Nerve regeneration techniques respecting the special characteristics of the inferior alveolar nerve
Standard
Nerve regeneration techniques respecting the special characteristics of the inferior alveolar nerve. / Hergt, Ansgar C; Beck-Broichsitter, Benedicta E; Raethjen, Jan; Käser, Nathalie; Hülsmann, Michael; Wiltfang, Jörg; Heine, Jörg; Becker, Stephan T.
In: J CRANIO MAXILL SURG, Vol. 44, No. 9, 09.2016, p. 1381-6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Nerve regeneration techniques respecting the special characteristics of the inferior alveolar nerve
AU - Hergt, Ansgar C
AU - Beck-Broichsitter, Benedicta E
AU - Raethjen, Jan
AU - Käser, Nathalie
AU - Hülsmann, Michael
AU - Wiltfang, Jörg
AU - Heine, Jörg
AU - Becker, Stephan T
N1 - Copyright © 2016 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
PY - 2016/9
Y1 - 2016/9
N2 - PURPOSE: The aim of this study was to examine the in situ regeneration of the inferior alveolar nerve (IAN) in its bony channel, using autologous tissue in combination with a recombinant human nerve growth factor (rhNGF).MATERIALS AND METHODS: A total of 20 New Zealand rabbits were randomly divided into five groups. Following dissection of the IAN, the animals underwent reconstruction either with muscle tissue (groups 1 and 2) or with fat tissue (groups 3 and 4). In group 5 (control), the dissected nerve was resected and reconstructed by placement of the reversed autologous segment. After 2 and 4 weeks, 1 mL rhNGF was locally injected in groups 1 and 3. Nerve function was monitored by measuring the jaw-opening reflex using electromyography for a period of 24 weeks.RESULTS: Regeneration of the nerve was achieved in all groups, but preoperative threshold values were not achieved. Comparing the experimental groups to the control, there was a significant difference in favor of the autologous nerve reconstruction. Differences between the experimental groups remained statistically not significant.CONCLUSION: Regeneration of the IAN with autologous tissue is possible, but without achieving preoperative thresholds. Additional injection of a growth factor seems to improve the speed of regeneration for fat and muscle grafts.
AB - PURPOSE: The aim of this study was to examine the in situ regeneration of the inferior alveolar nerve (IAN) in its bony channel, using autologous tissue in combination with a recombinant human nerve growth factor (rhNGF).MATERIALS AND METHODS: A total of 20 New Zealand rabbits were randomly divided into five groups. Following dissection of the IAN, the animals underwent reconstruction either with muscle tissue (groups 1 and 2) or with fat tissue (groups 3 and 4). In group 5 (control), the dissected nerve was resected and reconstructed by placement of the reversed autologous segment. After 2 and 4 weeks, 1 mL rhNGF was locally injected in groups 1 and 3. Nerve function was monitored by measuring the jaw-opening reflex using electromyography for a period of 24 weeks.RESULTS: Regeneration of the nerve was achieved in all groups, but preoperative threshold values were not achieved. Comparing the experimental groups to the control, there was a significant difference in favor of the autologous nerve reconstruction. Differences between the experimental groups remained statistically not significant.CONCLUSION: Regeneration of the IAN with autologous tissue is possible, but without achieving preoperative thresholds. Additional injection of a growth factor seems to improve the speed of regeneration for fat and muscle grafts.
U2 - 10.1016/j.jcms.2016.06.020
DO - 10.1016/j.jcms.2016.06.020
M3 - SCORING: Journal article
C2 - 27435058
VL - 44
SP - 1381
EP - 1386
JO - J CRANIO MAXILL SURG
JF - J CRANIO MAXILL SURG
SN - 1010-5182
IS - 9
ER -
