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Neurogenesis in substantia nigra of parkinsonian brains?

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Neurogenesis in substantia nigra of parkinsonian brains? / Arias-Carrión, Oscar; Yamada, Elizabeth; Freundlieb, Nils; Djufri, Miriam; Maurer, Lukas; Hermanns, Guido; Ipach, Bastian; Chiu, Wei-Hua; Steiner, Corinna; Oertel, Wolfgang H; Höglinger, Günter U.

In: J NEURAL TRANSM-SUPP, No. 73, 01.01.2009, p. 279-85.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Arias-Carrión, O, Yamada, E, Freundlieb, N, Djufri, M, Maurer, L, Hermanns, G, Ipach, B, Chiu, W-H, Steiner, C, Oertel, WH & Höglinger, GU 2009, 'Neurogenesis in substantia nigra of parkinsonian brains?', J NEURAL TRANSM-SUPP, no. 73, pp. 279-85.

APA

Arias-Carrión, O., Yamada, E., Freundlieb, N., Djufri, M., Maurer, L., Hermanns, G., Ipach, B., Chiu, W-H., Steiner, C., Oertel, W. H., & Höglinger, G. U. (2009). Neurogenesis in substantia nigra of parkinsonian brains? J NEURAL TRANSM-SUPP, (73), 279-85.

Vancouver

Arias-Carrión O, Yamada E, Freundlieb N, Djufri M, Maurer L, Hermanns G et al. Neurogenesis in substantia nigra of parkinsonian brains? J NEURAL TRANSM-SUPP. 2009 Jan 1;(73):279-85.

Bibtex

@article{f22903481c144e37b23205a0c26681b4,
title = "Neurogenesis in substantia nigra of parkinsonian brains?",
abstract = "The clinical motor dysfunction in Parkinson's disease is primarily the consequence of a progressive degeneration of dopaminergic neurons in the substantia nigra of the nigrostriatal pathway. The degeneration of this tract provokes a depletion of dopamine in the striatum, where it is required as a permissive factor for normal motor function. Despite intense investigations, no effective therapy is available to prevent the onset or to halt the progression of the neuronal cell loss. Therefore, recent years have seen research into the mechanisms of endogenous repair processes occurring in the adult brain, particularly in the substantia nigra. Neurogenesis occurs in the adult brain in a constitutive manner under physiological circumstances within two regions: the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. In contrast to these two so-called neurogenic areas, the remainder of the brain is considered to be primarily nonneurogenic in nature, implying that no new neurons are produced there under normal conditions. The occurrence of adult neurogenesis in the substantia nigra under the pathological conditions of Parkinson's disease, however, remains controversial. Here, we review the published evidence of whether adult neurogenesis exists or not within the substantia nigra, where dopaminergic neurons are lost in Parkinson's disease.",
keywords = "Animals, Humans, Models, Biological, Neurogenesis, Neurons, Parkinson Disease, Substantia Nigra",
author = "Oscar Arias-Carri{\'o}n and Elizabeth Yamada and Nils Freundlieb and Miriam Djufri and Lukas Maurer and Guido Hermanns and Bastian Ipach and Wei-Hua Chiu and Corinna Steiner and Oertel, {Wolfgang H} and H{\"o}glinger, {G{\"u}nter U}",
year = "2009",
month = jan,
day = "1",
language = "English",
pages = "279--85",
journal = "J NEURAL TRANSM-SUPP",
issn = "0303-6995",
publisher = "Springer Wien",
number = "73",

}

RIS

TY - JOUR

T1 - Neurogenesis in substantia nigra of parkinsonian brains?

AU - Arias-Carrión, Oscar

AU - Yamada, Elizabeth

AU - Freundlieb, Nils

AU - Djufri, Miriam

AU - Maurer, Lukas

AU - Hermanns, Guido

AU - Ipach, Bastian

AU - Chiu, Wei-Hua

AU - Steiner, Corinna

AU - Oertel, Wolfgang H

AU - Höglinger, Günter U

PY - 2009/1/1

Y1 - 2009/1/1

N2 - The clinical motor dysfunction in Parkinson's disease is primarily the consequence of a progressive degeneration of dopaminergic neurons in the substantia nigra of the nigrostriatal pathway. The degeneration of this tract provokes a depletion of dopamine in the striatum, where it is required as a permissive factor for normal motor function. Despite intense investigations, no effective therapy is available to prevent the onset or to halt the progression of the neuronal cell loss. Therefore, recent years have seen research into the mechanisms of endogenous repair processes occurring in the adult brain, particularly in the substantia nigra. Neurogenesis occurs in the adult brain in a constitutive manner under physiological circumstances within two regions: the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. In contrast to these two so-called neurogenic areas, the remainder of the brain is considered to be primarily nonneurogenic in nature, implying that no new neurons are produced there under normal conditions. The occurrence of adult neurogenesis in the substantia nigra under the pathological conditions of Parkinson's disease, however, remains controversial. Here, we review the published evidence of whether adult neurogenesis exists or not within the substantia nigra, where dopaminergic neurons are lost in Parkinson's disease.

AB - The clinical motor dysfunction in Parkinson's disease is primarily the consequence of a progressive degeneration of dopaminergic neurons in the substantia nigra of the nigrostriatal pathway. The degeneration of this tract provokes a depletion of dopamine in the striatum, where it is required as a permissive factor for normal motor function. Despite intense investigations, no effective therapy is available to prevent the onset or to halt the progression of the neuronal cell loss. Therefore, recent years have seen research into the mechanisms of endogenous repair processes occurring in the adult brain, particularly in the substantia nigra. Neurogenesis occurs in the adult brain in a constitutive manner under physiological circumstances within two regions: the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. In contrast to these two so-called neurogenic areas, the remainder of the brain is considered to be primarily nonneurogenic in nature, implying that no new neurons are produced there under normal conditions. The occurrence of adult neurogenesis in the substantia nigra under the pathological conditions of Parkinson's disease, however, remains controversial. Here, we review the published evidence of whether adult neurogenesis exists or not within the substantia nigra, where dopaminergic neurons are lost in Parkinson's disease.

KW - Animals

KW - Humans

KW - Models, Biological

KW - Neurogenesis

KW - Neurons

KW - Parkinson Disease

KW - Substantia Nigra

M3 - SCORING: Journal article

C2 - 20411786

SP - 279

EP - 285

JO - J NEURAL TRANSM-SUPP

JF - J NEURAL TRANSM-SUPP

SN - 0303-6995

IS - 73

ER -