Neural correlates (ERP/fMRI) of voluntary selection in adult ADHD patients.
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Neural correlates (ERP/fMRI) of voluntary selection in adult ADHD patients. / Karch, Susanne; Thalmeier, Tobias; Lutz, Jürgen; Cerovecki, Anja; Opgen-Rhein, Markus; Hock, Bettina; Leicht, Gregor; Hennig-Fast, Kristina; Meindl, Thomas; Riedel, Michael; Mulert, Christoph; Pogarell, Oliver.
In: EUR ARCH PSY CLIN N, Vol. 260, No. 5, 5, 2010, p. 427-440.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Neural correlates (ERP/fMRI) of voluntary selection in adult ADHD patients.
AU - Karch, Susanne
AU - Thalmeier, Tobias
AU - Lutz, Jürgen
AU - Cerovecki, Anja
AU - Opgen-Rhein, Markus
AU - Hock, Bettina
AU - Leicht, Gregor
AU - Hennig-Fast, Kristina
AU - Meindl, Thomas
AU - Riedel, Michael
AU - Mulert, Christoph
AU - Pogarell, Oliver
PY - 2010
Y1 - 2010
N2 - Deficits in executive functions, e.g. voluntary selection, are considered central to the attention-deficit/hyperactivity disorder (ADHD). The aim of this simultaneous EEG/fMRI study was to examine associated neural correlates in ADHD patients. Patients with ADHD and healthy subjects performed an adapted go/nogo task including a voluntary selection condition allowing participants to freely decide, whether to press the response button. Electrophysiologically, response inhibition and voluntary selection led to fronto-central responses. The fMRI data revealed increased medial/lateral frontal and parietal activity during the voluntary selection task. Frontal brain responses were reduced in ADHD patients compared to controls during free responses, whereas parietal brain functions seemed to be unaffected. These results may indicate that selection processes are related to dysfunctions, predominantly in frontal brain regions in ADHD patients.
AB - Deficits in executive functions, e.g. voluntary selection, are considered central to the attention-deficit/hyperactivity disorder (ADHD). The aim of this simultaneous EEG/fMRI study was to examine associated neural correlates in ADHD patients. Patients with ADHD and healthy subjects performed an adapted go/nogo task including a voluntary selection condition allowing participants to freely decide, whether to press the response button. Electrophysiologically, response inhibition and voluntary selection led to fronto-central responses. The fMRI data revealed increased medial/lateral frontal and parietal activity during the voluntary selection task. Frontal brain responses were reduced in ADHD patients compared to controls during free responses, whereas parietal brain functions seemed to be unaffected. These results may indicate that selection processes are related to dysfunctions, predominantly in frontal brain regions in ADHD patients.
M3 - SCORING: Zeitschriftenaufsatz
VL - 260
SP - 427
EP - 440
JO - EUR ARCH PSY CLIN N
JF - EUR ARCH PSY CLIN N
SN - 0940-1334
IS - 5
M1 - 5
ER -