Neuronal DNA Methyltransferases: Epigenetic Mediators between Synaptic Activity and Gene Expression?

Gonca Bayraktar; Michael R Kreutz

doi:10.1177/1073858417707457

Neuronal DNA Methyltransferases

Standard

Neuronal DNA Methyltransferases : Epigenetic Mediators between Synaptic Activity and Gene Expression? / Bayraktar, Gonca; Kreutz, Michael R.

In: NEUROSCIENTIST, 17.05.2017, p. 1073858417707457.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bayraktar, G & Kreutz, MR 2017, 'Neuronal DNA Methyltransferases: Epigenetic Mediators between Synaptic Activity and Gene Expression?', NEUROSCIENTIST, pp. 1073858417707457. https://doi.org/10.1177/1073858417707457

APA

Bayraktar, G., & Kreutz, M. R. (2017). Neuronal DNA Methyltransferases: Epigenetic Mediators between Synaptic Activity and Gene Expression? NEUROSCIENTIST, 1073858417707457. https://doi.org/10.1177/1073858417707457

Vancouver

Bayraktar G, Kreutz MR. Neuronal DNA Methyltransferases: Epigenetic Mediators between Synaptic Activity and Gene Expression? NEUROSCIENTIST. 2017 May 17;1073858417707457. https://doi.org/10.1177/1073858417707457

Bibtex

@article{c407aa85d8964dcc8b3ffb12b5d70a20,

title = "Neuronal DNA Methyltransferases: Epigenetic Mediators between Synaptic Activity and Gene Expression?",

abstract = "DNMT3A and 3B are the main de novo DNA methyltransferases (DNMTs) in the brain that introduce new methylation marks to non-methylated DNA in postmitotic neurons. DNA methylation is a key epigenetic mark that is known to regulate important cellular processes in neuronal development and brain plasticity. Accumulating evidence disclosed rapid and dynamic changes in DNA methylation of plasticity-relevant genes that are important for learning and memory formation. To understand how DNMTs contribute to brain function and how they are regulated by neuronal activity is a prerequisite for a deeper appreciation of activity-dependent gene expression in health and disease. This review discusses the functional role of de novo methyltransferases and in particular DNMT3A1 in the adult brain with special emphasis on synaptic plasticity, memory formation, and brain disorders.",

keywords = "Journal Article",

author = "Gonca Bayraktar and Kreutz, {Michael R}",

year = "2017",

month = may,

day = "17",

doi = "10.1177/1073858417707457",

language = "English",

pages = "1073858417707457",

journal = "NEUROSCIENTIST",

issn = "1073-8584",

publisher = "SAGE Publications",

}

RIS

TY - JOUR

T1 - Neuronal DNA Methyltransferases

T2 - Epigenetic Mediators between Synaptic Activity and Gene Expression?

AU - Bayraktar, Gonca

AU - Kreutz, Michael R

PY - 2017/5/17

Y1 - 2017/5/17

N2 - DNMT3A and 3B are the main de novo DNA methyltransferases (DNMTs) in the brain that introduce new methylation marks to non-methylated DNA in postmitotic neurons. DNA methylation is a key epigenetic mark that is known to regulate important cellular processes in neuronal development and brain plasticity. Accumulating evidence disclosed rapid and dynamic changes in DNA methylation of plasticity-relevant genes that are important for learning and memory formation. To understand how DNMTs contribute to brain function and how they are regulated by neuronal activity is a prerequisite for a deeper appreciation of activity-dependent gene expression in health and disease. This review discusses the functional role of de novo methyltransferases and in particular DNMT3A1 in the adult brain with special emphasis on synaptic plasticity, memory formation, and brain disorders.

AB - DNMT3A and 3B are the main de novo DNA methyltransferases (DNMTs) in the brain that introduce new methylation marks to non-methylated DNA in postmitotic neurons. DNA methylation is a key epigenetic mark that is known to regulate important cellular processes in neuronal development and brain plasticity. Accumulating evidence disclosed rapid and dynamic changes in DNA methylation of plasticity-relevant genes that are important for learning and memory formation. To understand how DNMTs contribute to brain function and how they are regulated by neuronal activity is a prerequisite for a deeper appreciation of activity-dependent gene expression in health and disease. This review discusses the functional role of de novo methyltransferases and in particular DNMT3A1 in the adult brain with special emphasis on synaptic plasticity, memory formation, and brain disorders.

KW - Journal Article

U2 - 10.1177/1073858417707457

DO - 10.1177/1073858417707457

M3 - SCORING: Journal article

C2 - 28513272

SP - 1073858417707457

JO - NEUROSCIENTIST

JF - NEUROSCIENTIST

SN - 1073-8584

ER -