Neural circuitry underlying sustained attention in healthy adolescents and in ADHD symptomatology
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Neural circuitry underlying sustained attention in healthy adolescents and in ADHD symptomatology. / O'Halloran, Laura; Cao, Zhipeng; Ruddy, Kathy; Jollans, Lee; Albaugh, Matthew D; Aleni, Andrea; Potter, Alexandra S; Vahey, Nigel; Banaschewski, Tobias; Hohmann, Sarah; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Quinlan, Erin Burke; Desrivières, Sylvane; Flor, Herta; Frouin, Vincent; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Paus, Tomáš; Smolka, Michael N; Walter, Henrik; Schumann, Gunter; Garavan, Hugh; Kelly, Clare; Whelan, Robert.
In: NEUROIMAGE, Vol. 169, 01.04.2018, p. 395-406.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Neural circuitry underlying sustained attention in healthy adolescents and in ADHD symptomatology
AU - O'Halloran, Laura
AU - Cao, Zhipeng
AU - Ruddy, Kathy
AU - Jollans, Lee
AU - Albaugh, Matthew D
AU - Aleni, Andrea
AU - Potter, Alexandra S
AU - Vahey, Nigel
AU - Banaschewski, Tobias
AU - Hohmann, Sarah
AU - Bokde, Arun L W
AU - Bromberg, Uli
AU - Büchel, Christian
AU - Quinlan, Erin Burke
AU - Desrivières, Sylvane
AU - Flor, Herta
AU - Frouin, Vincent
AU - Gowland, Penny
AU - Heinz, Andreas
AU - Ittermann, Bernd
AU - Nees, Frauke
AU - Orfanos, Dimitri Papadopoulos
AU - Paus, Tomáš
AU - Smolka, Michael N
AU - Walter, Henrik
AU - Schumann, Gunter
AU - Garavan, Hugh
AU - Kelly, Clare
AU - Whelan, Robert
N1 - Copyright © 2017 Elsevier Inc. All rights reserved.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Moment-to-moment reaction time variability on tasks of attention, often quantified by intra-individual response variability (IRV), provides a good indication of the degree to which an individual is vulnerable to lapses in sustained attention. Increased IRV is a hallmark of several disorders of attention, including Attention-Deficit/Hyperactivity Disorder (ADHD). Here, task-based fMRI was used to provide the first examination of how average brain activation and functional connectivity patterns in adolescents are related to individual differences in sustained attention as measured by IRV. We computed IRV in a large sample of adolescents (n = 758) across 'Go' trials of a Stop Signal Task (SST). A data-driven, multi-step analysis approach was used to identify networks associated with low IRV (i.e., good sustained attention) and high IRV (i.e., poorer sustained attention). Low IRV was associated with greater functional segregation (i.e., stronger negative connectivity) amongst an array of brain networks, particularly between cerebellum and motor, cerebellum and prefrontal, and occipital and motor networks. In contrast, high IRV was associated with stronger positive connectivity within the motor network bilaterally and between motor and parietal, prefrontal, and limbic networks. Consistent with these observations, a separate sample of adolescents exhibiting elevated ADHD symptoms had increased fMRI activation and stronger positive connectivity within the same motor network denoting poorer sustained attention, compared to a matched asymptomatic control sample. With respect to the functional connectivity signature of low IRV, there were no statistically significant differences in networks denoting good sustained attention between the ADHD symptom group and asymptomatic control group. We propose that sustained attentional processes are facilitated by an array of neural networks working together, and provide an empirical account of how the functional role of the cerebellum extends to cognition in adolescents. This work highlights the involvement of motor cortex in the integrity of sustained attention, and suggests that atypically strong connectivity within motor networks characterizes poor attentional capacity in both typically developing and ADHD symptomatic adolescents.
AB - Moment-to-moment reaction time variability on tasks of attention, often quantified by intra-individual response variability (IRV), provides a good indication of the degree to which an individual is vulnerable to lapses in sustained attention. Increased IRV is a hallmark of several disorders of attention, including Attention-Deficit/Hyperactivity Disorder (ADHD). Here, task-based fMRI was used to provide the first examination of how average brain activation and functional connectivity patterns in adolescents are related to individual differences in sustained attention as measured by IRV. We computed IRV in a large sample of adolescents (n = 758) across 'Go' trials of a Stop Signal Task (SST). A data-driven, multi-step analysis approach was used to identify networks associated with low IRV (i.e., good sustained attention) and high IRV (i.e., poorer sustained attention). Low IRV was associated with greater functional segregation (i.e., stronger negative connectivity) amongst an array of brain networks, particularly between cerebellum and motor, cerebellum and prefrontal, and occipital and motor networks. In contrast, high IRV was associated with stronger positive connectivity within the motor network bilaterally and between motor and parietal, prefrontal, and limbic networks. Consistent with these observations, a separate sample of adolescents exhibiting elevated ADHD symptoms had increased fMRI activation and stronger positive connectivity within the same motor network denoting poorer sustained attention, compared to a matched asymptomatic control sample. With respect to the functional connectivity signature of low IRV, there were no statistically significant differences in networks denoting good sustained attention between the ADHD symptom group and asymptomatic control group. We propose that sustained attentional processes are facilitated by an array of neural networks working together, and provide an empirical account of how the functional role of the cerebellum extends to cognition in adolescents. This work highlights the involvement of motor cortex in the integrity of sustained attention, and suggests that atypically strong connectivity within motor networks characterizes poor attentional capacity in both typically developing and ADHD symptomatic adolescents.
KW - Journal Article
U2 - 10.1016/j.neuroimage.2017.12.030
DO - 10.1016/j.neuroimage.2017.12.030
M3 - SCORING: Journal article
C2 - 29274748
VL - 169
SP - 395
EP - 406
JO - NEUROIMAGE
JF - NEUROIMAGE
SN - 1053-8119
ER -