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Neuroimmunoendocrine circuitry of the 'brain-skin connection'

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Neuroimmunoendocrine circuitry of the 'brain-skin connection'. / Paus, Ralf; Theoharides, Theoharis C; Arck, Petra Clara.

In: TRENDS IMMUNOL, Vol. 27, No. 1, 01.2006, p. 32-9.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Paus, R, Theoharides, TC & Arck, PC 2006, 'Neuroimmunoendocrine circuitry of the 'brain-skin connection'', TRENDS IMMUNOL, vol. 27, no. 1, pp. 32-9. https://doi.org/10.1016/j.it.2005.10.002

APA

Paus, R., Theoharides, T. C., & Arck, P. C. (2006). Neuroimmunoendocrine circuitry of the 'brain-skin connection'. TRENDS IMMUNOL, 27(1), 32-9. https://doi.org/10.1016/j.it.2005.10.002

Vancouver

Paus R, Theoharides TC, Arck PC. Neuroimmunoendocrine circuitry of the 'brain-skin connection'. TRENDS IMMUNOL. 2006 Jan;27(1):32-9. https://doi.org/10.1016/j.it.2005.10.002

Bibtex

@article{506482c42930453f90c4c58b04d59d63,
title = "Neuroimmunoendocrine circuitry of the 'brain-skin connection'",
abstract = "The skin offers an ideally suited, clinically relevant model for studying the crossroads between peripheral and systemic responses to stress. A 'brain-skin connection' with local neuroimmunoendocrine circuitry underlies the pathogenesis of allergic and inflammatory skin diseases, triggered or aggravated by stress. In stressed mice, corticotropin-releasing hormone, nerve growth factor, neurotensin, substance P and mast cells are recruited hierarchically to induce neurogenic skin inflammation, which inhibits hair growth. The hair follicle is both a target and a source for immunomodulatory stress mediators, and has an equivalent of the hypothalamus-pituitary-adrenal axis. Thus, the skin and its appendages enable the study of complex neuroimmunoendocrine responses that peripheral tissues launch upon stress exposure, as a basis for identifying new targets for therapeutic stress intervention.",
keywords = "Animals, Brain/immunology, Hair Follicle/cytology, Humans, Neurons/immunology, Neurosecretory Systems, Skin/immunology, Stress, Physiological/immunology",
author = "Ralf Paus and Theoharides, {Theoharis C} and Arck, {Petra Clara}",
year = "2006",
month = jan,
doi = "10.1016/j.it.2005.10.002",
language = "English",
volume = "27",
pages = "32--9",
journal = "TRENDS IMMUNOL",
issn = "1471-4906",
publisher = "Elsevier Limited",
number = "1",

}

RIS

TY - JOUR

T1 - Neuroimmunoendocrine circuitry of the 'brain-skin connection'

AU - Paus, Ralf

AU - Theoharides, Theoharis C

AU - Arck, Petra Clara

PY - 2006/1

Y1 - 2006/1

N2 - The skin offers an ideally suited, clinically relevant model for studying the crossroads between peripheral and systemic responses to stress. A 'brain-skin connection' with local neuroimmunoendocrine circuitry underlies the pathogenesis of allergic and inflammatory skin diseases, triggered or aggravated by stress. In stressed mice, corticotropin-releasing hormone, nerve growth factor, neurotensin, substance P and mast cells are recruited hierarchically to induce neurogenic skin inflammation, which inhibits hair growth. The hair follicle is both a target and a source for immunomodulatory stress mediators, and has an equivalent of the hypothalamus-pituitary-adrenal axis. Thus, the skin and its appendages enable the study of complex neuroimmunoendocrine responses that peripheral tissues launch upon stress exposure, as a basis for identifying new targets for therapeutic stress intervention.

AB - The skin offers an ideally suited, clinically relevant model for studying the crossroads between peripheral and systemic responses to stress. A 'brain-skin connection' with local neuroimmunoendocrine circuitry underlies the pathogenesis of allergic and inflammatory skin diseases, triggered or aggravated by stress. In stressed mice, corticotropin-releasing hormone, nerve growth factor, neurotensin, substance P and mast cells are recruited hierarchically to induce neurogenic skin inflammation, which inhibits hair growth. The hair follicle is both a target and a source for immunomodulatory stress mediators, and has an equivalent of the hypothalamus-pituitary-adrenal axis. Thus, the skin and its appendages enable the study of complex neuroimmunoendocrine responses that peripheral tissues launch upon stress exposure, as a basis for identifying new targets for therapeutic stress intervention.

KW - Animals

KW - Brain/immunology

KW - Hair Follicle/cytology

KW - Humans

KW - Neurons/immunology

KW - Neurosecretory Systems

KW - Skin/immunology

KW - Stress, Physiological/immunology

U2 - 10.1016/j.it.2005.10.002

DO - 10.1016/j.it.2005.10.002

M3 - SCORING: Review article

C2 - 16269267

VL - 27

SP - 32

EP - 39

JO - TRENDS IMMUNOL

JF - TRENDS IMMUNOL

SN - 1471-4906

IS - 1

ER -