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Natriuretic peptides in the detection of preclinical diastolic or systolic dysfunction

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Natriuretic peptides in the detection of preclinical diastolic or systolic dysfunction. / Luers, Claus; Wachter, Rolf; Kleta, Sibylle; Uhlir, Marc; Koschack, Janka; Scherer, Martin; Binder, Lutz; Herrmann-Lingen, Christoph; Zapf, Antonia; Kulle, Bettina; Kochen, Michael M; Pieske, Burkert.

In: CLIN RES CARDIOL, Vol. 99, No. 4, 04.2010, p. 217-26.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Luers, C, Wachter, R, Kleta, S, Uhlir, M, Koschack, J, Scherer, M, Binder, L, Herrmann-Lingen, C, Zapf, A, Kulle, B, Kochen, MM & Pieske, B 2010, 'Natriuretic peptides in the detection of preclinical diastolic or systolic dysfunction', CLIN RES CARDIOL, vol. 99, no. 4, pp. 217-26. https://doi.org/10.1007/s00392-009-0108-z

APA

Luers, C., Wachter, R., Kleta, S., Uhlir, M., Koschack, J., Scherer, M., Binder, L., Herrmann-Lingen, C., Zapf, A., Kulle, B., Kochen, M. M., & Pieske, B. (2010). Natriuretic peptides in the detection of preclinical diastolic or systolic dysfunction. CLIN RES CARDIOL, 99(4), 217-26. https://doi.org/10.1007/s00392-009-0108-z

Vancouver

Luers C, Wachter R, Kleta S, Uhlir M, Koschack J, Scherer M et al. Natriuretic peptides in the detection of preclinical diastolic or systolic dysfunction. CLIN RES CARDIOL. 2010 Apr;99(4):217-26. https://doi.org/10.1007/s00392-009-0108-z

Bibtex

@article{3063f766f50c43a68cee36ad790dd411,
title = "Natriuretic peptides in the detection of preclinical diastolic or systolic dysfunction",
abstract = "AIMS: The diagnostic value of natriuretic peptides in asymptomatic patients at risk for diastolic or systolic HF is controversial. We tested (1) the prevalence of preclinical LV dysfunction in an at-risk cohort; (2) the diagnostic accuracy of natriuretic peptides alone or in combination with clinical parameters for predicting asymptomatic left ventricular systolic or diastolic dysfunction.METHODS: 542 primary care patients (mean age 63 +/- 11 years, 42% female) without prediagnosed HF, but with risk factors for left ventricular dysfunction, underwent thorough cardiological workup, including echocardiography and analysis of natriuretic peptides.RESULTS: 23 patients (4%) showed reduced systolic function (EF < 50%), and 15 patients (3%) had severe diastolic dysfunction. All natriuretic peptides significantly increased with decreasing ejection fraction and with increasing degree of diastolic dysfunction. For natriuretic peptides, receiver operating characteristics analysis yielded good results for the detection of systolic dysfunction or severe diastolic dysfunction. Combining clinical parameters with natriuretic peptide data improved the diagnostic accuracy and largely reduced the number of needed screening echoes to identify patients with LV systolic or diastolic dysfunction.CONCLUSIONS: The prevalence of preclinical diastolic dysfunction is high in primary care patients at risk, but the relative prevalence of severe diastolic dysfunction and systolic dysfunction is only 7%. High-risk individuals may be screened most efficiently by using a score system incorporating clinical data and NT-proBNP.",
keywords = "Aged, Diastole, Echocardiography, Heart Failure, Diastolic, Heart Failure, Systolic, Humans, In Vitro Techniques, Mass Screening, Middle Aged, Natriuretic Peptides, Prevalence, Primary Health Care, Prospective Studies, Risk Factors, Severity of Illness Index, Systole, Ventricular Dysfunction, Left",
author = "Claus Luers and Rolf Wachter and Sibylle Kleta and Marc Uhlir and Janka Koschack and Martin Scherer and Lutz Binder and Christoph Herrmann-Lingen and Antonia Zapf and Bettina Kulle and Kochen, {Michael M} and Burkert Pieske",
year = "2010",
month = apr,
doi = "10.1007/s00392-009-0108-z",
language = "English",
volume = "99",
pages = "217--26",
journal = "CLIN RES CARDIOL",
issn = "1861-0684",
publisher = "D. Steinkopff-Verlag",
number = "4",

