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Multiomic immune clockworks of pregnancy

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Multiomic immune clockworks of pregnancy. / Peterson, Laura S; Stelzer, Ina A; Tsai, Amy S; Ghaemi, Mohammad S; Han, Xiaoyuan; Ando, Kazuo; Winn, Virginia D; Martinez, Nadine R; Contrepois, Kevin; Moufarrej, Mira N; Quake, Stephen; Relman, David A; Snyder, Michael P; Shaw, Gary M; Stevenson, David K; Wong, Ronald J; Arck, Petra; Angst, Martin S; Aghaeepour, Nima; Gaudilliere, Brice.

In: SEMIN IMMUNOPATHOL, Vol. 42, No. 4, 08.2020, p. 397-412.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Peterson, LS, Stelzer, IA, Tsai, AS, Ghaemi, MS, Han, X, Ando, K, Winn, VD, Martinez, NR, Contrepois, K, Moufarrej, MN, Quake, S, Relman, DA, Snyder, MP, Shaw, GM, Stevenson, DK, Wong, RJ, Arck, P, Angst, MS, Aghaeepour, N & Gaudilliere, B 2020, 'Multiomic immune clockworks of pregnancy', SEMIN IMMUNOPATHOL, vol. 42, no. 4, pp. 397-412. https://doi.org/10.1007/s00281-019-00772-1

APA

Peterson, L. S., Stelzer, I. A., Tsai, A. S., Ghaemi, M. S., Han, X., Ando, K., Winn, V. D., Martinez, N. R., Contrepois, K., Moufarrej, M. N., Quake, S., Relman, D. A., Snyder, M. P., Shaw, G. M., Stevenson, D. K., Wong, R. J., Arck, P., Angst, M. S., Aghaeepour, N., & Gaudilliere, B. (2020). Multiomic immune clockworks of pregnancy. SEMIN IMMUNOPATHOL, 42(4), 397-412. https://doi.org/10.1007/s00281-019-00772-1

Vancouver

Peterson LS, Stelzer IA, Tsai AS, Ghaemi MS, Han X, Ando K et al. Multiomic immune clockworks of pregnancy. SEMIN IMMUNOPATHOL. 2020 Aug;42(4):397-412. https://doi.org/10.1007/s00281-019-00772-1

Bibtex

@article{bfe88ce6ada548a7836f492d03c4b8c2,
title = "Multiomic immune clockworks of pregnancy",
abstract = "Preterm birth is the leading cause of mortality in children under the age of five worldwide. Despite major efforts, we still lack the ability to accurately predict and effectively prevent preterm birth. While multiple factors contribute to preterm labor, dysregulations of immunological adaptations required for the maintenance of a healthy pregnancy is at its pathophysiological core. Consequently, a precise understanding of these chronologically paced immune adaptations and of the biological pacemakers that synchronize the pregnancy {"}immune clock{"} is a critical first step towards identifying deviations that are hallmarks of peterm birth. Here, we will review key elements of the fetal, placental, and maternal pacemakers that program the immune clock of pregnancy. We will then emphasize multiomic studies that enable a more integrated view of pregnancy-related immune adaptations. Such multiomic assessments can strengthen the biological plausibility of immunological findings and increase the power of biological signatures predictive of preterm birth.",
author = "Peterson, {Laura S} and Stelzer, {Ina A} and Tsai, {Amy S} and Ghaemi, {Mohammad S} and Xiaoyuan Han and Kazuo Ando and Winn, {Virginia D} and Martinez, {Nadine R} and Kevin Contrepois and Moufarrej, {Mira N} and Stephen Quake and Relman, {David A} and Snyder, {Michael P} and Shaw, {Gary M} and Stevenson, {David K} and Wong, {Ronald J} and Petra Arck and Angst, {Martin S} and Nima Aghaeepour and Brice Gaudilliere",
year = "2020",
month = aug,
doi = "10.1007/s00281-019-00772-1",
language = "English",
volume = "42",
pages = "397--412",
journal = "SEMIN IMMUNOPATHOL",
issn = "1863-2297",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - Multiomic immune clockworks of pregnancy

AU - Peterson, Laura S

AU - Stelzer, Ina A

AU - Tsai, Amy S

AU - Ghaemi, Mohammad S

AU - Han, Xiaoyuan

AU - Ando, Kazuo

AU - Winn, Virginia D

AU - Martinez, Nadine R

AU - Contrepois, Kevin

AU - Moufarrej, Mira N

AU - Quake, Stephen

AU - Relman, David A

AU - Snyder, Michael P

AU - Shaw, Gary M

AU - Stevenson, David K

AU - Wong, Ronald J

AU - Arck, Petra

AU - Angst, Martin S

AU - Aghaeepour, Nima

AU - Gaudilliere, Brice

PY - 2020/8

Y1 - 2020/8

N2 - Preterm birth is the leading cause of mortality in children under the age of five worldwide. Despite major efforts, we still lack the ability to accurately predict and effectively prevent preterm birth. While multiple factors contribute to preterm labor, dysregulations of immunological adaptations required for the maintenance of a healthy pregnancy is at its pathophysiological core. Consequently, a precise understanding of these chronologically paced immune adaptations and of the biological pacemakers that synchronize the pregnancy "immune clock" is a critical first step towards identifying deviations that are hallmarks of peterm birth. Here, we will review key elements of the fetal, placental, and maternal pacemakers that program the immune clock of pregnancy. We will then emphasize multiomic studies that enable a more integrated view of pregnancy-related immune adaptations. Such multiomic assessments can strengthen the biological plausibility of immunological findings and increase the power of biological signatures predictive of preterm birth.

AB - Preterm birth is the leading cause of mortality in children under the age of five worldwide. Despite major efforts, we still lack the ability to accurately predict and effectively prevent preterm birth. While multiple factors contribute to preterm labor, dysregulations of immunological adaptations required for the maintenance of a healthy pregnancy is at its pathophysiological core. Consequently, a precise understanding of these chronologically paced immune adaptations and of the biological pacemakers that synchronize the pregnancy "immune clock" is a critical first step towards identifying deviations that are hallmarks of peterm birth. Here, we will review key elements of the fetal, placental, and maternal pacemakers that program the immune clock of pregnancy. We will then emphasize multiomic studies that enable a more integrated view of pregnancy-related immune adaptations. Such multiomic assessments can strengthen the biological plausibility of immunological findings and increase the power of biological signatures predictive of preterm birth.

U2 - 10.1007/s00281-019-00772-1

DO - 10.1007/s00281-019-00772-1

M3 - SCORING: Review article

C2 - 32020337

VL - 42

SP - 397

EP - 412

JO - SEMIN IMMUNOPATHOL

JF - SEMIN IMMUNOPATHOL

SN - 1863-2297

IS - 4

ER -