Naturally occurring humoral cytotoxicity against neuroblastoma (NB) cells in healthy persons and NB patients.
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Naturally occurring humoral cytotoxicity against neuroblastoma (NB) cells in healthy persons and NB patients. / Erttmann, Rudolf; Schmitt, C; Ollert, M W; David, K; Bredehorst, R; Vogel, C W.
In: PEDIATR HEMAT ONCOL, Vol. 13, No. 6, 6, 1996, p. 545-548.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Naturally occurring humoral cytotoxicity against neuroblastoma (NB) cells in healthy persons and NB patients.
AU - Erttmann, Rudolf
AU - Schmitt, C
AU - Ollert, M W
AU - David, K
AU - Bredehorst, R
AU - Vogel, C W
PY - 1996
Y1 - 1996
N2 - A novel cytotoxic mechanism against neuroblastoma (NB) cells based on natural immunoglobulin M serum antibodies is described. The occurrence of these antibodies, which are able to induce complement-mediated cytolysis of NB cells, has been investigated in several age groups of healthy persons and in patients with NB. The cytotoxicity of serum samples has been measured in terms of propidium iodide DNA incorporation using a FACScan. The prevalence of anti-NB 1gM antibodies shows a strong age dependence characterized by a nearly complete lack in the first year of life and a steep rise up to 82% beginning with the second year of life. In the sera of 11 NB-bearing patients no cytotoxicity has been found, despite the fact that 8 of these patients were older than 1 year. These findings lead to the hypothesis that natural 1gM antibodies could play a role as an immunological control mechanism against NB.
AB - A novel cytotoxic mechanism against neuroblastoma (NB) cells based on natural immunoglobulin M serum antibodies is described. The occurrence of these antibodies, which are able to induce complement-mediated cytolysis of NB cells, has been investigated in several age groups of healthy persons and in patients with NB. The cytotoxicity of serum samples has been measured in terms of propidium iodide DNA incorporation using a FACScan. The prevalence of anti-NB 1gM antibodies shows a strong age dependence characterized by a nearly complete lack in the first year of life and a steep rise up to 82% beginning with the second year of life. In the sera of 11 NB-bearing patients no cytotoxicity has been found, despite the fact that 8 of these patients were older than 1 year. These findings lead to the hypothesis that natural 1gM antibodies could play a role as an immunological control mechanism against NB.
M3 - SCORING: Zeitschriftenaufsatz
VL - 13
SP - 545
EP - 548
JO - PEDIATR HEMAT ONCOL
JF - PEDIATR HEMAT ONCOL
SN - 0888-0018
IS - 6
M1 - 6
ER -
