Research ExplorerPublicationsMUC5AC Expression in Various Tumor Types and Nonneoplastic T...

MUC5AC Expression in Various Tumor Types and Nonneoplastic Tissue: A Tissue Microarray Study on 10 399 Tissue Samples

Standard

MUC5AC Expression in Various Tumor Types and Nonneoplastic Tissue: A Tissue Microarray Study on 10 399 Tissue Samples. / Rico, Sebastian Dwertmann; Mahnken, Moritz; Büscheck, Franziska; Dum, David; Luebke, Andreas M; Kluth, Martina; Hube-Magg, Claudia; Hinsch, Andrea; Höflmayer, Doris; Möller-Koop, Christina; Fraune, Christoph; Möller, Katharina; Menz, Anne; Bernreuther, Christian; Jacobsen, Frank; Lebok, Patrick; Clauditz, Till S; Sauter, Guido; Uhlig, Ria; Wilczak, Waldemar; Simon, Ronald; Steurer, Stefan; Minner, Sarah; Burandt, Eike; Krech, Till; Marx, Andreas H.

In: TECHNOL CANCER RES T, Vol. 20, 15330338211043328, 23.09.2021.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rico, SD, Mahnken, M, Büscheck, F, Dum, D, Luebke, AM, Kluth, M, Hube-Magg, C, Hinsch, A, Höflmayer, D, Möller-Koop, C, Fraune, C, Möller, K, Menz, A, Bernreuther, C, Jacobsen, F, Lebok, P, Clauditz, TS, Sauter, G, Uhlig, R, Wilczak, W, Simon, R, Steurer, S, Minner, S, Burandt, E, Krech, T & Marx, AH 2021, 'MUC5AC Expression in Various Tumor Types and Nonneoplastic Tissue: A Tissue Microarray Study on 10 399 Tissue Samples', TECHNOL CANCER RES T, vol. 20, 15330338211043328. https://doi.org/10.1177/15330338211043328

APA

Rico, S. D., Mahnken, M., Büscheck, F., Dum, D., Luebke, A. M., Kluth, M., Hube-Magg, C., Hinsch, A., Höflmayer, D., Möller-Koop, C., Fraune, C., Möller, K., Menz, A., Bernreuther, C., Jacobsen, F., Lebok, P., Clauditz, T. S., Sauter, G., Uhlig, R., ... Marx, A. H. (2021). MUC5AC Expression in Various Tumor Types and Nonneoplastic Tissue: A Tissue Microarray Study on 10 399 Tissue Samples. TECHNOL CANCER RES T, 20, [15330338211043328]. https://doi.org/10.1177/15330338211043328

Vancouver

Rico SD, Mahnken M, Büscheck F, Dum D, Luebke AM, Kluth M et al. MUC5AC Expression in Various Tumor Types and Nonneoplastic Tissue: A Tissue Microarray Study on 10 399 Tissue Samples. TECHNOL CANCER RES T. 2021 Sep 23;20. 15330338211043328. https://doi.org/10.1177/15330338211043328

Bibtex

@article{4ee1f77b4ad1401db08be3bcaa393f24,
title = "MUC5AC Expression in Various Tumor Types and Nonneoplastic Tissue: A Tissue Microarray Study on 10 399 Tissue Samples",
abstract = "Background: Mucin 5AC (MUC5AC) belongs to the glycoprotein family of secreted gel-forming mucins and is physiologically expressed in some epithelial cells. Studies have shown that MUC5AC is also expressed in several cancer types suggesting a potential utility for the distinction of tumor types and subtypes. Methods: To systematically determine MUC5AC expression in normal and cancerous tissues, a tissue microarray containing 10 399 samples from 111 different tumor types and subtypes as well as 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. Results: MUC5AC was expressed in normal mucus-producing cells of various organs. At least weak MUC5AC positivity was seen in 44 of 111 (40%) tumor entities. Of these 44 tumor entities, 28 included also tumors with strong positivity. MUC5AC immunostaining was most commonly seen in esophageal adenocarcinoma (72%), colon adenoma (62%), ductal adenocarcinoma of the pancreas (64%), mucinous carcinoma of the ovary (46%), diffuse gastric adenocarcinoma (44%), pancreatic ampullary adenocarcinoma (41%), intestinal gastric adenocarcinoma (39%), and bronchioloalveolar carcinoma (33%). Clinically relevant tumors with complete or almost complete absence of MUC5AC staining included small cell carcinoma of the lung (0% of 17), clear cell renal cell carcinoma (0% of 507), papillary thyroid carcinoma (0% of 359), breast cancer (2% of 1097), prostate cancer (2% of 228), soft tissue tumors (0.1% of 968), and hematological neoplasias (0% of 111). Conclusion: The highly standardized analysis of a broad range of cancers identified a ranking order of tumors according to their relative prevalence of MUC5AC expression.",
author = "Rico, {Sebastian Dwertmann} and Moritz Mahnken and Franziska B{\"u}scheck and David Dum and Luebke, {Andreas M} and Martina Kluth and Claudia Hube-Magg and Andrea Hinsch and Doris H{\"o}flmayer and Christina M{\"o}ller-Koop and Christoph Fraune and Katharina M{\"o}ller and Anne Menz and Christian Bernreuther and Frank Jacobsen and Patrick Lebok and Clauditz, {Till S} and Guido Sauter and Ria Uhlig and Waldemar Wilczak and Ronald Simon and Stefan Steurer and Sarah Minner and Eike Burandt and Till Krech and Marx, {Andreas H}",
year = "2021",
month = sep,
day = "23",
doi = "10.1177/15330338211043328",
language = "English",
volume = "20",
journal = "TECHNOL CANCER RES T",
issn = "1533-0346",
publisher = "Adenine Press",

