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Neural Correlates of Failed Inhibitory Control as an Early Marker of Disordered Eating in Adolescents

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Neural Correlates of Failed Inhibitory Control as an Early Marker of Disordered Eating in Adolescents. / Bartholdy, Savani; O'Daly, Owen G; Campbell, Iain C; Banaschewski, Tobias; Barker, Gareth; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Quinlan, Erin Burke; Desrivières, Sylvane; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Paillère Martinot, Marie-Laure; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Poustka, Luise; Hohmann, Sarah; Fröhner, Juliane H; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Schumann, Gunter; Schmidt, Ulrike; IMAGEN Consortium.

In: BIOL PSYCHIAT, Vol. 85, No. 11, 01.06.2019, p. 956-965.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bartholdy, S, O'Daly, OG, Campbell, IC, Banaschewski, T, Barker, G, Bokde, ALW, Bromberg, U, Büchel, C, Quinlan, EB, Desrivières, S, Flor, H, Frouin, V, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Martinot, J-L, Paillère Martinot, M-L, Nees, F, Orfanos, DP, Poustka, L, Hohmann, S, Fröhner, JH, Smolka, MN, Walter, H, Whelan, R, Schumann, G, Schmidt, U & IMAGEN Consortium 2019, 'Neural Correlates of Failed Inhibitory Control as an Early Marker of Disordered Eating in Adolescents', BIOL PSYCHIAT, vol. 85, no. 11, pp. 956-965. https://doi.org/10.1016/j.biopsych.2019.01.027

APA

Bartholdy, S., O'Daly, O. G., Campbell, I. C., Banaschewski, T., Barker, G., Bokde, A. L. W., Bromberg, U., Büchel, C., Quinlan, E. B., Desrivières, S., Flor, H., Frouin, V., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J-L., Paillère Martinot, M-L., Nees, F., ... IMAGEN Consortium (2019). Neural Correlates of Failed Inhibitory Control as an Early Marker of Disordered Eating in Adolescents. BIOL PSYCHIAT, 85(11), 956-965. https://doi.org/10.1016/j.biopsych.2019.01.027

Vancouver

Bartholdy S, O'Daly OG, Campbell IC, Banaschewski T, Barker G, Bokde ALW et al. Neural Correlates of Failed Inhibitory Control as an Early Marker of Disordered Eating in Adolescents. BIOL PSYCHIAT. 2019 Jun 1;85(11):956-965. https://doi.org/10.1016/j.biopsych.2019.01.027

Bibtex

@article{1819322d45d5492fa21774a5d9e85eff,
title = "Neural Correlates of Failed Inhibitory Control as an Early Marker of Disordered Eating in Adolescents",
abstract = "BACKGROUND: Binge eating and other forms of disordered eating behavior (DEB) are associated with failed inhibitory control. This study investigated the neural correlates of failed inhibitory control as a potential biomarker for DEB.METHODS: The study used prospective longitudinal data from the European IMAGEN study adolescent cohort. Participants completed baseline assessments (questionnaires and a brain scan [functional magnetic resonance imaging]) at 14 years of age and a follow-up assessment (questionnaires) at 16 years of age. Self-reported binge eating and/or purging were used to indicate presence of DEB. Neural correlates of failed inhibition were assessed using the stop signal task. Participants were categorized as healthy control subjects (reported no DEB at both time points), maintainers (reported DEB at both time points), recoverers (reported DEB at baseline only), and developers (reported DEB at follow-up only). Forty-three individuals per group with complete scanning data were matched on gender, age, puberty, and intelligence (N = 172).RESULTS: At baseline, despite similar task performance, incorrectly responding to stop signals (failed inhibitory control) was associated with greater recruitment of the medial prefrontal cortex and anterior cingulate cortex in the developers compared with healthy control subjects and recoverers.CONCLUSIONS: Greater recruitment of the medial prefrontal and anterior cingulate regions during failed inhibition accords with abnormal evaluation of errors contributing to DEB development. As this precedes symptom onset and is evident despite normal task performance, neural responses during failed inhibition may be a useful biomarker of vulnerability for DEB. This study highlights the potential value of prospective neuroimaging studies for identifying markers of illness before the emergence of behavior changes.",
author = "Savani Bartholdy and O'Daly, {Owen G} and Campbell, {Iain C} and Tobias Banaschewski and Gareth Barker and Bokde, {Arun L W} and Uli Bromberg and Christian B{\"u}chel and Quinlan, {Erin Burke} and Sylvane Desrivi{\`e}res and Herta Flor and Vincent Frouin and Hugh Garavan and Penny Gowland and Andreas Heinz and Bernd Ittermann and Jean-Luc Martinot and {Paill{\`e}re Martinot}, Marie-Laure and Frauke Nees and Orfanos, {Dimitri Papadopoulos} and Luise Poustka and Sarah Hohmann and Fr{\"o}hner, {Juliane H} and Smolka, {Michael N} and Henrik Walter and Robert Whelan and Gunter Schumann and Ulrike Schmidt and {IMAGEN Consortium}",
note = "Copyright {\textcopyright} 2019. Published by Elsevier Inc.",
year = "2019",
month = jun,
day = "1",
doi = "10.1016/j.biopsych.2019.01.027",
language = "English",
volume = "85",
pages = "956--965",
journal = "BIOL PSYCHIAT",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "11",

