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Neurofilament light chain as an early and sensitive predictor of long-term neurological outcome in patients after cardiac arrest

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Neurofilament light chain as an early and sensitive predictor of long-term neurological outcome in patients after cardiac arrest. / Rana, Obaida R; Schröder, Jörg W; Baukloh, Julia K; Saygili, Esra; Mischke, Karl; Schiefer, Johannes; Weis, Joachim; Marx, Nikolaus; Rassaf, Tienush; Kelm, Malte; Shin, Dong-In; Meyer, Christian; Saygili, Erol.

In: INT J CARDIOL, Vol. 168, No. 2, 31.12.2012, p. 1322-1327.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rana, OR, Schröder, JW, Baukloh, JK, Saygili, E, Mischke, K, Schiefer, J, Weis, J, Marx, N, Rassaf, T, Kelm, M, Shin, D-I, Meyer, C & Saygili, E 2012, 'Neurofilament light chain as an early and sensitive predictor of long-term neurological outcome in patients after cardiac arrest', INT J CARDIOL, vol. 168, no. 2, pp. 1322-1327. https://doi.org/10.1016/j.ijcard.2012.12.016

APA

Rana, O. R., Schröder, J. W., Baukloh, J. K., Saygili, E., Mischke, K., Schiefer, J., Weis, J., Marx, N., Rassaf, T., Kelm, M., Shin, D-I., Meyer, C., & Saygili, E. (2012). Neurofilament light chain as an early and sensitive predictor of long-term neurological outcome in patients after cardiac arrest. INT J CARDIOL, 168(2), 1322-1327. https://doi.org/10.1016/j.ijcard.2012.12.016

Vancouver

Rana OR, Schröder JW, Baukloh JK, Saygili E, Mischke K, Schiefer J et al. Neurofilament light chain as an early and sensitive predictor of long-term neurological outcome in patients after cardiac arrest. INT J CARDIOL. 2012 Dec 31;168(2):1322-1327. https://doi.org/10.1016/j.ijcard.2012.12.016

Bibtex

@article{3f03768620c3414fa76c726e176f31d7,
title = "Neurofilament light chain as an early and sensitive predictor of long-term neurological outcome in patients after cardiac arrest",
abstract = "BACKGROUND: Neurofilament light chain (NF-L) is the major intermediate filament specifically expressed in neurons and their axons. No data are available concerning serum levels of NF-L after global cerebral ischemia due to cardiac arrest. To find a specific neuronal marker of long-term neurological outcome, we examined serum levels of NF-L in patients after cardiac arrest.METHODS: A prospective observational cohort study was conducted. Blood samples for the measurement of NF-L were analyzed from 85 patients within 2h after admission, as well as on 2nd, 3rd, 5th, and 7th day. Neurological outcome was assessed 6 months after cardiac arrest by employing the Modified Glasgow Outcome Score (MGOS).RESULTS: The serum course of NF-L in patients with poor neurological outcome (MGOS 1+2) was significantly augmented compared to patients with good neurological outcome (MGOS 3+4+5) (on admission (pg/ml): good: 125 ± 11.7 vs. poor: 884.4 ± 86.2 pg/ml; 3rd day: good: 153.1 ± 13.2 vs. poor: 854.4 ± 119.1; 7th day: good: 112.5 ± 10.4 vs. poor: 1011.8 ± 100.8; P<0.001). Intermediate NF-L serum values were found in patients with MGOS 0, which represents a mixture of patients who died with and without certified brain damage (on admission (pg/dl): 433.7 ± 49.8; 3rd day: 598.3 ± 86.6; 7th day: 474 ± 77.4). A prediction power of 0.93 (c-statistic, 95%-CI 0.87-0.99) on 1st, 0.85 (0.81-0.95) on 2nd, 0.92 (0.85-0.99) on 3rd, 0.97 (0.92-1) on 5th and 0.99 (0.98-1) on 7th day was achieved for NF-L predicting poor neurological outcome.CONCLUSIONS: The present data suggest that within 7 days after cardiac arrest serum NF-L is a valuable marker of long-term neurological outcome.",
keywords = "Aged, Aged, 80 and over, Biomarkers, Cohort Studies, Early Diagnosis, Female, Heart Arrest, Humans, Male, Middle Aged, Nervous System Diseases, Neurofilament Proteins, Predictive Value of Tests, Prospective Studies, Time Factors, Treatment Outcome, Journal Article, Observational Study",
author = "Rana, {Obaida R} and Schr{\"o}der, {J{\"o}rg W} and Baukloh, {Julia K} and Esra Saygili and Karl Mischke and Johannes Schiefer and Joachim Weis and Nikolaus Marx and Tienush Rassaf and Malte Kelm and Dong-In Shin and Christian Meyer and Erol Saygili",
note = "Copyright {\textcopyright} 2012 Elsevier Ireland Ltd. All rights reserved.",
year = "2012",
month = dec,
day = "31",
doi = "10.1016/j.ijcard.2012.12.016",
language = "English",
volume = "168",
pages = "1322--1327",
journal = "INT J CARDIOL",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Neurofilament light chain as an early and sensitive predictor of long-term neurological outcome in patients after cardiac arrest

