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Muskelin regulates actin filament- and microtubule-based GABA(A) receptor transport in neurons.

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Muskelin regulates actin filament- and microtubule-based GABA(A) receptor transport in neurons. / Heisler, Frank; Löbrich, Sven; Pechmann, Yvonne; Maier, Nikolaus; Zivkovic, Aleksandar R; Tokito, Mariko; Hausrat, Torben; Schweizer, Michaela; Bähring, Robert; Holzbaur, Erika L F; Schmitz, Dietmar; Kneussel, Matthias.

In: NEURON, Vol. 70, No. 1, 1, 2011, p. 66-81.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Heisler, F, Löbrich, S, Pechmann, Y, Maier, N, Zivkovic, AR, Tokito, M, Hausrat, T, Schweizer, M, Bähring, R, Holzbaur, ELF, Schmitz, D & Kneussel, M 2011, 'Muskelin regulates actin filament- and microtubule-based GABA(A) receptor transport in neurons.', NEURON, vol. 70, no. 1, 1, pp. 66-81. <http://www.ncbi.nlm.nih.gov/pubmed/21482357?dopt=Citation>

APA

Heisler, F., Löbrich, S., Pechmann, Y., Maier, N., Zivkovic, A. R., Tokito, M., Hausrat, T., Schweizer, M., Bähring, R., Holzbaur, E. L. F., Schmitz, D., & Kneussel, M. (2011). Muskelin regulates actin filament- and microtubule-based GABA(A) receptor transport in neurons. NEURON, 70(1), 66-81. [1]. http://www.ncbi.nlm.nih.gov/pubmed/21482357?dopt=Citation

Vancouver

Heisler F, Löbrich S, Pechmann Y, Maier N, Zivkovic AR, Tokito M et al. Muskelin regulates actin filament- and microtubule-based GABA(A) receptor transport in neurons. NEURON. 2011;70(1):66-81. 1.

Bibtex

@article{8022ae8f709e4dfca08085b8a1c39f30,
title = "Muskelin regulates actin filament- and microtubule-based GABA(A) receptor transport in neurons.",
abstract = "Intracellular transport regulates protein turnover including endocytosis. Because of the spatial segregation of F-actin and microtubules, internalized cargo vesicles need to employ myosin and dynein motors to traverse both cytoskeletal compartments. Factors specifying cargo delivery across both tracks remain unknown. We identified muskelin to interconnect retrograde F-actin- and microtubule-dependent GABA(A) receptor (GABA(A)R) trafficking. GABA(A)Rs regulate synaptic transmission, plasticity, and network oscillations. GABA(A)R ?1 and muskelin interact directly, undergo neuronal cotransport, and associate with myosin VI or dynein motor complexes in subsequent steps of GABA(A)R endocytosis. Inhibition of either transport route selectively interferes with receptor internalization or degradation. Newly generated muskelin KO mice display depletion of both transport steps and a high-frequency ripple oscillation phenotype. A diluted coat color of muskelin KOs further suggests muskelin transport functions beyond neurons. Our data suggest the concept that specific trafficking factors help cargoes to traverse both F-actin and microtubule compartments, thereby regulating their fate.",
keywords = "Animals, Humans, Mice, Mice, Inbred C57BL, Mice, Knockout, HEK293 Cells, Neurons/*metabolism, Mice, 129 Strain, Actin Cytoskeleton/*metabolism, Cell Adhesion Molecules/*physiology, Intracellular Signaling Peptides and Proteins/*physiology, Microtubules/*metabolism, Protein Transport/physiology, Receptors, GABA-A/*metabolism, Animals, Humans, Mice, Mice, Inbred C57BL, Mice, Knockout, HEK293 Cells, Neurons/*metabolism, Mice, 129 Strain, Actin Cytoskeleton/*metabolism, Cell Adhesion Molecules/*physiology, Intracellular Signaling Peptides and Proteins/*physiology, Microtubules/*metabolism, Protein Transport/physiology, Receptors, GABA-A/*metabolism",
author = "Frank Heisler and Sven L{\"o}brich and Yvonne Pechmann and Nikolaus Maier and Zivkovic, {Aleksandar R} and Mariko Tokito and Torben Hausrat and Michaela Schweizer and Robert B{\"a}hring and Holzbaur, {Erika L F} and Dietmar Schmitz and Matthias Kneussel",
year = "2011",
language = "English",
volume = "70",
pages = "66--81",
journal = "NEURON",
issn = "0896-6273",
publisher = "Cell Press",
number = "1",

}

RIS

TY - JOUR

T1 - Muskelin regulates actin filament- and microtubule-based GABA(A) receptor transport in neurons.

