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MRI in acute cerebral ischemia of the Young: the Stroke in Young Fabry Patients (sifap1) Study

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MRI in acute cerebral ischemia of the Young: the Stroke in Young Fabry Patients (sifap1) Study. / Fazekas, Franz; Enzinger, Christian; Schmidt, Reinhold; Dichgans, Martin; Gaertner, Beate; Jungehulsing, Gerhard J; Hennerici, Michael G; Heuschmann, Peter; Holzhausen, Martin; Kaps, Manfred; Kessler, Christof; Martus, Peter; Putaala, Jukka; Ropele, Stefan; Tanislav, Christian; Tatlisumak, Turgut; Norrving, Bo; Rolfs, Arndt; SIFAP 1 Investigators.

In: NEUROLOGY, Vol. 81, No. 22, 26.11.2013, p. 1914-21.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Fazekas, F, Enzinger, C, Schmidt, R, Dichgans, M, Gaertner, B, Jungehulsing, GJ, Hennerici, MG, Heuschmann, P, Holzhausen, M, Kaps, M, Kessler, C, Martus, P, Putaala, J, Ropele, S, Tanislav, C, Tatlisumak, T, Norrving, B, Rolfs, A & SIFAP 1 Investigators 2013, 'MRI in acute cerebral ischemia of the Young: the Stroke in Young Fabry Patients (sifap1) Study', NEUROLOGY, vol. 81, no. 22, pp. 1914-21. https://doi.org/10.1212/01.wnl.0000436611.28210.ec

APA

Fazekas, F., Enzinger, C., Schmidt, R., Dichgans, M., Gaertner, B., Jungehulsing, G. J., Hennerici, M. G., Heuschmann, P., Holzhausen, M., Kaps, M., Kessler, C., Martus, P., Putaala, J., Ropele, S., Tanislav, C., Tatlisumak, T., Norrving, B., Rolfs, A., & SIFAP 1 Investigators (2013). MRI in acute cerebral ischemia of the Young: the Stroke in Young Fabry Patients (sifap1) Study. NEUROLOGY, 81(22), 1914-21. https://doi.org/10.1212/01.wnl.0000436611.28210.ec

Vancouver

Fazekas F, Enzinger C, Schmidt R, Dichgans M, Gaertner B, Jungehulsing GJ et al. MRI in acute cerebral ischemia of the Young: the Stroke in Young Fabry Patients (sifap1) Study. NEUROLOGY. 2013 Nov 26;81(22):1914-21. https://doi.org/10.1212/01.wnl.0000436611.28210.ec

Bibtex

@article{e9e79ab2a7954bf5bb89a5d494f7e588,
title = "MRI in acute cerebral ischemia of the Young: the Stroke in Young Fabry Patients (sifap1) Study",
abstract = "OBJECTIVE: We focused on cerebral imaging findings in a large cohort of young patients with a symptomatic ischemic cerebrovascular event (CVE) to extract relevant pathophysiologic and clinical information.METHODS: We analyzed the scans of 2,979 patients (aged 18-55 years) enrolled in the sifap1 project with clinical evidence of ischemic stroke (IS) or clinically defined TIA in whom MRI, including diffusion-weighted imaging, was obtained within 10 days of the CVE. Age groups were categorized as 18-34, 35-44, and 45-55 years. We compared age- and sex-specific proportions of infarct features, white matter hyperintensities, and old microbleeds.RESULTS: Acute infarcts were identified in 1,914 of 2,264 patients (84.5%) with IS and 101 of 715 patients (14.1%) with TIA. Among patients with IS, younger age was significantly associated with acute infarcts in the posterior circulation, while anterior circulation infarcts and acute lacunar infarcts were more frequent in older age groups. One or more old infarcts were present in 26.8% of IS and 17.1% of TIA patients. This rate remained high even after excluding patients with a prior CVE (IS, 21.7%; TIA, 9.9%). The prevailing type of old infarction was territorial in patients younger than 45 years and lacunar in those aged 45 years or older. The frequency of white matter hyperintensities (46.4%) and their severity was positively associated with age. Old microbleeds were infrequent (7.2%).CONCLUSIONS: Young adults show a high frequency of preexisting and clinically silent infarcts and a relative preference for acute ischemia in the posterior circulation. Findings suggesting small-vessel disease become apparent at age 45 years and older.",
keywords = "Adolescent, Adult, Age Factors, Cerebral Cortex, Cerebral Infarction, Cohort Studies, Europe, Female, Humans, Image Processing, Computer-Assisted, International Cooperation, Ischemic Attack, Transient, Magnetic Resonance Imaging, Male, Middle Aged, Retrospective Studies, Severity of Illness Index, Sex Factors, Stroke, Young Adult",
author = "Franz Fazekas and Christian Enzinger and Reinhold Schmidt and Martin Dichgans and Beate Gaertner and Jungehulsing, {Gerhard J} and Hennerici, {Michael G} and Peter Heuschmann and Martin Holzhausen and Manfred Kaps and Christof Kessler and Peter Martus and Jukka Putaala and Stefan Ropele and Christian Tanislav and Turgut Tatlisumak and Bo Norrving and Arndt Rolfs and {SIFAP 1 Investigators} and G{\"o}tz Thomalla",
year = "2013",
month = nov,
day = "26",
doi = "10.1212/01.wnl.0000436611.28210.ec",
language = "English",
volume = "81",
pages = "1914--21",
journal = "NEUROLOGY",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "22",

