Multidrug-Resistant Tuberculosis Complicated by Nosocomial Infection with Multidrug-Resistant Enterobacteriaceae
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Multidrug-Resistant Tuberculosis Complicated by Nosocomial Infection with Multidrug-Resistant Enterobacteriaceae. / Gröschel, Matthias I; Omansen, Till F.; de Lange, Wiel; van der Werf, Tjip S; Lokate, Mariëtte; Bathoorn, Erik; Akkerman, Onno W; Stienstra, Ymkje.
In: AM J TROP MED HYG, Vol. 94, No. 3, 03.2016, p. 517-518.Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
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TY - JOUR
T1 - Multidrug-Resistant Tuberculosis Complicated by Nosocomial Infection with Multidrug-Resistant Enterobacteriaceae
AU - Gröschel, Matthias I
AU - Omansen, Till F.
AU - de Lange, Wiel
AU - van der Werf, Tjip S
AU - Lokate, Mariëtte
AU - Bathoorn, Erik
AU - Akkerman, Onno W
AU - Stienstra, Ymkje
N1 - © The American Society of Tropical Medicine and Hygiene.
PY - 2016/3
Y1 - 2016/3
N2 - Treatment of mycobacterial diseases such as tuberculosis (TB) entails long and intense antimicrobial therapy. TB patients are at risk of coinfection with other multidrug-resistant bacteria, such as those from Enterobacteriaceae family, because of antimicrobial selection pressure and nosocomial transmission during prolonged hospital admission. Here, we report on two patients treated for multidrug-resistant TB, who developed severe sepsis due to an extended spectrum β-lactamase producing organism. Diagnostic culture identified the venous access port as source, and upon surgical removal and antimicrobial therapy rapid clinical improvement was achieved. Increased awareness and knowledge on the prevalence of multi-resistant Enterobacteriaceae is needed, notably in TB centers, to provide a safe hospital environment to our patients.
AB - Treatment of mycobacterial diseases such as tuberculosis (TB) entails long and intense antimicrobial therapy. TB patients are at risk of coinfection with other multidrug-resistant bacteria, such as those from Enterobacteriaceae family, because of antimicrobial selection pressure and nosocomial transmission during prolonged hospital admission. Here, we report on two patients treated for multidrug-resistant TB, who developed severe sepsis due to an extended spectrum β-lactamase producing organism. Diagnostic culture identified the venous access port as source, and upon surgical removal and antimicrobial therapy rapid clinical improvement was achieved. Increased awareness and knowledge on the prevalence of multi-resistant Enterobacteriaceae is needed, notably in TB centers, to provide a safe hospital environment to our patients.
KW - Adult
KW - Anti-Bacterial Agents/pharmacology
KW - Antitubercular Agents/administration & dosage
KW - Cross Infection
KW - Enterobacteriaceae
KW - Enterobacteriaceae Infections/etiology
KW - Female
KW - Humans
KW - Tuberculosis, Multidrug-Resistant/complications
U2 - 10.4269/ajtmh.15-0690
DO - 10.4269/ajtmh.15-0690
M3 - Other (editorial matter etc.)
C2 - 26755567
VL - 94
SP - 517
EP - 518
JO - AM J TROP MED HYG
JF - AM J TROP MED HYG
SN - 0002-9637
IS - 3
ER -