Neuroimaging as a tool to investigate how cognitive factors influence analgesic drug outcomes.
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Neuroimaging as a tool to investigate how cognitive factors influence analgesic drug outcomes. / Bingel, Ulrike; Tracey, Irene; Wiech, Katja.
In: NEUROSCI LETT, Vol. 520, No. 2, 2, 2012, p. 149-155.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Neuroimaging as a tool to investigate how cognitive factors influence analgesic drug outcomes.
AU - Bingel, Ulrike
AU - Tracey, Irene
AU - Wiech, Katja
PY - 2012
Y1 - 2012
N2 - The observation that cognitive factors such as beliefs and expectations not only modulate the perception of pain, but also the therapeutic benefit and adverse effects of any pharmacological treatment is not new. However, the contribution of cognitive factors to pharmacotherapy is still poorly understood and far from being systematically exploited to maximize treatment outcome. Recent insights into placebo and nocebo phenomena and their underlying neurobiological mechanisms have, however, rekindled the interest in interactions between pharmacological effects and cognitive factors. In this review, we argue that modern non-invasive neuroimaging techniques exploring structure and function of the brain as well as neurochemical processes can aid in understanding these potential interactions at a more fundamental level. Taking pain as an example, we portrait recent advances in this field and discuss basic science and clinical implications.
AB - The observation that cognitive factors such as beliefs and expectations not only modulate the perception of pain, but also the therapeutic benefit and adverse effects of any pharmacological treatment is not new. However, the contribution of cognitive factors to pharmacotherapy is still poorly understood and far from being systematically exploited to maximize treatment outcome. Recent insights into placebo and nocebo phenomena and their underlying neurobiological mechanisms have, however, rekindled the interest in interactions between pharmacological effects and cognitive factors. In this review, we argue that modern non-invasive neuroimaging techniques exploring structure and function of the brain as well as neurochemical processes can aid in understanding these potential interactions at a more fundamental level. Taking pain as an example, we portrait recent advances in this field and discuss basic science and clinical implications.
KW - Humans
KW - Magnetic Resonance Imaging
KW - Neuroimaging
KW - Cognition
KW - Prefrontal Cortex/physiopathology
KW - Analgesics/adverse effects/pharmacology/therapeutic use
KW - Brain/drug effects/physiopathology
KW - Pain/drug therapy/physiopathology/psychology
KW - Pain Perception
KW - Humans
KW - Magnetic Resonance Imaging
KW - Neuroimaging
KW - Cognition
KW - Prefrontal Cortex/physiopathology
KW - Analgesics/adverse effects/pharmacology/therapeutic use
KW - Brain/drug effects/physiopathology
KW - Pain/drug therapy/physiopathology/psychology
KW - Pain Perception
M3 - SCORING: Journal article
VL - 520
SP - 149
EP - 155
JO - NEUROSCI LETT
JF - NEUROSCI LETT
SN - 0304-3940
IS - 2
M1 - 2
ER -