}

RIS

TY - JOUR

T1 - MRI in acute cerebral ischemia of the Young: the Stroke in Young Fabry Patients (sifap1) Study

AU - Fazekas, Franz

AU - Enzinger, Christian

AU - Schmidt, Reinhold

AU - Dichgans, Martin

AU - Gaertner, Beate

AU - Jungehulsing, Gerhard J

AU - Hennerici, Michael G

AU - Heuschmann, Peter

AU - Holzhausen, Martin

AU - Kaps, Manfred

AU - Kessler, Christof

AU - Martus, Peter

AU - Putaala, Jukka

AU - Ropele, Stefan

AU - Tanislav, Christian

AU - Tatlisumak, Turgut

AU - Norrving, Bo

AU - Rolfs, Arndt

AU - SIFAP 1 Investigators

AU - Thomalla, Götz

PY - 2013/11/26

Y1 - 2013/11/26

N2 - OBJECTIVE: We focused on cerebral imaging findings in a large cohort of young patients with a symptomatic ischemic cerebrovascular event (CVE) to extract relevant pathophysiologic and clinical information.METHODS: We analyzed the scans of 2,979 patients (aged 18-55 years) enrolled in the sifap1 project with clinical evidence of ischemic stroke (IS) or clinically defined TIA in whom MRI, including diffusion-weighted imaging, was obtained within 10 days of the CVE. Age groups were categorized as 18-34, 35-44, and 45-55 years. We compared age- and sex-specific proportions of infarct features, white matter hyperintensities, and old microbleeds.RESULTS: Acute infarcts were identified in 1,914 of 2,264 patients (84.5%) with IS and 101 of 715 patients (14.1%) with TIA. Among patients with IS, younger age was significantly associated with acute infarcts in the posterior circulation, while anterior circulation infarcts and acute lacunar infarcts were more frequent in older age groups. One or more old infarcts were present in 26.8% of IS and 17.1% of TIA patients. This rate remained high even after excluding patients with a prior CVE (IS, 21.7%; TIA, 9.9%). The prevailing type of old infarction was territorial in patients younger than 45 years and lacunar in those aged 45 years or older. The frequency of white matter hyperintensities (46.4%) and their severity was positively associated with age. Old microbleeds were infrequent (7.2%).CONCLUSIONS: Young adults show a high frequency of preexisting and clinically silent infarcts and a relative preference for acute ischemia in the posterior circulation. Findings suggesting small-vessel disease become apparent at age 45 years and older.

AB - OBJECTIVE: We focused on cerebral imaging findings in a large cohort of young patients with a symptomatic ischemic cerebrovascular event (CVE) to extract relevant pathophysiologic and clinical information.METHODS: We analyzed the scans of 2,979 patients (aged 18-55 years) enrolled in the sifap1 project with clinical evidence of ischemic stroke (IS) or clinically defined TIA in whom MRI, including diffusion-weighted imaging, was obtained within 10 days of the CVE. Age groups were categorized as 18-34, 35-44, and 45-55 years. We compared age- and sex-specific proportions of infarct features, white matter hyperintensities, and old microbleeds.RESULTS: Acute infarcts were identified in 1,914 of 2,264 patients (84.5%) with IS and 101 of 715 patients (14.1%) with TIA. Among patients with IS, younger age was significantly associated with acute infarcts in the posterior circulation, while anterior circulation infarcts and acute lacunar infarcts were more frequent in older age groups. One or more old infarcts were present in 26.8% of IS and 17.1% of TIA patients. This rate remained high even after excluding patients with a prior CVE (IS, 21.7%; TIA, 9.9%). The prevailing type of old infarction was territorial in patients younger than 45 years and lacunar in those aged 45 years or older. The frequency of white matter hyperintensities (46.4%) and their severity was positively associated with age. Old microbleeds were infrequent (7.2%).CONCLUSIONS: Young adults show a high frequency of preexisting and clinically silent infarcts and a relative preference for acute ischemia in the posterior circulation. Findings suggesting small-vessel disease become apparent at age 45 years and older.

KW - Adolescent

KW - Adult

KW - Age Factors

KW - Cerebral Cortex

KW - Cerebral Infarction

KW - Cohort Studies

KW - Europe

KW - Female

KW - Humans

KW - Image Processing, Computer-Assisted

KW - International Cooperation

KW - Ischemic Attack, Transient

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Retrospective Studies

KW - Severity of Illness Index

KW - Sex Factors

KW - Stroke

KW - Young Adult

U2 - 10.1212/01.wnl.0000436611.28210.ec

DO - 10.1212/01.wnl.0000436611.28210.ec

M3 - SCORING: Journal article

C2 - 24186912

VL - 81

SP - 1914

EP - 1921

JO - NEUROLOGY

JF - NEUROLOGY

SN - 0028-3878

IS - 22

ER -