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Neural driven angiogenesis by overexpression of nerve growth factor.

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Neural driven angiogenesis by overexpression of nerve growth factor. / Hansen-Algenstaedt, N; Algenstaedt, P; Schäfer, Christian; Hamann, A; Wolfram, L; Cingöz, G; Kilic, Nerbil; Schwarzloh, B; Schröder, Malte; Joscheck, C; Wiesner, L; Rüther, Wolfgang; Ergün, S.

In: HISTOCHEM CELL BIOL, Vol. 125, No. 6, 6, 2006, p. 637-649.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hansen-Algenstaedt, N, Algenstaedt, P, Schäfer, C, Hamann, A, Wolfram, L, Cingöz, G, Kilic, N, Schwarzloh, B, Schröder, M, Joscheck, C, Wiesner, L, Rüther, W & Ergün, S 2006, 'Neural driven angiogenesis by overexpression of nerve growth factor.', HISTOCHEM CELL BIOL, vol. 125, no. 6, 6, pp. 637-649. <http://www.ncbi.nlm.nih.gov/pubmed/16315017?dopt=Citation>

APA

Hansen-Algenstaedt, N., Algenstaedt, P., Schäfer, C., Hamann, A., Wolfram, L., Cingöz, G., Kilic, N., Schwarzloh, B., Schröder, M., Joscheck, C., Wiesner, L., Rüther, W., & Ergün, S. (2006). Neural driven angiogenesis by overexpression of nerve growth factor. HISTOCHEM CELL BIOL, 125(6), 637-649. [6]. http://www.ncbi.nlm.nih.gov/pubmed/16315017?dopt=Citation

Vancouver

Hansen-Algenstaedt N, Algenstaedt P, Schäfer C, Hamann A, Wolfram L, Cingöz G et al. Neural driven angiogenesis by overexpression of nerve growth factor. HISTOCHEM CELL BIOL. 2006;125(6):637-649. 6.

Bibtex

@article{2903be0581e14588a37dff2ee5dd2266,
title = "Neural driven angiogenesis by overexpression of nerve growth factor.",
abstract = "Mechanisms regulating angiogenesis are crucial in adjusting tissue perfusion on metabolic demands. We demonstrate that overexpression of nerve growth factor (NGF) in brown adipose tissue (BAT) of NGF-transgenic mice elevates both mRNA and protein levels of vascular endothelial growth factor (VEGF) and VEGF-receptors. Increased vascular permeability, leukocyte-endothelial interactions (LEI), and tissue perfusion were measured using intravital microscopy. NGF-stimulation of adipocytes and endothelial cells elevates mRNA expression of VEGF and its receptors, an effect blocked by NGF neutralizing antibodies. These data suggest an activation of angiogenesis as a result of both: stimulation of adipozytes and direct mitogenic effects on endothelial cells. The increased nerve density associated with vessels strengthened our hypothesis that tissue perfusion is regulated by neural control of vessels and that the interaction between the NGF and VEGF systems is the critical driver for the activated angiogenic process. The interaction of VEGF- and NGF-systems gives new insights into neural control of organ vascularization and perfusion.",
author = "N Hansen-Algenstaedt and P Algenstaedt and Christian Sch{\"a}fer and A Hamann and L Wolfram and G Cing{\"o}z and Nerbil Kilic and B Schwarzloh and Malte Schr{\"o}der and C Joscheck and L Wiesner and Wolfgang R{\"u}ther and S Erg{\"u}n",
year = "2006",
language = "Deutsch",
volume = "125",
pages = "637--649",
journal = "HISTOCHEM CELL BIOL",
issn = "0948-6143",
publisher = "Springer",
number = "6",

}

RIS

TY - JOUR

T1 - Neural driven angiogenesis by overexpression of nerve growth factor.

AU - Hansen-Algenstaedt, N

AU - Algenstaedt, P

AU - Schäfer, Christian

AU - Hamann, A

AU - Wolfram, L

AU - Cingöz, G

AU - Kilic, Nerbil

AU - Schwarzloh, B

AU - Schröder, Malte

AU - Joscheck, C

AU - Wiesner, L

AU - Rüther, Wolfgang

AU - Ergün, S

PY - 2006

Y1 - 2006

N2 - Mechanisms regulating angiogenesis are crucial in adjusting tissue perfusion on metabolic demands. We demonstrate that overexpression of nerve growth factor (NGF) in brown adipose tissue (BAT) of NGF-transgenic mice elevates both mRNA and protein levels of vascular endothelial growth factor (VEGF) and VEGF-receptors. Increased vascular permeability, leukocyte-endothelial interactions (LEI), and tissue perfusion were measured using intravital microscopy. NGF-stimulation of adipocytes and endothelial cells elevates mRNA expression of VEGF and its receptors, an effect blocked by NGF neutralizing antibodies. These data suggest an activation of angiogenesis as a result of both: stimulation of adipozytes and direct mitogenic effects on endothelial cells. The increased nerve density associated with vessels strengthened our hypothesis that tissue perfusion is regulated by neural control of vessels and that the interaction between the NGF and VEGF systems is the critical driver for the activated angiogenic process. The interaction of VEGF- and NGF-systems gives new insights into neural control of organ vascularization and perfusion.

AB - Mechanisms regulating angiogenesis are crucial in adjusting tissue perfusion on metabolic demands. We demonstrate that overexpression of nerve growth factor (NGF) in brown adipose tissue (BAT) of NGF-transgenic mice elevates both mRNA and protein levels of vascular endothelial growth factor (VEGF) and VEGF-receptors. Increased vascular permeability, leukocyte-endothelial interactions (LEI), and tissue perfusion were measured using intravital microscopy. NGF-stimulation of adipocytes and endothelial cells elevates mRNA expression of VEGF and its receptors, an effect blocked by NGF neutralizing antibodies. These data suggest an activation of angiogenesis as a result of both: stimulation of adipozytes and direct mitogenic effects on endothelial cells. The increased nerve density associated with vessels strengthened our hypothesis that tissue perfusion is regulated by neural control of vessels and that the interaction between the NGF and VEGF systems is the critical driver for the activated angiogenic process. The interaction of VEGF- and NGF-systems gives new insights into neural control of organ vascularization and perfusion.

M3 - SCORING: Zeitschriftenaufsatz

VL - 125

SP - 637

EP - 649

JO - HISTOCHEM CELL BIOL

JF - HISTOCHEM CELL BIOL

SN - 0948-6143

IS - 6

M1 - 6

ER -