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Mucin 5AC expression is common but unrelated to tumor progression in pancreatic adenocarcinoma

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Mucin 5AC expression is common but unrelated to tumor progression in pancreatic adenocarcinoma. / Dwertmann Rico, Sebastian; Büscheck, Franziska; Dum, David; Luebke, Andreas M; Kluth, Martina; Hube-Magg, Claudia; Hinsch, Andrea; Höflmayer, Doris; Perez, Daniel; Izbicki, Jakob R; Neipp, Michael; Mofid, Hamid; Daniels, Thies; Isbert, Christoph; Fraune, Christoph; Möller, Katharina; Menz, Anne; Bernreuther, Christian; Lebok, Patrick; Clauditz, Till; Sauter, Guido; Uhlig, Ria; Wilczak, Waldemar; Simon, Ronald; Steurer, Stefan; Burandt, Eike; Marx, Andreas; Krech, Till.

In: INT J IMMUNOPATH PH, Vol. 36, 3946320221106504, 29.06.2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Dwertmann Rico, S, Büscheck, F, Dum, D, Luebke, AM, Kluth, M, Hube-Magg, C, Hinsch, A, Höflmayer, D, Perez, D, Izbicki, JR, Neipp, M, Mofid, H, Daniels, T, Isbert, C, Fraune, C, Möller, K, Menz, A, Bernreuther, C, Lebok, P, Clauditz, T, Sauter, G, Uhlig, R, Wilczak, W, Simon, R, Steurer, S, Burandt, E, Marx, A & Krech, T 2022, 'Mucin 5AC expression is common but unrelated to tumor progression in pancreatic adenocarcinoma', INT J IMMUNOPATH PH, vol. 36, 3946320221106504. https://doi.org/10.1177/03946320221106504

APA

Dwertmann Rico, S., Büscheck, F., Dum, D., Luebke, A. M., Kluth, M., Hube-Magg, C., Hinsch, A., Höflmayer, D., Perez, D., Izbicki, J. R., Neipp, M., Mofid, H., Daniels, T., Isbert, C., Fraune, C., Möller, K., Menz, A., Bernreuther, C., Lebok, P., ... Krech, T. (2022). Mucin 5AC expression is common but unrelated to tumor progression in pancreatic adenocarcinoma. INT J IMMUNOPATH PH, 36, [3946320221106504]. https://doi.org/10.1177/03946320221106504

Vancouver

Dwertmann Rico S, Büscheck F, Dum D, Luebke AM, Kluth M, Hube-Magg C et al. Mucin 5AC expression is common but unrelated to tumor progression in pancreatic adenocarcinoma. INT J IMMUNOPATH PH. 2022 Jun 29;36. 3946320221106504. https://doi.org/10.1177/03946320221106504

Bibtex

@article{f88be161adff462da4c3e89d4302990e,
title = "Mucin 5AC expression is common but unrelated to tumor progression in pancreatic adenocarcinoma",
abstract = "Introduction: Mucin 5AC (MUC5AC) belongs to the family of secreted gel-forming mucins. It is physiologically expressed in some normal mucin producing epithelial cells but also in pancreatic, ovarian, and colon cancer cells. The role of MUC5AC expression in cancer is not fully understood. This study was designed to explore the role of MUC5AC for pancreatic cancer progression, its association to microsatellite instability, and its diagnostic utility. Methods: Mucin 5AC expression was studied immunohistochemically in a tissue microarray (TMA) from 532 pancreatic cancers, 61 cancers of the ampulla Vateri, six acinar cell carcinomas and 12 large sections of pancreatitis. Results: Mucin 5AC staining was interpretable in 476 of 599 (79%) arrayed cancers. Staining was completely absent in normal pancreas and pancreatitis, but frequent in pancreatic cancer. Membranous and cytoplasmic MUC5AC expression was most common in pancreatic adenocarcinomas (71% of 423), followed by carcinomas of the ampulla Vateri (43% of 47), and absent in six acinar cell carcinomas. Mucin 5AC expression was unrelated to tumor phenotype (tumor stage, tumor grade, lymph node, and distant metastasis), and microsatellite instability in ductal adenocarcinomas and carcinomas of the ampulla Vateri. Conclusion: Our study indicates that MUC5AC is an excellent biomarker for pancreatic cancer diagnosis, especially to support the sometimes-difficult diagnosis on small biopsies. Mucin 5AC expression is unrelated to pancreatic cancer aggressiveness.",
keywords = "Carcinoma, Acinar Cell, Humans, Microsatellite Instability, Mucin 5AC, Pancreatic Neoplasms/diagnosis, Pancreatitis",
author = "{Dwertmann Rico}, Sebastian and Franziska B{\"u}scheck and David Dum and Luebke, {Andreas M} and Martina Kluth and Claudia Hube-Magg and Andrea Hinsch and Doris H{\"o}flmayer and Daniel Perez and Izbicki, {Jakob R} and Michael Neipp and Hamid Mofid and Thies Daniels and Christoph Isbert and Christoph Fraune and Katharina M{\"o}ller and Anne Menz and Christian Bernreuther and Patrick Lebok and Till Clauditz and Guido Sauter and Ria Uhlig and Waldemar Wilczak and Ronald Simon and Stefan Steurer and Eike Burandt and Andreas Marx and Till Krech",
year = "2022",
month = jun,
day = "29",
doi = "10.1177/03946320221106504",
language = "English",
volume = "36",

