Naturalistic stimulus trains evoke reproducible subicular responses both within and between animals in vivo
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Naturalistic stimulus trains evoke reproducible subicular responses both within and between animals in vivo. / Tunstall, Beth; Agnew, Zarinah K; Panzeri, Stefano; Gigg, John.
In: HIPPOCAMPUS, Vol. 20, No. 2, 02.2010, p. 252-63.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Naturalistic stimulus trains evoke reproducible subicular responses both within and between animals in vivo
AU - Tunstall, Beth
AU - Agnew, Zarinah K
AU - Panzeri, Stefano
AU - Gigg, John
PY - 2010/2
Y1 - 2010/2
N2 - Previous investigation of CA1-evoked subicular responses has used either single low-frequency pulses (LF), paired-pulses (PP), or high-frequency bursts. Here we test for the first time how subiculum responds to naturalistic stimulation trains (NSTs). We recorded CA1-evoked field potentials from dorsal rat subiculum in response to LF, PP, and two NST patterns. The latter were derived from CA1 place cell activity; NST1 contained bursts of stimuli presented in two main episodes, while the burst-patterned stimuli in NST2 were spaced more evenly. NSTs generated significantly greater field responses compared with LF or PP patterns. Response patterns to either NST were significantly correlated across trial repeats in 9 out of 10 rats, supporting a robust postsynaptic encoding of CA1 input by subiculum. Correlations between NST responses were also observed across experiments; however, these were more variable than those within experiments. The relationship between response magnitude and activation history revealed a strong correlation between magnitude and NST instantaneous frequency for NST1 but was weaker for NST2. In addition, the number of stimuli within a prior 500 ms window was a determining factor for response magnitude for both NSTs. Overall, the robust reproducibility in subicular responses within rats suggests that information within NSTs is faithfully transmitted through the CA1-subiculum axis. However, variation in response sequences across rats suggests that encoding patterns to the same input differ across the subiculum. Changes in the ratio of target bursting and regularly spiking neurons along the subicular proximodistal axis may account for this variation. The activation history of this connection also appears to be a strong determining factor for response magnitude.
AB - Previous investigation of CA1-evoked subicular responses has used either single low-frequency pulses (LF), paired-pulses (PP), or high-frequency bursts. Here we test for the first time how subiculum responds to naturalistic stimulation trains (NSTs). We recorded CA1-evoked field potentials from dorsal rat subiculum in response to LF, PP, and two NST patterns. The latter were derived from CA1 place cell activity; NST1 contained bursts of stimuli presented in two main episodes, while the burst-patterned stimuli in NST2 were spaced more evenly. NSTs generated significantly greater field responses compared with LF or PP patterns. Response patterns to either NST were significantly correlated across trial repeats in 9 out of 10 rats, supporting a robust postsynaptic encoding of CA1 input by subiculum. Correlations between NST responses were also observed across experiments; however, these were more variable than those within experiments. The relationship between response magnitude and activation history revealed a strong correlation between magnitude and NST instantaneous frequency for NST1 but was weaker for NST2. In addition, the number of stimuli within a prior 500 ms window was a determining factor for response magnitude for both NSTs. Overall, the robust reproducibility in subicular responses within rats suggests that information within NSTs is faithfully transmitted through the CA1-subiculum axis. However, variation in response sequences across rats suggests that encoding patterns to the same input differ across the subiculum. Changes in the ratio of target bursting and regularly spiking neurons along the subicular proximodistal axis may account for this variation. The activation history of this connection also appears to be a strong determining factor for response magnitude.
KW - Action Potentials
KW - Animals
KW - CA1 Region, Hippocampal/physiology
KW - Electric Stimulation/methods
KW - Electrodes, Implanted
KW - Evoked Potentials/physiology
KW - Excitatory Postsynaptic Potentials/physiology
KW - Hippocampus/physiology
KW - Linear Models
KW - Male
KW - Microelectrodes
KW - Neural Pathways/physiology
KW - Neurons/physiology
KW - Rats
KW - Rats, Wistar
KW - Space Perception/physiology
KW - Time Factors
U2 - 10.1002/hipo.20629
DO - 10.1002/hipo.20629
M3 - SCORING: Journal article
C2 - 19452520
VL - 20
SP - 252
EP - 263
JO - HIPPOCAMPUS
JF - HIPPOCAMPUS
SN - 1050-9631
IS - 2
ER -