Multiple central giant cell granuloma of the jaws: diagnostic signposts of Noonan syndrome and RASopathy
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Multiple central giant cell granuloma of the jaws: diagnostic signposts of Noonan syndrome and RASopathy. / Friedrich, Reinhard E; Rutkowski, Rico; Gosau, Martin.
In: ORAL MAXILLOFAC SURG, Vol. 28, No. 2, 06.2024, p. 991-997.Research output: SCORING: Contribution to journal › Case report › Research › peer-review
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TY - JOUR
T1 - Multiple central giant cell granuloma of the jaws: diagnostic signposts of Noonan syndrome and RASopathy
AU - Friedrich, Reinhard E
AU - Rutkowski, Rico
AU - Gosau, Martin
N1 - © 2024. The Author(s).
PY - 2024/6
Y1 - 2024/6
N2 - Noonan syndrome (NS) is a phenotypically variable inherited multi-system disorder. Maxillofacial findings can be diagnostic, especially in the evaluation of discrete facial dysmorphia. Diagnostic landmark findings of therapeutic relevance for the jaws such as central giant cell granuloma (CGCG) are rare in NS. However, recent molecular genetic studies indicate that these rare, benign lesions are neoplasms and more common in specific syndromes grouped under the umbrella term RASopathies. A specialist surgical diagnosis can be helpful in identifying the underlying disease. This report outlines diagnosis and treatment of a case of CGCG for which jaw diagnosis became the key to identifying a syndromic disease.
AB - Noonan syndrome (NS) is a phenotypically variable inherited multi-system disorder. Maxillofacial findings can be diagnostic, especially in the evaluation of discrete facial dysmorphia. Diagnostic landmark findings of therapeutic relevance for the jaws such as central giant cell granuloma (CGCG) are rare in NS. However, recent molecular genetic studies indicate that these rare, benign lesions are neoplasms and more common in specific syndromes grouped under the umbrella term RASopathies. A specialist surgical diagnosis can be helpful in identifying the underlying disease. This report outlines diagnosis and treatment of a case of CGCG for which jaw diagnosis became the key to identifying a syndromic disease.
U2 - 10.1007/s10006-024-01209-2
DO - 10.1007/s10006-024-01209-2
M3 - Case report
C2 - 38347383
VL - 28
SP - 991
EP - 997
JO - ORAL MAXILLOFAC SURG
JF - ORAL MAXILLOFAC SURG
SN - 1865-1550
IS - 2
ER -