Neural mechanisms of attention-deficit/hyperactivity disorder symptoms are stratified by MAOA genotype

Charlotte Nymberg; Tianye Jia; Steven Lubbe; Barbara Ruggeri; Sylvane Desrivieres; Gareth Barker; Christian Büchel; Mira Fauth-Buehler; Anna Cattrell; Patricia Conrod; Herta Flor; Jürgen Gallinat; Hugh Garavan; Andreas Heinz; Bernd Ittermann; Claire Lawrence; Karl Mann; Frauke Nees; Angelica Salatino-Oliveira; Marie-Laure Paillère Martinot; Tomas Paus; Marcella Rietschel; Trevor Robbins; Michael Smolka; Tobias Banaschewski; Katya Rubia; Eva Loth; Gunter Schumann; IMAGEN Consortium

doi:10.1016/j.biopsych.2013.03.027

Neural mechanisms of attention-deficit/hyperactivity disorder symptoms are stratified by MAOA genotype

Standard

Neural mechanisms of attention-deficit/hyperactivity disorder symptoms are stratified by MAOA genotype. / Nymberg, Charlotte; Jia, Tianye; Lubbe, Steven; Ruggeri, Barbara; Desrivieres, Sylvane; Barker, Gareth; Büchel, Christian; Fauth-Buehler, Mira; Cattrell, Anna; Conrod, Patricia; Flor, Herta; Gallinat, Jürgen; Garavan, Hugh; Heinz, Andreas; Ittermann, Bernd; Lawrence, Claire; Mann, Karl; Nees, Frauke; Salatino-Oliveira, Angelica; Paillère Martinot, Marie-Laure; Paus, Tomas; Rietschel, Marcella; Robbins, Trevor; Smolka, Michael; Banaschewski, Tobias; Rubia, Katya; Loth, Eva; Schumann, Gunter; IMAGEN Consortium.

In: BIOL PSYCHIAT, Vol. 74, No. 8, 15.10.2013, p. 607-14.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Nymberg, C, Jia, T, Lubbe, S, Ruggeri, B, Desrivieres, S, Barker, G, Büchel, C, Fauth-Buehler, M, Cattrell, A, Conrod, P, Flor, H, Gallinat, J, Garavan, H, Heinz, A, Ittermann, B, Lawrence, C, Mann, K, Nees, F, Salatino-Oliveira, A, Paillère Martinot, M-L, Paus, T, Rietschel, M, Robbins, T, Smolka, M, Banaschewski, T, Rubia, K, Loth, E, Schumann, G & IMAGEN Consortium 2013, 'Neural mechanisms of attention-deficit/hyperactivity disorder symptoms are stratified by MAOA genotype', BIOL PSYCHIAT, vol. 74, no. 8, pp. 607-14. https://doi.org/10.1016/j.biopsych.2013.03.027

APA

Nymberg, C., Jia, T., Lubbe, S., Ruggeri, B., Desrivieres, S., Barker, G., Büchel, C., Fauth-Buehler, M., Cattrell, A., Conrod, P., Flor, H., Gallinat, J., Garavan, H., Heinz, A., Ittermann, B., Lawrence, C., Mann, K., Nees, F., Salatino-Oliveira, A., ... IMAGEN Consortium (2013). Neural mechanisms of attention-deficit/hyperactivity disorder symptoms are stratified by MAOA genotype. BIOL PSYCHIAT, 74(8), 607-14. https://doi.org/10.1016/j.biopsych.2013.03.027

Vancouver

Nymberg C, Jia T, Lubbe S, Ruggeri B, Desrivieres S, Barker G et al. Neural mechanisms of attention-deficit/hyperactivity disorder symptoms are stratified by MAOA genotype. BIOL PSYCHIAT. 2013 Oct 15;74(8):607-14. https://doi.org/10.1016/j.biopsych.2013.03.027

Bibtex

@article{6de555772917464c81a5f18b1c444357,

title = "Neural mechanisms of attention-deficit/hyperactivity disorder symptoms are stratified by MAOA genotype",

abstract = "BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is characterized by deficits in reward sensitivity and response inhibition. The relative contribution of these frontostriatal mechanisms to ADHD symptoms and their genetic determinants is largely unexplored.METHODS: Using functional magnetic resonance imaging and genetic analysis of the monoamine oxidase A (MAOA) gene, we investigated how striatal and inferior frontal activation patterns contribute to ADHD symptoms depending on MAOA genotype in a sample of adolescent boys (n = 190).RESULTS: We demonstrate an association of ADHD symptoms with distinct blood oxygen level-dependent (BOLD) responses depending on MAOA genotype. In A hemizygotes of the expression single nucleotide polymorphism rs12843268, which express lower levels of MAOA, ADHD symptoms are associated with lower ventral striatal BOLD response during the monetary incentive delay task and lower inferior frontal gyrus BOLD response during the stop signal task. In G hemizygotes, ADHD symptoms are associated with increased inferior frontal gyrus BOLD response during the stop signal task in the presence of increased ventral striatal BOLD response during the monetary incentive delay task.CONCLUSIONS: Depending on MAOA genotype, ADHD symptoms in adolescent boys are associated with either reward deficiency or insufficient response inhibition. Apart from its mechanistic interest, our finding may aid in developing pharmacogenetic markers for ADHD.",

