Research ExplorerPublicationsNAD(P)H oxidase-derived reactive oxygen species as mediators...

NAD(P)H oxidase-derived reactive oxygen species as mediators of angiotensin II signaling

Standard

NAD(P)H oxidase-derived reactive oxygen species as mediators of angiotensin II signaling. / Hanna, Ibrahim R; Taniyama, Yoshihiro; Szöcs, Katalin; Rocic, Petra; Griendling, Kathy K.

In: ANTIOXID REDOX SIGN, Vol. 4, No. 6, 12.2002, p. 899-914.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hanna, IR, Taniyama, Y, Szöcs, K, Rocic, P & Griendling, KK 2002, 'NAD(P)H oxidase-derived reactive oxygen species as mediators of angiotensin II signaling', ANTIOXID REDOX SIGN, vol. 4, no. 6, pp. 899-914. https://doi.org/10.1089/152308602762197443

APA

Hanna, I. R., Taniyama, Y., Szöcs, K., Rocic, P., & Griendling, K. K. (2002). NAD(P)H oxidase-derived reactive oxygen species as mediators of angiotensin II signaling. ANTIOXID REDOX SIGN, 4(6), 899-914. https://doi.org/10.1089/152308602762197443

Vancouver

Hanna IR, Taniyama Y, Szöcs K, Rocic P, Griendling KK. NAD(P)H oxidase-derived reactive oxygen species as mediators of angiotensin II signaling. ANTIOXID REDOX SIGN. 2002 Dec;4(6):899-914. https://doi.org/10.1089/152308602762197443

Bibtex

@article{00a7493126db45229dbeab2fc0e7d7e3,
title = "NAD(P)H oxidase-derived reactive oxygen species as mediators of angiotensin II signaling",
abstract = "Angiotensin II has been shown to participate in both physiological processes, such as sodium and water homeostasis and vascular contraction, and pathophysiological processes, including atherosclerosis and hypertension. The effects of this molecule on vascular tissue are mediated at least in part by the modification of the redox milieu of its target cells. Angiotensin II has been shown to activate the vascular NAD(P)H oxidase(s) resulting in the production of reactive oxygen species, namely superoxide and hydrogen peroxide. In this article, we review what is known about the molecular steps that link angiotensin II and its receptor to production of reactive oxygen species and subsequent redox-mediated events, focusing on the structural and functional properties of the vascular NAD(P)H oxidases and their downstream mediators. As such, we provide a framework linking angiotensin II to crucial vascular pathologies, such as hypertension, atherosclerosis, and restenosis after angioplasty, by means of the NAD(P)H-dependent oxidases and their effector molecules.",
keywords = "Angiotensin II/metabolism, Animals, Blood Vessels/enzymology, Endothelium, Vascular/metabolism, Humans, Kidney Diseases/metabolism, Muscle, Smooth, Vascular/enzymology, NADPH Oxidases/metabolism, Oxidation-Reduction, Protein Kinases/metabolism, Reactive Oxygen Species/metabolism, Signal Transduction/physiology, Transcription Factors/metabolism, Vascular Diseases/metabolism",
author = "Hanna, {Ibrahim R} and Yoshihiro Taniyama and Katalin Sz{\"o}cs and Petra Rocic and Griendling, {Kathy K}",
year = "2002",
month = dec,
doi = "10.1089/152308602762197443",
language = "English",
volume = "4",
pages = "899--914",
journal = "ANTIOXID REDOX SIGN",
issn = "1523-0864",
publisher = "Mary Ann Liebert Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - NAD(P)H oxidase-derived reactive oxygen species as mediators of angiotensin II signaling

AU - Hanna, Ibrahim R

AU - Taniyama, Yoshihiro

AU - Szöcs, Katalin

AU - Rocic, Petra

AU - Griendling, Kathy K

PY - 2002/12

Y1 - 2002/12

N2 - Angiotensin II has been shown to participate in both physiological processes, such as sodium and water homeostasis and vascular contraction, and pathophysiological processes, including atherosclerosis and hypertension. The effects of this molecule on vascular tissue are mediated at least in part by the modification of the redox milieu of its target cells. Angiotensin II has been shown to activate the vascular NAD(P)H oxidase(s) resulting in the production of reactive oxygen species, namely superoxide and hydrogen peroxide. In this article, we review what is known about the molecular steps that link angiotensin II and its receptor to production of reactive oxygen species and subsequent redox-mediated events, focusing on the structural and functional properties of the vascular NAD(P)H oxidases and their downstream mediators. As such, we provide a framework linking angiotensin II to crucial vascular pathologies, such as hypertension, atherosclerosis, and restenosis after angioplasty, by means of the NAD(P)H-dependent oxidases and their effector molecules.

AB - Angiotensin II has been shown to participate in both physiological processes, such as sodium and water homeostasis and vascular contraction, and pathophysiological processes, including atherosclerosis and hypertension. The effects of this molecule on vascular tissue are mediated at least in part by the modification of the redox milieu of its target cells. Angiotensin II has been shown to activate the vascular NAD(P)H oxidase(s) resulting in the production of reactive oxygen species, namely superoxide and hydrogen peroxide. In this article, we review what is known about the molecular steps that link angiotensin II and its receptor to production of reactive oxygen species and subsequent redox-mediated events, focusing on the structural and functional properties of the vascular NAD(P)H oxidases and their downstream mediators. As such, we provide a framework linking angiotensin II to crucial vascular pathologies, such as hypertension, atherosclerosis, and restenosis after angioplasty, by means of the NAD(P)H-dependent oxidases and their effector molecules.

KW - Angiotensin II/metabolism

KW - Animals

KW - Blood Vessels/enzymology

KW - Endothelium, Vascular/metabolism

KW - Humans

KW - Kidney Diseases/metabolism

KW - Muscle, Smooth, Vascular/enzymology

KW - NADPH Oxidases/metabolism

KW - Oxidation-Reduction

KW - Protein Kinases/metabolism

KW - Reactive Oxygen Species/metabolism

KW - Signal Transduction/physiology

KW - Transcription Factors/metabolism

KW - Vascular Diseases/metabolism

U2 - 10.1089/152308602762197443

DO - 10.1089/152308602762197443

M3 - SCORING: Journal article

C2 - 12573139

VL - 4

SP - 899

EP - 914

JO - ANTIOXID REDOX SIGN

JF - ANTIOXID REDOX SIGN

SN - 1523-0864

IS - 6

ER -