}

RIS

TY - JOUR

T1 - MUC5AC Expression in Various Tumor Types and Nonneoplastic Tissue: A Tissue Microarray Study on 10 399 Tissue Samples

AU - Rico, Sebastian Dwertmann

AU - Mahnken, Moritz

AU - Büscheck, Franziska

AU - Dum, David

AU - Luebke, Andreas M

AU - Kluth, Martina

AU - Hube-Magg, Claudia

AU - Hinsch, Andrea

AU - Höflmayer, Doris

AU - Möller-Koop, Christina

AU - Fraune, Christoph

AU - Möller, Katharina

AU - Menz, Anne

AU - Bernreuther, Christian

AU - Jacobsen, Frank

AU - Lebok, Patrick

AU - Clauditz, Till S

AU - Sauter, Guido

AU - Uhlig, Ria

AU - Wilczak, Waldemar

AU - Simon, Ronald

AU - Steurer, Stefan

AU - Minner, Sarah

AU - Burandt, Eike

AU - Krech, Till

AU - Marx, Andreas H

PY - 2021/9/23

Y1 - 2021/9/23

N2 - Background: Mucin 5AC (MUC5AC) belongs to the glycoprotein family of secreted gel-forming mucins and is physiologically expressed in some epithelial cells. Studies have shown that MUC5AC is also expressed in several cancer types suggesting a potential utility for the distinction of tumor types and subtypes. Methods: To systematically determine MUC5AC expression in normal and cancerous tissues, a tissue microarray containing 10 399 samples from 111 different tumor types and subtypes as well as 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. Results: MUC5AC was expressed in normal mucus-producing cells of various organs. At least weak MUC5AC positivity was seen in 44 of 111 (40%) tumor entities. Of these 44 tumor entities, 28 included also tumors with strong positivity. MUC5AC immunostaining was most commonly seen in esophageal adenocarcinoma (72%), colon adenoma (62%), ductal adenocarcinoma of the pancreas (64%), mucinous carcinoma of the ovary (46%), diffuse gastric adenocarcinoma (44%), pancreatic ampullary adenocarcinoma (41%), intestinal gastric adenocarcinoma (39%), and bronchioloalveolar carcinoma (33%). Clinically relevant tumors with complete or almost complete absence of MUC5AC staining included small cell carcinoma of the lung (0% of 17), clear cell renal cell carcinoma (0% of 507), papillary thyroid carcinoma (0% of 359), breast cancer (2% of 1097), prostate cancer (2% of 228), soft tissue tumors (0.1% of 968), and hematological neoplasias (0% of 111). Conclusion: The highly standardized analysis of a broad range of cancers identified a ranking order of tumors according to their relative prevalence of MUC5AC expression.

AB - Background: Mucin 5AC (MUC5AC) belongs to the glycoprotein family of secreted gel-forming mucins and is physiologically expressed in some epithelial cells. Studies have shown that MUC5AC is also expressed in several cancer types suggesting a potential utility for the distinction of tumor types and subtypes. Methods: To systematically determine MUC5AC expression in normal and cancerous tissues, a tissue microarray containing 10 399 samples from 111 different tumor types and subtypes as well as 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. Results: MUC5AC was expressed in normal mucus-producing cells of various organs. At least weak MUC5AC positivity was seen in 44 of 111 (40%) tumor entities. Of these 44 tumor entities, 28 included also tumors with strong positivity. MUC5AC immunostaining was most commonly seen in esophageal adenocarcinoma (72%), colon adenoma (62%), ductal adenocarcinoma of the pancreas (64%), mucinous carcinoma of the ovary (46%), diffuse gastric adenocarcinoma (44%), pancreatic ampullary adenocarcinoma (41%), intestinal gastric adenocarcinoma (39%), and bronchioloalveolar carcinoma (33%). Clinically relevant tumors with complete or almost complete absence of MUC5AC staining included small cell carcinoma of the lung (0% of 17), clear cell renal cell carcinoma (0% of 507), papillary thyroid carcinoma (0% of 359), breast cancer (2% of 1097), prostate cancer (2% of 228), soft tissue tumors (0.1% of 968), and hematological neoplasias (0% of 111). Conclusion: The highly standardized analysis of a broad range of cancers identified a ranking order of tumors according to their relative prevalence of MUC5AC expression.

U2 - 10.1177/15330338211043328

DO - 10.1177/15330338211043328

M3 - SCORING: Journal article

C2 - 34547930

VL - 20

JO - TECHNOL CANCER RES T

JF - TECHNOL CANCER RES T

SN - 1533-0346

M1 - 15330338211043328

ER -