AU - Heisler, Frank

AU - Löbrich, Sven

AU - Pechmann, Yvonne

AU - Maier, Nikolaus

AU - Zivkovic, Aleksandar R

AU - Tokito, Mariko

AU - Hausrat, Torben

AU - Schweizer, Michaela

AU - Bähring, Robert

AU - Holzbaur, Erika L F

AU - Schmitz, Dietmar

AU - Kneussel, Matthias

PY - 2011

Y1 - 2011

N2 - Intracellular transport regulates protein turnover including endocytosis. Because of the spatial segregation of F-actin and microtubules, internalized cargo vesicles need to employ myosin and dynein motors to traverse both cytoskeletal compartments. Factors specifying cargo delivery across both tracks remain unknown. We identified muskelin to interconnect retrograde F-actin- and microtubule-dependent GABA(A) receptor (GABA(A)R) trafficking. GABA(A)Rs regulate synaptic transmission, plasticity, and network oscillations. GABA(A)R ?1 and muskelin interact directly, undergo neuronal cotransport, and associate with myosin VI or dynein motor complexes in subsequent steps of GABA(A)R endocytosis. Inhibition of either transport route selectively interferes with receptor internalization or degradation. Newly generated muskelin KO mice display depletion of both transport steps and a high-frequency ripple oscillation phenotype. A diluted coat color of muskelin KOs further suggests muskelin transport functions beyond neurons. Our data suggest the concept that specific trafficking factors help cargoes to traverse both F-actin and microtubule compartments, thereby regulating their fate.

AB - Intracellular transport regulates protein turnover including endocytosis. Because of the spatial segregation of F-actin and microtubules, internalized cargo vesicles need to employ myosin and dynein motors to traverse both cytoskeletal compartments. Factors specifying cargo delivery across both tracks remain unknown. We identified muskelin to interconnect retrograde F-actin- and microtubule-dependent GABA(A) receptor (GABA(A)R) trafficking. GABA(A)Rs regulate synaptic transmission, plasticity, and network oscillations. GABA(A)R ?1 and muskelin interact directly, undergo neuronal cotransport, and associate with myosin VI or dynein motor complexes in subsequent steps of GABA(A)R endocytosis. Inhibition of either transport route selectively interferes with receptor internalization or degradation. Newly generated muskelin KO mice display depletion of both transport steps and a high-frequency ripple oscillation phenotype. A diluted coat color of muskelin KOs further suggests muskelin transport functions beyond neurons. Our data suggest the concept that specific trafficking factors help cargoes to traverse both F-actin and microtubule compartments, thereby regulating their fate.

KW - Animals

KW - Humans

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - HEK293 Cells

KW - Neurons/metabolism

KW - Mice, 129 Strain

KW - Actin Cytoskeleton/metabolism

KW - Cell Adhesion Molecules/physiology

KW - Intracellular Signaling Peptides and Proteins/physiology

KW - Microtubules/metabolism

KW - Protein Transport/physiology

KW - Receptors, GABA-A/metabolism

KW - Animals

KW - Humans

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - HEK293 Cells

KW - Neurons/metabolism

KW - Mice, 129 Strain

KW - Actin Cytoskeleton/metabolism

KW - Cell Adhesion Molecules/physiology

KW - Intracellular Signaling Peptides and Proteins/physiology

KW - Microtubules/metabolism

KW - Protein Transport/physiology

KW - Receptors, GABA-A/metabolism

M3 - SCORING: Journal article

VL - 70

SP - 66

EP - 81

JO - NEURON

JF - NEURON

SN - 0896-6273

IS - 1

M1 - 1

ER -