author = "Charlotte Nymberg and Tianye Jia and Steven Lubbe and Barbara Ruggeri and Sylvane Desrivieres and Gareth Barker and Christian B{\"u}chel and Mira Fauth-Buehler and Anna Cattrell and Patricia Conrod and Herta Flor and J{\"u}rgen Gallinat and Hugh Garavan and Andreas Heinz and Bernd Ittermann and Claire Lawrence and Karl Mann and Frauke Nees and Angelica Salatino-Oliveira and {Paill{\`e}re Martinot}, Marie-Laure and Tomas Paus and Marcella Rietschel and Trevor Robbins and Michael Smolka and Tobias Banaschewski and Katya Rubia and Eva Loth and Gunter Schumann and {IMAGEN Consortium} and J{\"u}rgen Finsterbusch",

year = "2013",

month = oct,

day = "15",

doi = "10.1016/j.biopsych.2013.03.027",

language = "English",

volume = "74",

pages = "607--14",

journal = "BIOL PSYCHIAT",

issn = "0006-3223",

publisher = "Elsevier USA",

number = "8",

}

RIS

TY - JOUR

T1 - Neural mechanisms of attention-deficit/hyperactivity disorder symptoms are stratified by MAOA genotype

AU - Nymberg, Charlotte

AU - Jia, Tianye

AU - Lubbe, Steven

AU - Ruggeri, Barbara

AU - Desrivieres, Sylvane

AU - Barker, Gareth

AU - Büchel, Christian

AU - Fauth-Buehler, Mira

AU - Cattrell, Anna

AU - Conrod, Patricia

AU - Flor, Herta

AU - Gallinat, Jürgen

AU - Garavan, Hugh

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Lawrence, Claire

AU - Mann, Karl

AU - Nees, Frauke

AU - Salatino-Oliveira, Angelica

AU - Paillère Martinot, Marie-Laure

AU - Paus, Tomas

AU - Rietschel, Marcella

AU - Robbins, Trevor

AU - Smolka, Michael

AU - Banaschewski, Tobias

AU - Rubia, Katya

AU - Loth, Eva

AU - Schumann, Gunter

AU - IMAGEN Consortium

AU - Finsterbusch, Jürgen

PY - 2013/10/15

Y1 - 2013/10/15

N2 - BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is characterized by deficits in reward sensitivity and response inhibition. The relative contribution of these frontostriatal mechanisms to ADHD symptoms and their genetic determinants is largely unexplored.METHODS: Using functional magnetic resonance imaging and genetic analysis of the monoamine oxidase A (MAOA) gene, we investigated how striatal and inferior frontal activation patterns contribute to ADHD symptoms depending on MAOA genotype in a sample of adolescent boys (n = 190).RESULTS: We demonstrate an association of ADHD symptoms with distinct blood oxygen level-dependent (BOLD) responses depending on MAOA genotype. In A hemizygotes of the expression single nucleotide polymorphism rs12843268, which express lower levels of MAOA, ADHD symptoms are associated with lower ventral striatal BOLD response during the monetary incentive delay task and lower inferior frontal gyrus BOLD response during the stop signal task. In G hemizygotes, ADHD symptoms are associated with increased inferior frontal gyrus BOLD response during the stop signal task in the presence of increased ventral striatal BOLD response during the monetary incentive delay task.CONCLUSIONS: Depending on MAOA genotype, ADHD symptoms in adolescent boys are associated with either reward deficiency or insufficient response inhibition. Apart from its mechanistic interest, our finding may aid in developing pharmacogenetic markers for ADHD.

AB - BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is characterized by deficits in reward sensitivity and response inhibition. The relative contribution of these frontostriatal mechanisms to ADHD symptoms and their genetic determinants is largely unexplored.METHODS: Using functional magnetic resonance imaging and genetic analysis of the monoamine oxidase A (MAOA) gene, we investigated how striatal and inferior frontal activation patterns contribute to ADHD symptoms depending on MAOA genotype in a sample of adolescent boys (n = 190).RESULTS: We demonstrate an association of ADHD symptoms with distinct blood oxygen level-dependent (BOLD) responses depending on MAOA genotype. In A hemizygotes of the expression single nucleotide polymorphism rs12843268, which express lower levels of MAOA, ADHD symptoms are associated with lower ventral striatal BOLD response during the monetary incentive delay task and lower inferior frontal gyrus BOLD response during the stop signal task. In G hemizygotes, ADHD symptoms are associated with increased inferior frontal gyrus BOLD response during the stop signal task in the presence of increased ventral striatal BOLD response during the monetary incentive delay task.CONCLUSIONS: Depending on MAOA genotype, ADHD symptoms in adolescent boys are associated with either reward deficiency or insufficient response inhibition. Apart from its mechanistic interest, our finding may aid in developing pharmacogenetic markers for ADHD.

U2 - 10.1016/j.biopsych.2013.03.027

DO - 10.1016/j.biopsych.2013.03.027

M3 - SCORING: Journal article

C2 - 23746540

VL - 74

SP - 607

EP - 614

JO - BIOL PSYCHIAT

JF - BIOL PSYCHIAT

SN - 0006-3223

IS - 8

ER -