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Neurofilament light chain as a blood biomarker to differentiate psychiatric disorders from behavioural variant frontotemporal dementia

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Neurofilament light chain as a blood biomarker to differentiate psychiatric disorders from behavioural variant frontotemporal dementia. / Al Shweiki, Mhd Rami; Steinacker, Petra; Oeckl, Patrick; Hengerer, Bastian; Danek, Adrian; Fassbender, Klaus; Diehl-Schmid, Janine; Jahn, Holger; Anderl-Straub, Sarah; Ludolph, Albert C; Schönfeldt-Lecuona, Carlos; Otto, Markus.

In: J PSYCHIATR RES, Vol. 113, 06.2019, p. 137-140.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Al Shweiki, MR, Steinacker, P, Oeckl, P, Hengerer, B, Danek, A, Fassbender, K, Diehl-Schmid, J, Jahn, H, Anderl-Straub, S, Ludolph, AC, Schönfeldt-Lecuona, C & Otto, M 2019, 'Neurofilament light chain as a blood biomarker to differentiate psychiatric disorders from behavioural variant frontotemporal dementia', J PSYCHIATR RES, vol. 113, pp. 137-140. https://doi.org/10.1016/j.jpsychires.2019.03.019

APA

Al Shweiki, M. R., Steinacker, P., Oeckl, P., Hengerer, B., Danek, A., Fassbender, K., Diehl-Schmid, J., Jahn, H., Anderl-Straub, S., Ludolph, A. C., Schönfeldt-Lecuona, C., & Otto, M. (2019). Neurofilament light chain as a blood biomarker to differentiate psychiatric disorders from behavioural variant frontotemporal dementia. J PSYCHIATR RES, 113, 137-140. https://doi.org/10.1016/j.jpsychires.2019.03.019

Vancouver

Al Shweiki MR, Steinacker P, Oeckl P, Hengerer B, Danek A, Fassbender K et al. Neurofilament light chain as a blood biomarker to differentiate psychiatric disorders from behavioural variant frontotemporal dementia. J PSYCHIATR RES. 2019 Jun;113:137-140. https://doi.org/10.1016/j.jpsychires.2019.03.019

Bibtex

@article{0271cc0b624845cea1bb58fbc586b7a9,
title = "Neurofilament light chain as a blood biomarker to differentiate psychiatric disorders from behavioural variant frontotemporal dementia",
abstract = "The overlapping symptoms of behavioural variant frontotemporal dementia (bvFTD) and primary psychiatric disorders (such as depressive disorder, schizophrenia spectrum, and bipolar disorder) present a challenge for the differential diagnosis of bvFTD in middle and older-aged people. Neurofilaments are cytoskeletal proteins in the neurons, and several studies have reported elevated levels of neurofilament light chain (NfL) in cerebrospinal fluid of neurodegenerative as well as psychiatric disorders. The study aims to determine the utility of serum NfL levels as a biomarker to differentiate between bvFTD and psychiatric disorder. In our study, we investigated the levels of NfL in the serum of schizophrenia (n = 11), depression (n = 28), bipolar (n = 11), bvFTD (n = 20) patients and controls (n = 27) by single molecule array (Simoa) technology. The schizophrenia, depression and bipolar patients did not show significant changes in serum NfL levels in comparison to the control group (p > 0.99). The serum NfL levels were significantly elevated in bvFTD patients in comparison to the control cohort (p < 0.0001), depression (p < 0.0001), schizophrenia (p < 0.0002) and bipolar patients (p < 0.0083). We propose serum NfL as a biomarker to differentiate bvFTD from psychiatric disorders and to rule out neurodegeneration in the course of psychiatric disorders.",
author = "{Al Shweiki}, {Mhd Rami} and Petra Steinacker and Patrick Oeckl and Bastian Hengerer and Adrian Danek and Klaus Fassbender and Janine Diehl-Schmid and Holger Jahn and Sarah Anderl-Straub and Ludolph, {Albert C} and Carlos Sch{\"o}nfeldt-Lecuona and Markus Otto",
note = "Copyright {\textcopyright} 2019 Elsevier Ltd. All rights reserved.",
year = "2019",
month = jun,
doi = "10.1016/j.jpsychires.2019.03.019",
language = "English",
volume = "113",
pages = "137--140",
journal = "J PSYCHIATR RES",
issn = "0022-3956",
publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - Neurofilament light chain as a blood biomarker to differentiate psychiatric disorders from behavioural variant frontotemporal dementia

