Neurocognitive Mechanisms of Social Inferences in Typical and Autistic Adolescents

TY - JOUR

T1 - Neurocognitive Mechanisms of Social Inferences in Typical and Autistic Adolescents

AU - Rosenblau, Gabriela

AU - Korn, Christoph W

AU - Dutton, Abigail

AU - Lee, Daeyeol

AU - Pelphrey, Kevin A

N1 - Copyright © 2020 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

PY - 2021/8

Y1 - 2021/8

N2 - BACKGROUND: Many of our efforts in social interactions are dedicated to learning about others. Adolescents with autism have core deficits in social learning, but a mechanistic understanding of these deficits and how they relate to neural development is lacking. The present study aimed to specify how adolescents with and without autism represent and acquire social knowledge and how these processes are implemented in neural activity.METHODS: Typically developing adolescents (n = 26) and adolescents with autism spectrum disorder (ASD) (n = 20) rated in the magnetic resonance scanner how much 3 peers liked a variety of items and received trial-by-trial feedback about the peers' actual preference ratings. In a separate study, we established the preferences of a new sample of adolescents (N = 99), used to examine population preference structures. Using computational models, we tested whether participants in the magnetic resonance study relied on preference structures during learning and how model predictions were implemented in brain activity.RESULTS: Typically developing adolescents relied on average population preferences and prediction error updating. Importantly, prediction error updating was scaled by the similarity between items. In contrast, preferences of adolescents with ASD were best described by a No-Learning model that relied only on the participant's own preferences for each item. Model predictions were encoded in neural activity. Typically developing adolescents encoded prediction errors in the putamen, and adolescents with ASD showed greater encoding of own preferences in the angular gyrus.CONCLUSIONS: We specified how adolescents represent and update social knowledge during learning. Our findings indicate that adolescents with ASD rely only on their own preferences when making social inferences.

AB - BACKGROUND: Many of our efforts in social interactions are dedicated to learning about others. Adolescents with autism have core deficits in social learning, but a mechanistic understanding of these deficits and how they relate to neural development is lacking. The present study aimed to specify how adolescents with and without autism represent and acquire social knowledge and how these processes are implemented in neural activity.METHODS: Typically developing adolescents (n = 26) and adolescents with autism spectrum disorder (ASD) (n = 20) rated in the magnetic resonance scanner how much 3 peers liked a variety of items and received trial-by-trial feedback about the peers' actual preference ratings. In a separate study, we established the preferences of a new sample of adolescents (N = 99), used to examine population preference structures. Using computational models, we tested whether participants in the magnetic resonance study relied on preference structures during learning and how model predictions were implemented in brain activity.RESULTS: Typically developing adolescents relied on average population preferences and prediction error updating. Importantly, prediction error updating was scaled by the similarity between items. In contrast, preferences of adolescents with ASD were best described by a No-Learning model that relied only on the participant's own preferences for each item. Model predictions were encoded in neural activity. Typically developing adolescents encoded prediction errors in the putamen, and adolescents with ASD showed greater encoding of own preferences in the angular gyrus.CONCLUSIONS: We specified how adolescents represent and update social knowledge during learning. Our findings indicate that adolescents with ASD rely only on their own preferences when making social inferences.

U2 - 10.1016/j.bpsc.2020.07.002

DO - 10.1016/j.bpsc.2020.07.002

M3 - SCORING: Journal article

C2 - 32952091

VL - 6

SP - 782

EP - 791

JO - BIOL PSYCHIAT-COGN N

JF - BIOL PSYCHIAT-COGN N

SN - 2451-9022

IS - 8

ER -