}

RIS

TY - JOUR

T1 - Natriuretic peptides in the detection of preclinical diastolic or systolic dysfunction

AU - Luers, Claus

AU - Wachter, Rolf

AU - Kleta, Sibylle

AU - Uhlir, Marc

AU - Koschack, Janka

AU - Scherer, Martin

AU - Binder, Lutz

AU - Herrmann-Lingen, Christoph

AU - Zapf, Antonia

AU - Kulle, Bettina

AU - Kochen, Michael M

AU - Pieske, Burkert

PY - 2010/4

Y1 - 2010/4

N2 - AIMS: The diagnostic value of natriuretic peptides in asymptomatic patients at risk for diastolic or systolic HF is controversial. We tested (1) the prevalence of preclinical LV dysfunction in an at-risk cohort; (2) the diagnostic accuracy of natriuretic peptides alone or in combination with clinical parameters for predicting asymptomatic left ventricular systolic or diastolic dysfunction.METHODS: 542 primary care patients (mean age 63 +/- 11 years, 42% female) without prediagnosed HF, but with risk factors for left ventricular dysfunction, underwent thorough cardiological workup, including echocardiography and analysis of natriuretic peptides.RESULTS: 23 patients (4%) showed reduced systolic function (EF < 50%), and 15 patients (3%) had severe diastolic dysfunction. All natriuretic peptides significantly increased with decreasing ejection fraction and with increasing degree of diastolic dysfunction. For natriuretic peptides, receiver operating characteristics analysis yielded good results for the detection of systolic dysfunction or severe diastolic dysfunction. Combining clinical parameters with natriuretic peptide data improved the diagnostic accuracy and largely reduced the number of needed screening echoes to identify patients with LV systolic or diastolic dysfunction.CONCLUSIONS: The prevalence of preclinical diastolic dysfunction is high in primary care patients at risk, but the relative prevalence of severe diastolic dysfunction and systolic dysfunction is only 7%. High-risk individuals may be screened most efficiently by using a score system incorporating clinical data and NT-proBNP.

AB - AIMS: The diagnostic value of natriuretic peptides in asymptomatic patients at risk for diastolic or systolic HF is controversial. We tested (1) the prevalence of preclinical LV dysfunction in an at-risk cohort; (2) the diagnostic accuracy of natriuretic peptides alone or in combination with clinical parameters for predicting asymptomatic left ventricular systolic or diastolic dysfunction.METHODS: 542 primary care patients (mean age 63 +/- 11 years, 42% female) without prediagnosed HF, but with risk factors for left ventricular dysfunction, underwent thorough cardiological workup, including echocardiography and analysis of natriuretic peptides.RESULTS: 23 patients (4%) showed reduced systolic function (EF < 50%), and 15 patients (3%) had severe diastolic dysfunction. All natriuretic peptides significantly increased with decreasing ejection fraction and with increasing degree of diastolic dysfunction. For natriuretic peptides, receiver operating characteristics analysis yielded good results for the detection of systolic dysfunction or severe diastolic dysfunction. Combining clinical parameters with natriuretic peptide data improved the diagnostic accuracy and largely reduced the number of needed screening echoes to identify patients with LV systolic or diastolic dysfunction.CONCLUSIONS: The prevalence of preclinical diastolic dysfunction is high in primary care patients at risk, but the relative prevalence of severe diastolic dysfunction and systolic dysfunction is only 7%. High-risk individuals may be screened most efficiently by using a score system incorporating clinical data and NT-proBNP.

KW - Aged

KW - Diastole

KW - Echocardiography

KW - Heart Failure, Diastolic

KW - Heart Failure, Systolic

KW - Humans

KW - In Vitro Techniques

KW - Mass Screening

KW - Middle Aged

KW - Natriuretic Peptides

KW - Prevalence

KW - Primary Health Care

KW - Prospective Studies

KW - Risk Factors

KW - Severity of Illness Index

KW - Systole

KW - Ventricular Dysfunction, Left

U2 - 10.1007/s00392-009-0108-z

DO - 10.1007/s00392-009-0108-z

M3 - SCORING: Journal article

C2 - 20052479

VL - 99

SP - 217

EP - 226

JO - CLIN RES CARDIOL

JF - CLIN RES CARDIOL

SN - 1861-0684

IS - 4

ER -