Multisite Thrombosis in a Patient with Paroxysmal Nocturnal Hemoglobinuria
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Multisite Thrombosis in a Patient with Paroxysmal Nocturnal Hemoglobinuria. / Beckmann, Lennart; Faizy, Tobias; Flottmann, Fabian Alexander; Fiehler, Jens; Bokemeyer, Carsten; Well, Lennart; Beitzen-Heineke, Antonia; Langer, Florian.
In: HAMOSTASEOLOGIE, 09.02.2024.Research output: SCORING: Contribution to journal › Short publication › Research › peer-review
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TY - JOUR
T1 - Multisite Thrombosis in a Patient with Paroxysmal Nocturnal Hemoglobinuria
AU - Beckmann, Lennart
AU - Faizy, Tobias
AU - Flottmann, Fabian Alexander
AU - Fiehler, Jens
AU - Bokemeyer, Carsten
AU - Well, Lennart
AU - Beitzen-Heineke, Antonia
AU - Langer, Florian
PY - 2024/2/9
Y1 - 2024/2/9
N2 - Paroxysmal nocturnal hemoglobinuria (PNH) is an extremely rare bone marrow disorder caused by acquired mutations in the phosphatidylinositol glycan class A gene, which lead to a partial or total loss of the cellular complement regulators CD55 and CD59.1 In addition to complement-mediated hemolysis and cytopenia, venous and arterial thromboses at multiple and/or unusual sites are a common complication and occur in up to 44% of patients in historic PNH cohorts.1 2.
AB - Paroxysmal nocturnal hemoglobinuria (PNH) is an extremely rare bone marrow disorder caused by acquired mutations in the phosphatidylinositol glycan class A gene, which lead to a partial or total loss of the cellular complement regulators CD55 and CD59.1 In addition to complement-mediated hemolysis and cytopenia, venous and arterial thromboses at multiple and/or unusual sites are a common complication and occur in up to 44% of patients in historic PNH cohorts.1 2.
U2 - 10.1055/a-2231-5277
DO - 10.1055/a-2231-5277
M3 - Short publication
C2 - 38335997
JO - HAMOSTASEOLOGIE
JF - HAMOSTASEOLOGIE
SN - 0720-9355
ER -