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NAADP signaling revisited

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NAADP signaling revisited. / Guse, Andreas H; Wolf, Insa; Fliegert, Ralf.

In: CURR TOP MED CHEM, Vol. 13, No. 23, 01.01.2013, p. 2978-90.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Guse, AH, Wolf, I & Fliegert, R 2013, 'NAADP signaling revisited', CURR TOP MED CHEM, vol. 13, no. 23, pp. 2978-90.

APA

Guse, A. H., Wolf, I., & Fliegert, R. (2013). NAADP signaling revisited. CURR TOP MED CHEM, 13(23), 2978-90.

Vancouver

Guse AH, Wolf I, Fliegert R. NAADP signaling revisited. CURR TOP MED CHEM. 2013 Jan 1;13(23):2978-90.

Bibtex

@article{1f2aed22476f4f06b5e624193678d3ab,
title = "NAADP signaling revisited",
abstract = "Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca²⁺ mobilizing endogenous compound known to date. Although its Ca²⁺ releasing activity has been demonstrated in many cell types and in response to different extracellular stimuli, several aspects of NAADP signaling are unclear. This overview focuses on the controversial aspects and reviews NAADP's role as second messenger: endogenous concentrations and its receptor-mediated alterations, metabolism, and potential organelle and ion channel targets. Finally, the role of NAADP as Ca²⁺ trigger is discussed by reviewing the development of local into global Ca²⁺ signals evoked by NAADP.",
author = "Guse, {Andreas H} and Insa Wolf and Ralf Fliegert",
year = "2013",
month = jan,
day = "1",
language = "English",
volume = "13",
pages = "2978--90",
journal = "CURR TOP MED CHEM",
issn = "1568-0266",
publisher = "Bentham Science Publishers B.V.",
number = "23",

}

RIS

TY - JOUR

T1 - NAADP signaling revisited

AU - Guse, Andreas H

AU - Wolf, Insa

AU - Fliegert, Ralf

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca²⁺ mobilizing endogenous compound known to date. Although its Ca²⁺ releasing activity has been demonstrated in many cell types and in response to different extracellular stimuli, several aspects of NAADP signaling are unclear. This overview focuses on the controversial aspects and reviews NAADP's role as second messenger: endogenous concentrations and its receptor-mediated alterations, metabolism, and potential organelle and ion channel targets. Finally, the role of NAADP as Ca²⁺ trigger is discussed by reviewing the development of local into global Ca²⁺ signals evoked by NAADP.

AB - Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca²⁺ mobilizing endogenous compound known to date. Although its Ca²⁺ releasing activity has been demonstrated in many cell types and in response to different extracellular stimuli, several aspects of NAADP signaling are unclear. This overview focuses on the controversial aspects and reviews NAADP's role as second messenger: endogenous concentrations and its receptor-mediated alterations, metabolism, and potential organelle and ion channel targets. Finally, the role of NAADP as Ca²⁺ trigger is discussed by reviewing the development of local into global Ca²⁺ signals evoked by NAADP.

M3 - SCORING: Journal article

C2 - 24171770

VL - 13

SP - 2978

EP - 2990

JO - CURR TOP MED CHEM

JF - CURR TOP MED CHEM

SN - 1568-0266

IS - 23

ER -