AU - Al Shweiki, Mhd Rami

AU - Steinacker, Petra

AU - Oeckl, Patrick

AU - Hengerer, Bastian

AU - Danek, Adrian

AU - Fassbender, Klaus

AU - Diehl-Schmid, Janine

AU - Jahn, Holger

AU - Anderl-Straub, Sarah

AU - Ludolph, Albert C

AU - Schönfeldt-Lecuona, Carlos

AU - Otto, Markus

N1 - Copyright © 2019 Elsevier Ltd. All rights reserved.

PY - 2019/6

Y1 - 2019/6

N2 - The overlapping symptoms of behavioural variant frontotemporal dementia (bvFTD) and primary psychiatric disorders (such as depressive disorder, schizophrenia spectrum, and bipolar disorder) present a challenge for the differential diagnosis of bvFTD in middle and older-aged people. Neurofilaments are cytoskeletal proteins in the neurons, and several studies have reported elevated levels of neurofilament light chain (NfL) in cerebrospinal fluid of neurodegenerative as well as psychiatric disorders. The study aims to determine the utility of serum NfL levels as a biomarker to differentiate between bvFTD and psychiatric disorder. In our study, we investigated the levels of NfL in the serum of schizophrenia (n = 11), depression (n = 28), bipolar (n = 11), bvFTD (n = 20) patients and controls (n = 27) by single molecule array (Simoa) technology. The schizophrenia, depression and bipolar patients did not show significant changes in serum NfL levels in comparison to the control group (p > 0.99). The serum NfL levels were significantly elevated in bvFTD patients in comparison to the control cohort (p < 0.0001), depression (p < 0.0001), schizophrenia (p < 0.0002) and bipolar patients (p < 0.0083). We propose serum NfL as a biomarker to differentiate bvFTD from psychiatric disorders and to rule out neurodegeneration in the course of psychiatric disorders.

AB - The overlapping symptoms of behavioural variant frontotemporal dementia (bvFTD) and primary psychiatric disorders (such as depressive disorder, schizophrenia spectrum, and bipolar disorder) present a challenge for the differential diagnosis of bvFTD in middle and older-aged people. Neurofilaments are cytoskeletal proteins in the neurons, and several studies have reported elevated levels of neurofilament light chain (NfL) in cerebrospinal fluid of neurodegenerative as well as psychiatric disorders. The study aims to determine the utility of serum NfL levels as a biomarker to differentiate between bvFTD and psychiatric disorder. In our study, we investigated the levels of NfL in the serum of schizophrenia (n = 11), depression (n = 28), bipolar (n = 11), bvFTD (n = 20) patients and controls (n = 27) by single molecule array (Simoa) technology. The schizophrenia, depression and bipolar patients did not show significant changes in serum NfL levels in comparison to the control group (p > 0.99). The serum NfL levels were significantly elevated in bvFTD patients in comparison to the control cohort (p < 0.0001), depression (p < 0.0001), schizophrenia (p < 0.0002) and bipolar patients (p < 0.0083). We propose serum NfL as a biomarker to differentiate bvFTD from psychiatric disorders and to rule out neurodegeneration in the course of psychiatric disorders.

U2 - 10.1016/j.jpsychires.2019.03.019

DO - 10.1016/j.jpsychires.2019.03.019

M3 - SCORING: Journal article

C2 - 30953863

VL - 113

SP - 137

EP - 140

JO - J PSYCHIATR RES

JF - J PSYCHIATR RES

SN - 0022-3956

ER -