Neural response to emotional stimuli during experimental human endotoxemia.
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Neural response to emotional stimuli during experimental human endotoxemia. / Kullmann, Jennifer S; Grigoleit, Jan-Sebastian; Lichte, Philipp; Kobbe, Philipp; Rosenberger, Christina; Banner, Christina; Wolf, Oliver T; Engler, Harald; Oberbeck, Reiner; Elsenbruch, Sigrid; Bingel, Ulrike; Forsting, Michael; Gizewski, Elke R; Schedlowski, Manfred.
In: HUM BRAIN MAPP, Vol. 34, No. 9, 9, 2013, p. 2217-2227.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Neural response to emotional stimuli during experimental human endotoxemia.
AU - Kullmann, Jennifer S
AU - Grigoleit, Jan-Sebastian
AU - Lichte, Philipp
AU - Kobbe, Philipp
AU - Rosenberger, Christina
AU - Banner, Christina
AU - Wolf, Oliver T
AU - Engler, Harald
AU - Oberbeck, Reiner
AU - Elsenbruch, Sigrid
AU - Bingel, Ulrike
AU - Forsting, Michael
AU - Gizewski, Elke R
AU - Schedlowski, Manfred
PY - 2013
Y1 - 2013
N2 - Increases in peripheral cytokines during acute inflammation may affect various neuropsychological functions. The aim of this functional magnetic resonance imaging (fMRI) study was to investigate the effects of acute endotoxemia on mood and the neural response to emotionally aversive visual stimuli in healthy human subjects. In a double-blind, randomized crossover study, 18 healthy males received a bolus injection of bacterial lipopolysaccharide (LPS; 0.4 ng/kg) or saline. Plasma levels of pro- and anti-inflammatory cytokines and cortisol as well as mood ratings were analyzed together with the blood-oxygen-level dependent (BOLD) response during the presentation of aversive versus neutral pictures. Endotoxin administration induced pronounced transient increases in plasma levels of TNF-?, IL-1ra, IL-6, IL-10, and cortisol. Positive mood was decreased and state anxiety increased. In addition, activation of right inferior orbitofrontal cortex (OFC) in response to emotional visual stimuli was significantly increased in the LPS condition. Increased prefrontal activation during the presentation of emotional material may reflect enhanced cognitive regulation of emotions as an adaptive response during an acute inflammation. These findings may have implications for the putative role of inflammatory processes in the pathophysiology of depression.
AB - Increases in peripheral cytokines during acute inflammation may affect various neuropsychological functions. The aim of this functional magnetic resonance imaging (fMRI) study was to investigate the effects of acute endotoxemia on mood and the neural response to emotionally aversive visual stimuli in healthy human subjects. In a double-blind, randomized crossover study, 18 healthy males received a bolus injection of bacterial lipopolysaccharide (LPS; 0.4 ng/kg) or saline. Plasma levels of pro- and anti-inflammatory cytokines and cortisol as well as mood ratings were analyzed together with the blood-oxygen-level dependent (BOLD) response during the presentation of aversive versus neutral pictures. Endotoxin administration induced pronounced transient increases in plasma levels of TNF-?, IL-1ra, IL-6, IL-10, and cortisol. Positive mood was decreased and state anxiety increased. In addition, activation of right inferior orbitofrontal cortex (OFC) in response to emotional visual stimuli was significantly increased in the LPS condition. Increased prefrontal activation during the presentation of emotional material may reflect enhanced cognitive regulation of emotions as an adaptive response during an acute inflammation. These findings may have implications for the putative role of inflammatory processes in the pathophysiology of depression.
M3 - SCORING: Journal article
VL - 34
SP - 2217
EP - 2227
JO - HUM BRAIN MAPP
JF - HUM BRAIN MAPP
SN - 1065-9471
IS - 9
M1 - 9
ER -