AU - Rana, Obaida R

AU - Schröder, Jörg W

AU - Baukloh, Julia K

AU - Saygili, Esra

AU - Mischke, Karl

AU - Schiefer, Johannes

AU - Weis, Joachim

AU - Marx, Nikolaus

AU - Rassaf, Tienush

AU - Kelm, Malte

AU - Shin, Dong-In

AU - Meyer, Christian

AU - Saygili, Erol

N1 - Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

PY - 2012/12/31

Y1 - 2012/12/31

N2 - BACKGROUND: Neurofilament light chain (NF-L) is the major intermediate filament specifically expressed in neurons and their axons. No data are available concerning serum levels of NF-L after global cerebral ischemia due to cardiac arrest. To find a specific neuronal marker of long-term neurological outcome, we examined serum levels of NF-L in patients after cardiac arrest.METHODS: A prospective observational cohort study was conducted. Blood samples for the measurement of NF-L were analyzed from 85 patients within 2h after admission, as well as on 2nd, 3rd, 5th, and 7th day. Neurological outcome was assessed 6 months after cardiac arrest by employing the Modified Glasgow Outcome Score (MGOS).RESULTS: The serum course of NF-L in patients with poor neurological outcome (MGOS 1+2) was significantly augmented compared to patients with good neurological outcome (MGOS 3+4+5) (on admission (pg/ml): good: 125 ± 11.7 vs. poor: 884.4 ± 86.2 pg/ml; 3rd day: good: 153.1 ± 13.2 vs. poor: 854.4 ± 119.1; 7th day: good: 112.5 ± 10.4 vs. poor: 1011.8 ± 100.8; P<0.001). Intermediate NF-L serum values were found in patients with MGOS 0, which represents a mixture of patients who died with and without certified brain damage (on admission (pg/dl): 433.7 ± 49.8; 3rd day: 598.3 ± 86.6; 7th day: 474 ± 77.4). A prediction power of 0.93 (c-statistic, 95%-CI 0.87-0.99) on 1st, 0.85 (0.81-0.95) on 2nd, 0.92 (0.85-0.99) on 3rd, 0.97 (0.92-1) on 5th and 0.99 (0.98-1) on 7th day was achieved for NF-L predicting poor neurological outcome.CONCLUSIONS: The present data suggest that within 7 days after cardiac arrest serum NF-L is a valuable marker of long-term neurological outcome.

AB - BACKGROUND: Neurofilament light chain (NF-L) is the major intermediate filament specifically expressed in neurons and their axons. No data are available concerning serum levels of NF-L after global cerebral ischemia due to cardiac arrest. To find a specific neuronal marker of long-term neurological outcome, we examined serum levels of NF-L in patients after cardiac arrest.METHODS: A prospective observational cohort study was conducted. Blood samples for the measurement of NF-L were analyzed from 85 patients within 2h after admission, as well as on 2nd, 3rd, 5th, and 7th day. Neurological outcome was assessed 6 months after cardiac arrest by employing the Modified Glasgow Outcome Score (MGOS).RESULTS: The serum course of NF-L in patients with poor neurological outcome (MGOS 1+2) was significantly augmented compared to patients with good neurological outcome (MGOS 3+4+5) (on admission (pg/ml): good: 125 ± 11.7 vs. poor: 884.4 ± 86.2 pg/ml; 3rd day: good: 153.1 ± 13.2 vs. poor: 854.4 ± 119.1; 7th day: good: 112.5 ± 10.4 vs. poor: 1011.8 ± 100.8; P<0.001). Intermediate NF-L serum values were found in patients with MGOS 0, which represents a mixture of patients who died with and without certified brain damage (on admission (pg/dl): 433.7 ± 49.8; 3rd day: 598.3 ± 86.6; 7th day: 474 ± 77.4). A prediction power of 0.93 (c-statistic, 95%-CI 0.87-0.99) on 1st, 0.85 (0.81-0.95) on 2nd, 0.92 (0.85-0.99) on 3rd, 0.97 (0.92-1) on 5th and 0.99 (0.98-1) on 7th day was achieved for NF-L predicting poor neurological outcome.CONCLUSIONS: The present data suggest that within 7 days after cardiac arrest serum NF-L is a valuable marker of long-term neurological outcome.

KW - Aged

KW - Aged, 80 and over

KW - Biomarkers

KW - Cohort Studies

KW - Early Diagnosis

KW - Female

KW - Heart Arrest

KW - Humans

KW - Male

KW - Middle Aged

KW - Nervous System Diseases

KW - Neurofilament Proteins

KW - Predictive Value of Tests

KW - Prospective Studies

KW - Time Factors

KW - Treatment Outcome

KW - Journal Article

KW - Observational Study

U2 - 10.1016/j.ijcard.2012.12.016

DO - 10.1016/j.ijcard.2012.12.016

M3 - SCORING: Journal article

C2 - 23287695

VL - 168

SP - 1322

EP - 1327

JO - INT J CARDIOL

JF - INT J CARDIOL

SN - 0167-5273

IS - 2

ER -