Neuronal differentiation of cultured human NTERA-2cl.D1 cells leads to increased expression of synapsins.
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Neuronal differentiation of cultured human NTERA-2cl.D1 cells leads to increased expression of synapsins. / Leypoldt, Frank; Flajolet, Marc; Methner, Axel.
In: NEUROSCI LETT, Vol. 324, No. 1, 1, 2002, p. 37-40.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Neuronal differentiation of cultured human NTERA-2cl.D1 cells leads to increased expression of synapsins.
AU - Leypoldt, Frank
AU - Flajolet, Marc
AU - Methner, Axel
PY - 2002
Y1 - 2002
N2 - The synapsin family consists of three neuronal-specific phosphoproteins associated with dynamic reorganization of the neuronal cytoskeleton. Synapsin I and II are implicated in axonal and synaptic differentiation, formation and maintenance, whereas the function of synapsin III is not as well defined. We report a significant transcriptional upregulation of all three synapsins (synapsin I, 2.1-fold; synapsin II, 2.6-fold; and synapsin III, 5.5-fold) by retinoic acid-induced differentiation of NTera-2cl.D1 cells, a human paradigm for neuronal differentiation. The observed stronger regulation of synapsin III might be due to still active neurite elongation and a rather early state of presynaptic maturation at the time-point investigated, as synapsin III was previously found to be highly enriched in growth cones and during early synaptic development.
AB - The synapsin family consists of three neuronal-specific phosphoproteins associated with dynamic reorganization of the neuronal cytoskeleton. Synapsin I and II are implicated in axonal and synaptic differentiation, formation and maintenance, whereas the function of synapsin III is not as well defined. We report a significant transcriptional upregulation of all three synapsins (synapsin I, 2.1-fold; synapsin II, 2.6-fold; and synapsin III, 5.5-fold) by retinoic acid-induced differentiation of NTera-2cl.D1 cells, a human paradigm for neuronal differentiation. The observed stronger regulation of synapsin III might be due to still active neurite elongation and a rather early state of presynaptic maturation at the time-point investigated, as synapsin III was previously found to be highly enriched in growth cones and during early synaptic development.
M3 - SCORING: Zeitschriftenaufsatz
VL - 324
SP - 37
EP - 40
JO - NEUROSCI LETT
JF - NEUROSCI LETT
SN - 0304-3940
IS - 1
M1 - 1
ER -
