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Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's disease.

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Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's disease. / Teipel, Stefan J; Ewers, Michael; Wolf, Stefanie; Jessen, Frank; Kölsch, Heike; Arlt, Sönke; Luckhaus, Christian; Schönknecht, Peter; Schmidtke, Klaus; Heuser, Isabella; Frölich, Lutz; Gabriele, Ende; Pantel, Johannes; Wiltfang, Jens; Rakebrandt, Fabian; Peters, Oliver; Born, Christine; Kornhuber, Johannes; Hampel, Harald.

In: PSYCHIAT RES, Vol. 182, No. 3, 3, 2010, p. 244-250.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Teipel, SJ, Ewers, M, Wolf, S, Jessen, F, Kölsch, H, Arlt, S, Luckhaus, C, Schönknecht, P, Schmidtke, K, Heuser, I, Frölich, L, Gabriele, E, Pantel, J, Wiltfang, J, Rakebrandt, F, Peters, O, Born, C, Kornhuber, J & Hampel, H 2010, 'Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's disease.', PSYCHIAT RES, vol. 182, no. 3, 3, pp. 244-250. <http://www.ncbi.nlm.nih.gov/pubmed/20493672?dopt=Citation>

APA

Teipel, S. J., Ewers, M., Wolf, S., Jessen, F., Kölsch, H., Arlt, S., Luckhaus, C., Schönknecht, P., Schmidtke, K., Heuser, I., Frölich, L., Gabriele, E., Pantel, J., Wiltfang, J., Rakebrandt, F., Peters, O., Born, C., Kornhuber, J., & Hampel, H. (2010). Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's disease. PSYCHIAT RES, 182(3), 244-250. [3]. http://www.ncbi.nlm.nih.gov/pubmed/20493672?dopt=Citation

Vancouver

Teipel SJ, Ewers M, Wolf S, Jessen F, Kölsch H, Arlt S et al. Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's disease. PSYCHIAT RES. 2010;182(3):244-250. 3.

Bibtex

@article{c631e542c64c4f17a92afcc895928e87,
title = "Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's disease.",
abstract = "Magnetic resonance imaging (MRI)-based volumetry of medial temporal lobe regions is among the best established biomarker candidates of Alzheimer's disease (AD) to date. This study assessed the effect of multicentre variability of MRI-based hippocampus and amygdala volumetry on the discrimination between patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) and on the association of morphological changes with ApoE4 genotype and cognition. We studied 113 patients with clinically probable AD and 150 patients with amnestic MCI using high-resolution MRI scans obtained at 12 clinical sites. We determined effect sizes of group discrimination and random effects linear models, considering multicentre variability. Hippocampus and amygdala volumes were significantly reduced in AD compared with MCI patients using data pooled across centres. Multicentre variability did not significantly affect the power to detect a volume difference between AD and MCI patients. Among cognitive measures, delayed recall of verbal and non-verbal material was significantly correlated with hippocampus and amygdala volumes. Amygdala and hippocampus volumes were not associated with ApoE4 genotype in AD or MCI. Our data indicate that multicentre acquisition of MRI data using manual volumetry is reliable and feasible for cross-sectional diagnostic studies, and they replicate essential findings from smaller scale monocentre studies.",
author = "Teipel, {Stefan J} and Michael Ewers and Stefanie Wolf and Frank Jessen and Heike K{\"o}lsch and S{\"o}nke Arlt and Christian Luckhaus and Peter Sch{\"o}nknecht and Klaus Schmidtke and Isabella Heuser and Lutz Fr{\"o}lich and Ende Gabriele and Johannes Pantel and Jens Wiltfang and Fabian Rakebrandt and Oliver Peters and Christine Born and Johannes Kornhuber and Harald Hampel",
year = "2010",
language = "Deutsch",
volume = "182",
pages = "244--250",
journal = "PSYCHIAT RES",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's disease.

AU - Teipel, Stefan J

AU - Ewers, Michael

AU - Wolf, Stefanie

AU - Jessen, Frank

AU - Kölsch, Heike

AU - Arlt, Sönke

AU - Luckhaus, Christian

AU - Schönknecht, Peter

AU - Schmidtke, Klaus

AU - Heuser, Isabella

AU - Frölich, Lutz

AU - Gabriele, Ende

AU - Pantel, Johannes

AU - Wiltfang, Jens

AU - Rakebrandt, Fabian

AU - Peters, Oliver

AU - Born, Christine

AU - Kornhuber, Johannes

AU - Hampel, Harald

PY - 2010

Y1 - 2010

N2 - Magnetic resonance imaging (MRI)-based volumetry of medial temporal lobe regions is among the best established biomarker candidates of Alzheimer's disease (AD) to date. This study assessed the effect of multicentre variability of MRI-based hippocampus and amygdala volumetry on the discrimination between patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) and on the association of morphological changes with ApoE4 genotype and cognition. We studied 113 patients with clinically probable AD and 150 patients with amnestic MCI using high-resolution MRI scans obtained at 12 clinical sites. We determined effect sizes of group discrimination and random effects linear models, considering multicentre variability. Hippocampus and amygdala volumes were significantly reduced in AD compared with MCI patients using data pooled across centres. Multicentre variability did not significantly affect the power to detect a volume difference between AD and MCI patients. Among cognitive measures, delayed recall of verbal and non-verbal material was significantly correlated with hippocampus and amygdala volumes. Amygdala and hippocampus volumes were not associated with ApoE4 genotype in AD or MCI. Our data indicate that multicentre acquisition of MRI data using manual volumetry is reliable and feasible for cross-sectional diagnostic studies, and they replicate essential findings from smaller scale monocentre studies.

AB - Magnetic resonance imaging (MRI)-based volumetry of medial temporal lobe regions is among the best established biomarker candidates of Alzheimer's disease (AD) to date. This study assessed the effect of multicentre variability of MRI-based hippocampus and amygdala volumetry on the discrimination between patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) and on the association of morphological changes with ApoE4 genotype and cognition. We studied 113 patients with clinically probable AD and 150 patients with amnestic MCI using high-resolution MRI scans obtained at 12 clinical sites. We determined effect sizes of group discrimination and random effects linear models, considering multicentre variability. Hippocampus and amygdala volumes were significantly reduced in AD compared with MCI patients using data pooled across centres. Multicentre variability did not significantly affect the power to detect a volume difference between AD and MCI patients. Among cognitive measures, delayed recall of verbal and non-verbal material was significantly correlated with hippocampus and amygdala volumes. Amygdala and hippocampus volumes were not associated with ApoE4 genotype in AD or MCI. Our data indicate that multicentre acquisition of MRI data using manual volumetry is reliable and feasible for cross-sectional diagnostic studies, and they replicate essential findings from smaller scale monocentre studies.

M3 - SCORING: Zeitschriftenaufsatz

VL - 182

SP - 244

EP - 250

JO - PSYCHIAT RES

JF - PSYCHIAT RES

SN - 0165-1781

IS - 3

M1 - 3

ER -