}

RIS

TY - JOUR

T1 - Mucin 5AC expression is common but unrelated to tumor progression in pancreatic adenocarcinoma

AU - Dwertmann Rico, Sebastian

AU - Büscheck, Franziska

AU - Dum, David

AU - Luebke, Andreas M

AU - Kluth, Martina

AU - Hube-Magg, Claudia

AU - Hinsch, Andrea

AU - Höflmayer, Doris

AU - Perez, Daniel

AU - Izbicki, Jakob R

AU - Neipp, Michael

AU - Mofid, Hamid

AU - Daniels, Thies

AU - Isbert, Christoph

AU - Fraune, Christoph

AU - Möller, Katharina

AU - Menz, Anne

AU - Bernreuther, Christian

AU - Lebok, Patrick

AU - Clauditz, Till

AU - Sauter, Guido

AU - Uhlig, Ria

AU - Wilczak, Waldemar

AU - Simon, Ronald

AU - Steurer, Stefan

AU - Burandt, Eike

AU - Marx, Andreas

AU - Krech, Till

PY - 2022/6/29

Y1 - 2022/6/29

N2 - Introduction: Mucin 5AC (MUC5AC) belongs to the family of secreted gel-forming mucins. It is physiologically expressed in some normal mucin producing epithelial cells but also in pancreatic, ovarian, and colon cancer cells. The role of MUC5AC expression in cancer is not fully understood. This study was designed to explore the role of MUC5AC for pancreatic cancer progression, its association to microsatellite instability, and its diagnostic utility. Methods: Mucin 5AC expression was studied immunohistochemically in a tissue microarray (TMA) from 532 pancreatic cancers, 61 cancers of the ampulla Vateri, six acinar cell carcinomas and 12 large sections of pancreatitis. Results: Mucin 5AC staining was interpretable in 476 of 599 (79%) arrayed cancers. Staining was completely absent in normal pancreas and pancreatitis, but frequent in pancreatic cancer. Membranous and cytoplasmic MUC5AC expression was most common in pancreatic adenocarcinomas (71% of 423), followed by carcinomas of the ampulla Vateri (43% of 47), and absent in six acinar cell carcinomas. Mucin 5AC expression was unrelated to tumor phenotype (tumor stage, tumor grade, lymph node, and distant metastasis), and microsatellite instability in ductal adenocarcinomas and carcinomas of the ampulla Vateri. Conclusion: Our study indicates that MUC5AC is an excellent biomarker for pancreatic cancer diagnosis, especially to support the sometimes-difficult diagnosis on small biopsies. Mucin 5AC expression is unrelated to pancreatic cancer aggressiveness.

AB - Introduction: Mucin 5AC (MUC5AC) belongs to the family of secreted gel-forming mucins. It is physiologically expressed in some normal mucin producing epithelial cells but also in pancreatic, ovarian, and colon cancer cells. The role of MUC5AC expression in cancer is not fully understood. This study was designed to explore the role of MUC5AC for pancreatic cancer progression, its association to microsatellite instability, and its diagnostic utility. Methods: Mucin 5AC expression was studied immunohistochemically in a tissue microarray (TMA) from 532 pancreatic cancers, 61 cancers of the ampulla Vateri, six acinar cell carcinomas and 12 large sections of pancreatitis. Results: Mucin 5AC staining was interpretable in 476 of 599 (79%) arrayed cancers. Staining was completely absent in normal pancreas and pancreatitis, but frequent in pancreatic cancer. Membranous and cytoplasmic MUC5AC expression was most common in pancreatic adenocarcinomas (71% of 423), followed by carcinomas of the ampulla Vateri (43% of 47), and absent in six acinar cell carcinomas. Mucin 5AC expression was unrelated to tumor phenotype (tumor stage, tumor grade, lymph node, and distant metastasis), and microsatellite instability in ductal adenocarcinomas and carcinomas of the ampulla Vateri. Conclusion: Our study indicates that MUC5AC is an excellent biomarker for pancreatic cancer diagnosis, especially to support the sometimes-difficult diagnosis on small biopsies. Mucin 5AC expression is unrelated to pancreatic cancer aggressiveness.

KW - Carcinoma, Acinar Cell

KW - Humans

KW - Microsatellite Instability

KW - Mucin 5AC

KW - Pancreatic Neoplasms/diagnosis

KW - Pancreatitis

U2 - 10.1177/03946320221106504

DO - 10.1177/03946320221106504

M3 - SCORING: Journal article

C2 - 35764407

VL - 36

M1 - 3946320221106504

ER -