}

RIS

TY - JOUR

T1 - Neural Correlates of Failed Inhibitory Control as an Early Marker of Disordered Eating in Adolescents

AU - Bartholdy, Savani

AU - O'Daly, Owen G

AU - Campbell, Iain C

AU - Banaschewski, Tobias

AU - Barker, Gareth

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Quinlan, Erin Burke

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Frouin, Vincent

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Martinot, Jean-Luc

AU - Paillère Martinot, Marie-Laure

AU - Nees, Frauke

AU - Orfanos, Dimitri Papadopoulos

AU - Poustka, Luise

AU - Hohmann, Sarah

AU - Fröhner, Juliane H

AU - Smolka, Michael N

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

AU - Schmidt, Ulrike

AU - IMAGEN Consortium

N1 - Copyright © 2019. Published by Elsevier Inc.

PY - 2019/6/1

Y1 - 2019/6/1

N2 - BACKGROUND: Binge eating and other forms of disordered eating behavior (DEB) are associated with failed inhibitory control. This study investigated the neural correlates of failed inhibitory control as a potential biomarker for DEB.METHODS: The study used prospective longitudinal data from the European IMAGEN study adolescent cohort. Participants completed baseline assessments (questionnaires and a brain scan [functional magnetic resonance imaging]) at 14 years of age and a follow-up assessment (questionnaires) at 16 years of age. Self-reported binge eating and/or purging were used to indicate presence of DEB. Neural correlates of failed inhibition were assessed using the stop signal task. Participants were categorized as healthy control subjects (reported no DEB at both time points), maintainers (reported DEB at both time points), recoverers (reported DEB at baseline only), and developers (reported DEB at follow-up only). Forty-three individuals per group with complete scanning data were matched on gender, age, puberty, and intelligence (N = 172).RESULTS: At baseline, despite similar task performance, incorrectly responding to stop signals (failed inhibitory control) was associated with greater recruitment of the medial prefrontal cortex and anterior cingulate cortex in the developers compared with healthy control subjects and recoverers.CONCLUSIONS: Greater recruitment of the medial prefrontal and anterior cingulate regions during failed inhibition accords with abnormal evaluation of errors contributing to DEB development. As this precedes symptom onset and is evident despite normal task performance, neural responses during failed inhibition may be a useful biomarker of vulnerability for DEB. This study highlights the potential value of prospective neuroimaging studies for identifying markers of illness before the emergence of behavior changes.

AB - BACKGROUND: Binge eating and other forms of disordered eating behavior (DEB) are associated with failed inhibitory control. This study investigated the neural correlates of failed inhibitory control as a potential biomarker for DEB.METHODS: The study used prospective longitudinal data from the European IMAGEN study adolescent cohort. Participants completed baseline assessments (questionnaires and a brain scan [functional magnetic resonance imaging]) at 14 years of age and a follow-up assessment (questionnaires) at 16 years of age. Self-reported binge eating and/or purging were used to indicate presence of DEB. Neural correlates of failed inhibition were assessed using the stop signal task. Participants were categorized as healthy control subjects (reported no DEB at both time points), maintainers (reported DEB at both time points), recoverers (reported DEB at baseline only), and developers (reported DEB at follow-up only). Forty-three individuals per group with complete scanning data were matched on gender, age, puberty, and intelligence (N = 172).RESULTS: At baseline, despite similar task performance, incorrectly responding to stop signals (failed inhibitory control) was associated with greater recruitment of the medial prefrontal cortex and anterior cingulate cortex in the developers compared with healthy control subjects and recoverers.CONCLUSIONS: Greater recruitment of the medial prefrontal and anterior cingulate regions during failed inhibition accords with abnormal evaluation of errors contributing to DEB development. As this precedes symptom onset and is evident despite normal task performance, neural responses during failed inhibition may be a useful biomarker of vulnerability for DEB. This study highlights the potential value of prospective neuroimaging studies for identifying markers of illness before the emergence of behavior changes.

U2 - 10.1016/j.biopsych.2019.01.027

DO - 10.1016/j.biopsych.2019.01.027

M3 - SCORING: Journal article

C2 - 31122340

VL - 85

SP - 956

EP - 965

JO - BIOL PSYCHIAT

JF - BIOL PSYCHIAT

SN - 0006-3223

IS - 11

ER -