MSH2 deficient mice are viable and susceptible to lymphoid tumours
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MSH2 deficient mice are viable and susceptible to lymphoid tumours. / Reitmair, A H; Schmits, R; Ewel, A; Bapat, B; Redston, M; Mitri, A; Waterhouse, P; Mittrücker, H W; Wakeham, A; Liu, B.
In: NAT GENET, Vol. 11, No. 1, 01.09.1995, p. 64-70.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - MSH2 deficient mice are viable and susceptible to lymphoid tumours
AU - Reitmair, A H
AU - Schmits, R
AU - Ewel, A
AU - Bapat, B
AU - Redston, M
AU - Mitri, A
AU - Waterhouse, P
AU - Mittrücker, H W
AU - Wakeham, A
AU - Liu, B
PY - 1995/9/1
Y1 - 1995/9/1
N2 - Alterations of the human MSH2 gene, a homologue of the bacterial MutS mismatch repair gene, co-segregate with the majority of hereditary non-polyposis colon cancer (HNPCC) cases. We have generated homozygous MSH2-/- mice. Surprisingly, these mice were found to be viable, produced offspring in a mendelian ratio and bred through at least two generations. Starting at two months of age homozygous-/- mice began, with high frequency, to develop lymphoid tumours that contained microsatellite instabilities. These data establish a direct link between MSH2 deficiency and the pathogenesis of cancer. These mutant mice should be good models to study the progression of tumours and also to screen carcinogenic and anti-cancer agents.
AB - Alterations of the human MSH2 gene, a homologue of the bacterial MutS mismatch repair gene, co-segregate with the majority of hereditary non-polyposis colon cancer (HNPCC) cases. We have generated homozygous MSH2-/- mice. Surprisingly, these mice were found to be viable, produced offspring in a mendelian ratio and bred through at least two generations. Starting at two months of age homozygous-/- mice began, with high frequency, to develop lymphoid tumours that contained microsatellite instabilities. These data establish a direct link between MSH2 deficiency and the pathogenesis of cancer. These mutant mice should be good models to study the progression of tumours and also to screen carcinogenic and anti-cancer agents.
KW - Animals
KW - Base Sequence
KW - Cell Transformation, Neoplastic
KW - Colorectal Neoplasms, Hereditary Nonpolyposis
KW - DNA Repair
KW - DNA, Neoplasm
KW - DNA, Satellite
KW - DNA-Binding Proteins
KW - Female
KW - Fungal Proteins
KW - Gene Targeting
KW - Genotype
KW - Humans
KW - Lymphoid Tissue
KW - Male
KW - Meiosis
KW - Mice
KW - Mice, Knockout
KW - Mice, Mutant Strains
KW - Molecular Sequence Data
KW - MutS Homolog 2 Protein
KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma
KW - Species Specificity
U2 - 10.1038/ng0995-64
DO - 10.1038/ng0995-64
M3 - SCORING: Journal article
C2 - 7550317
VL - 11
SP - 64
EP - 70
JO - NAT GENET
JF - NAT GENET
SN - 1061-4036
IS - 1
ER -