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mTOR controls kidney epithelia in health and disease

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mTOR controls kidney epithelia in health and disease. / Grahammer, Florian; Wanner, Nicola; Huber, Tobias B.

In: NEPHROL DIAL TRANSPL, Vol. 29 Suppl 1, 02.2014, p. i9-i18.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Grahammer, F, Wanner, N & Huber, TB 2014, 'mTOR controls kidney epithelia in health and disease', NEPHROL DIAL TRANSPL, vol. 29 Suppl 1, pp. i9-i18. https://doi.org/10.1093/ndt/gft491

APA

Grahammer, F., Wanner, N., & Huber, T. B. (2014). mTOR controls kidney epithelia in health and disease. NEPHROL DIAL TRANSPL, 29 Suppl 1, i9-i18. https://doi.org/10.1093/ndt/gft491

Vancouver

Grahammer F, Wanner N, Huber TB. mTOR controls kidney epithelia in health and disease. NEPHROL DIAL TRANSPL. 2014 Feb;29 Suppl 1:i9-i18. https://doi.org/10.1093/ndt/gft491

Bibtex

@article{ceb9367632a8437b883f526e36566d9f,
title = "mTOR controls kidney epithelia in health and disease",
abstract = "Renal epithelial function is the cornerstone of key excretory processes performed by our kidneys. Most of these tasks need to be tightly controlled to keep our internal environment in balance. Recently, the mTOR signalling network emerged as a key pathway controlling renal epithelial cells from the glomerular tuft along the entire nephron. Both mTOR complexes, mTORC1 and mTORC2, regulate such diverse processes as glomerular filtration and the fine tuning of tubular electrolyte balance. Most importantly, dysregulation of mTOR signalling contributes to prevalent kidney diseases like diabetic nephropathy and cystic kidney disease. The following review shall summarize our current knowledge of the renal epithelial mTOR signalling system under physiological and pathophysiological conditions.",
keywords = "Animals, Epithelial Cells, Humans, Kidney, Kidney Diseases, Kidney Glomerulus, TOR Serine-Threonine Kinases, Journal Article, Research Support, Non-U.S. Gov't, Review",
author = "Florian Grahammer and Nicola Wanner and Huber, {Tobias B}",
year = "2014",
month = feb,
doi = "10.1093/ndt/gft491",
language = "English",
volume = "29 Suppl 1",
pages = "i9--i18",
journal = "NEPHROL DIAL TRANSPL",
issn = "0931-0509",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - mTOR controls kidney epithelia in health and disease

AU - Grahammer, Florian

AU - Wanner, Nicola

AU - Huber, Tobias B

PY - 2014/2

Y1 - 2014/2

N2 - Renal epithelial function is the cornerstone of key excretory processes performed by our kidneys. Most of these tasks need to be tightly controlled to keep our internal environment in balance. Recently, the mTOR signalling network emerged as a key pathway controlling renal epithelial cells from the glomerular tuft along the entire nephron. Both mTOR complexes, mTORC1 and mTORC2, regulate such diverse processes as glomerular filtration and the fine tuning of tubular electrolyte balance. Most importantly, dysregulation of mTOR signalling contributes to prevalent kidney diseases like diabetic nephropathy and cystic kidney disease. The following review shall summarize our current knowledge of the renal epithelial mTOR signalling system under physiological and pathophysiological conditions.

AB - Renal epithelial function is the cornerstone of key excretory processes performed by our kidneys. Most of these tasks need to be tightly controlled to keep our internal environment in balance. Recently, the mTOR signalling network emerged as a key pathway controlling renal epithelial cells from the glomerular tuft along the entire nephron. Both mTOR complexes, mTORC1 and mTORC2, regulate such diverse processes as glomerular filtration and the fine tuning of tubular electrolyte balance. Most importantly, dysregulation of mTOR signalling contributes to prevalent kidney diseases like diabetic nephropathy and cystic kidney disease. The following review shall summarize our current knowledge of the renal epithelial mTOR signalling system under physiological and pathophysiological conditions.

KW - Animals

KW - Epithelial Cells

KW - Humans

KW - Kidney

KW - Kidney Diseases

KW - Kidney Glomerulus

KW - TOR Serine-Threonine Kinases

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1093/ndt/gft491

DO - 10.1093/ndt/gft491

M3 - SCORING: Review article

C2 - 24493874

VL - 29 Suppl 1

SP - i9-i18

JO - NEPHROL DIAL TRANSPL

JF - NEPHROL DIAL TRANSPL

SN - 0931-0509

ER -