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Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse

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Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse. / Jia, Tianye; Xie, Chao; Banaschewski, Tobias; Barker, Gareth J; Bokde, Arun L W; Büchel, Christian; Quinlan, Erin Burke; Desrivières, Sylvane; Flor, Herta; Grigis, Antoine; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Poustka, Luise; Fröhner, Juliane H; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Schumann, Gunter; Robbins, Trevor W; Feng, Jianfeng; IMAGEN Consortium.

In: SCI ADV, Vol. 7, No. 6, 02.2021.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Jia, T, Xie, C, Banaschewski, T, Barker, GJ, Bokde, ALW, Büchel, C, Quinlan, EB, Desrivières, S, Flor, H, Grigis, A, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Martinot, J-L, Martinot, M-LP, Nees, F, Orfanos, DP, Poustka, L, Fröhner, JH, Smolka, MN, Walter, H, Whelan, R, Schumann, G, Robbins, TW, Feng, J & IMAGEN Consortium 2021, 'Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse', SCI ADV, vol. 7, no. 6. https://doi.org/10.1126/sciadv.abd4074

APA

Jia, T., Xie, C., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Büchel, C., Quinlan, E. B., Desrivières, S., Flor, H., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J-L., Martinot, M-L. P., Nees, F., Orfanos, D. P., Poustka, L., ... IMAGEN Consortium (2021). Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse. SCI ADV, 7(6). https://doi.org/10.1126/sciadv.abd4074

Vancouver

Jia T, Xie C, Banaschewski T, Barker GJ, Bokde ALW, Büchel C et al. Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse. SCI ADV. 2021 Feb;7(6). https://doi.org/10.1126/sciadv.abd4074

Bibtex

@article{62d8d16374084f27b2b1e61931d0d1c6,
title = "Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse",
abstract = "Prompted by recent evidence of neural circuitry in rodent models, functional magnetic resonance imaging and functional connectivity analyses were conducted for a large adolescent population at two ages, together with alcohol abuse measures, to characterize a neural network that may underlie the onset of alcoholism. A network centered on the medial orbitofrontal cortex (mOFC), as well as including the dorsal periaqueductal gray (dPAG), central nucleus of the amygdala, and nucleus accumbens, was identified, consistent with the rodent models, with evidence of both inhibitory and excitatory coregulation by the mOFC over the dPAG. Furthermore, significant relationships were detected between raised baseline excitatory coregulation in this network and impulsivity measures, supporting a role for negative urgency in alcohol dependence.",
author = "Tianye Jia and Chao Xie and Tobias Banaschewski and Barker, {Gareth J} and Bokde, {Arun L W} and Christian B{\"u}chel and Quinlan, {Erin Burke} and Sylvane Desrivi{\`e}res and Herta Flor and Antoine Grigis and Hugh Garavan and Penny Gowland and Andreas Heinz and Bernd Ittermann and Jean-Luc Martinot and Martinot, {Marie-Laure Paill{\`e}re} and Frauke Nees and Orfanos, {Dimitri Papadopoulos} and Luise Poustka and Fr{\"o}hner, {Juliane H} and Smolka, {Michael N} and Henrik Walter and Robert Whelan and Gunter Schumann and Robbins, {Trevor W} and Jianfeng Feng and {IMAGEN Consortium}",
note = "Copyright {\textcopyright} 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).",
year = "2021",
month = feb,
doi = "10.1126/sciadv.abd4074",
language = "English",
volume = "7",
journal = "SCI ADV",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "6",

}

RIS

TY - JOUR

T1 - Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse

AU - Jia, Tianye

AU - Xie, Chao

AU - Banaschewski, Tobias

AU - Barker, Gareth J

AU - Bokde, Arun L W

AU - Büchel, Christian

AU - Quinlan, Erin Burke

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Grigis, Antoine

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Martinot, Jean-Luc

AU - Martinot, Marie-Laure Paillère

AU - Nees, Frauke

AU - Orfanos, Dimitri Papadopoulos

AU - Poustka, Luise

AU - Fröhner, Juliane H

AU - Smolka, Michael N

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

AU - Robbins, Trevor W

AU - Feng, Jianfeng

AU - IMAGEN Consortium

N1 - Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

PY - 2021/2

Y1 - 2021/2

N2 - Prompted by recent evidence of neural circuitry in rodent models, functional magnetic resonance imaging and functional connectivity analyses were conducted for a large adolescent population at two ages, together with alcohol abuse measures, to characterize a neural network that may underlie the onset of alcoholism. A network centered on the medial orbitofrontal cortex (mOFC), as well as including the dorsal periaqueductal gray (dPAG), central nucleus of the amygdala, and nucleus accumbens, was identified, consistent with the rodent models, with evidence of both inhibitory and excitatory coregulation by the mOFC over the dPAG. Furthermore, significant relationships were detected between raised baseline excitatory coregulation in this network and impulsivity measures, supporting a role for negative urgency in alcohol dependence.

AB - Prompted by recent evidence of neural circuitry in rodent models, functional magnetic resonance imaging and functional connectivity analyses were conducted for a large adolescent population at two ages, together with alcohol abuse measures, to characterize a neural network that may underlie the onset of alcoholism. A network centered on the medial orbitofrontal cortex (mOFC), as well as including the dorsal periaqueductal gray (dPAG), central nucleus of the amygdala, and nucleus accumbens, was identified, consistent with the rodent models, with evidence of both inhibitory and excitatory coregulation by the mOFC over the dPAG. Furthermore, significant relationships were detected between raised baseline excitatory coregulation in this network and impulsivity measures, supporting a role for negative urgency in alcohol dependence.

U2 - 10.1126/sciadv.abd4074

DO - 10.1126/sciadv.abd4074

M3 - SCORING: Journal article

C2 - 33536210

VL - 7

JO - SCI ADV

JF - SCI ADV

SN - 2375-2548

IS - 6

ER -