Neural crest origin of mammalian Merkel cells.
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Neural crest origin of mammalian Merkel cells. / Szeder, Viktor; Grim, Milos; Halata, Zdenek; Sieber-Blum, Maya.
In: DEV BIOL, Vol. 253, No. 2, 2, 2003, p. 258-263.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Neural crest origin of mammalian Merkel cells.
AU - Szeder, Viktor
AU - Grim, Milos
AU - Halata, Zdenek
AU - Sieber-Blum, Maya
PY - 2003
Y1 - 2003
N2 - Here, we provide evidence for the neural crest origin of mammalian Merkel cells. Together with nerve terminals, Merkel cells form slowly adapting cutaneous mechanoreceptors that transduce steady indentation in hairy and glabrous skin. We have determined the ontogenetic origin of Merkel cells in Wnt1-cre/R26R compound transgenic mice, in which neural crest cells are marked indelibly. Merkel cells in whiskers and interfollicular locations express the transgene, beta-galactosidase, identifying them as neural crest descendants. We thus conclude that murine Merkel cells originate from the neural crest.
AB - Here, we provide evidence for the neural crest origin of mammalian Merkel cells. Together with nerve terminals, Merkel cells form slowly adapting cutaneous mechanoreceptors that transduce steady indentation in hairy and glabrous skin. We have determined the ontogenetic origin of Merkel cells in Wnt1-cre/R26R compound transgenic mice, in which neural crest cells are marked indelibly. Merkel cells in whiskers and interfollicular locations express the transgene, beta-galactosidase, identifying them as neural crest descendants. We thus conclude that murine Merkel cells originate from the neural crest.
M3 - SCORING: Zeitschriftenaufsatz
VL - 253
SP - 258
EP - 263
JO - DEV BIOL
JF - DEV BIOL
SN - 0012-1606
IS - 2
M1 - 2
ER -