Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics

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Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics. / Kneussel, Matthias; Wagner, Wolfgang.

In: NAT REV NEUROSCI, Vol. 14, No. 4, 01.04.2013, p. 233-47.

Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

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@article{44a7181347c7446da02c4640585d471f,
title = "Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics",
abstract = "Myosins are a large family of actin-based cytoskeletal motors that use energy derived from ATP hydrolysis to generate movement and force. Myosins of classes II, V and VI have specific pre- and postsynaptic roles that are required for synapse function. They also facilitate several forms of synaptic plasticity. Interestingly, the myosins of these classes differ markedly in important aspects of their molecular mechanisms of function. Accordingly, their major roles at synapses are diverse and include the regulation of actin cytoskeleton dynamics in dendritic spines and powering of synaptic cargo transport.",
keywords = "Actin Cytoskeleton, Animals, Dendritic Spines, Humans, Myosins, Neuronal Plasticity, Neurons, Protein Transport, Synapses",
author = "Matthias Kneussel and Wolfgang Wagner",
year = "2013",
month = apr,
day = "1",
doi = "10.1038/nrn3445",
language = "English",
volume = "14",
pages = "233--47",
journal = "NAT REV NEUROSCI",
issn = "1471-003X",
publisher = "NATURE PUBLISHING GROUP",
number = "4",

}

RIS

TY - JOUR

T1 - Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics

AU - Kneussel, Matthias

AU - Wagner, Wolfgang

PY - 2013/4/1

Y1 - 2013/4/1

N2 - Myosins are a large family of actin-based cytoskeletal motors that use energy derived from ATP hydrolysis to generate movement and force. Myosins of classes II, V and VI have specific pre- and postsynaptic roles that are required for synapse function. They also facilitate several forms of synaptic plasticity. Interestingly, the myosins of these classes differ markedly in important aspects of their molecular mechanisms of function. Accordingly, their major roles at synapses are diverse and include the regulation of actin cytoskeleton dynamics in dendritic spines and powering of synaptic cargo transport.

AB - Myosins are a large family of actin-based cytoskeletal motors that use energy derived from ATP hydrolysis to generate movement and force. Myosins of classes II, V and VI have specific pre- and postsynaptic roles that are required for synapse function. They also facilitate several forms of synaptic plasticity. Interestingly, the myosins of these classes differ markedly in important aspects of their molecular mechanisms of function. Accordingly, their major roles at synapses are diverse and include the regulation of actin cytoskeleton dynamics in dendritic spines and powering of synaptic cargo transport.

KW - Actin Cytoskeleton

KW - Animals

KW - Dendritic Spines

KW - Humans

KW - Myosins

KW - Neuronal Plasticity

KW - Neurons

KW - Protein Transport

KW - Synapses

U2 - 10.1038/nrn3445

DO - 10.1038/nrn3445

M3 - SCORING: Journal article

C2 - 23481482

VL - 14

SP - 233

EP - 247

JO - NAT REV NEUROSCI

JF - NAT REV NEUROSCI

SN - 1471-003X

IS - 4

ER -