMMUNITY

JF - IMMUNITY

SN - 1074-7613

IS - 3

ER -