Mouse models in skeletal physiology and osteoporosis: experiences and data on 14,839 cases from the Hamburg Mouse Archives.
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Mouse models in skeletal physiology and osteoporosis: experiences and data on 14,839 cases from the Hamburg Mouse Archives. / Pogoda, Pia; Priemel, Matthias; Schilling, Arndt F; Gebauer, Matthias; Catalá-Lehnen, Philip; Barvencik, Florian; Beil, F Timo; Münch, Christian; Rupprecht, Martin; Müldner, Cordula; Rueger, Johannes M; Schinke, Thorsten; Amling, Michael.
In: J BONE MINER METAB, Vol. 23, 01.01.2005, p. 97-102.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Mouse models in skeletal physiology and osteoporosis: experiences and data on 14,839 cases from the Hamburg Mouse Archives.
AU - Pogoda, Pia
AU - Priemel, Matthias
AU - Schilling, Arndt F
AU - Gebauer, Matthias
AU - Catalá-Lehnen, Philip
AU - Barvencik, Florian
AU - Beil, F Timo
AU - Münch, Christian
AU - Rupprecht, Martin
AU - Müldner, Cordula
AU - Rueger, Johannes M
AU - Schinke, Thorsten
AU - Amling, Michael
PY - 2005/1/1
Y1 - 2005/1/1
N2 - Our understanding of the developmental biology of the skeleton, like that of virtually every other subject in biology, has been transformed by recent advances in human and mouse genetics, but we still know very little, in molecular and genetic terms, about skeletal physiology. Thus, among the many questions that are largely unexplained are the following: why is osteoporosis mainly a women's disease? How is bone mass maintained nearly constant between the end of puberty and the arrest of gonadal functions? Molecular genetics has emerged as a powerful tool to study previously unexplored aspects of the physiology of the skeleton. Among mammals, mice are the most promising animals for this experimental work. The input that transgenic animals can offer to our field depends on our means of phenotypic characterization of the mouse skeleton. In fact, full appreciation of the skeletal characteristics of a given mouse model requires the application of standardized protocols for noninvasive imaging, histology, histomorphometry, biomechanics, and individually adapted in vitro and in vivo analysis. Over the past years we have established a mouse archive that consists of 14,839 cases from more than 120 different mouse models that we have phenotypically characterized in Hamburg. Today, this is one of the biggest databases on the mouse skeleton. This review focuses on one aspect of skeletal physiology, namely skeletal aging, and demonstrates that mouse models can be a valuable tool to gain insights in certain facets of skeletal physiology that have been unexplored previously.
AB - Our understanding of the developmental biology of the skeleton, like that of virtually every other subject in biology, has been transformed by recent advances in human and mouse genetics, but we still know very little, in molecular and genetic terms, about skeletal physiology. Thus, among the many questions that are largely unexplained are the following: why is osteoporosis mainly a women's disease? How is bone mass maintained nearly constant between the end of puberty and the arrest of gonadal functions? Molecular genetics has emerged as a powerful tool to study previously unexplored aspects of the physiology of the skeleton. Among mammals, mice are the most promising animals for this experimental work. The input that transgenic animals can offer to our field depends on our means of phenotypic characterization of the mouse skeleton. In fact, full appreciation of the skeletal characteristics of a given mouse model requires the application of standardized protocols for noninvasive imaging, histology, histomorphometry, biomechanics, and individually adapted in vitro and in vivo analysis. Over the past years we have established a mouse archive that consists of 14,839 cases from more than 120 different mouse models that we have phenotypically characterized in Hamburg. Today, this is one of the biggest databases on the mouse skeleton. This review focuses on one aspect of skeletal physiology, namely skeletal aging, and demonstrates that mouse models can be a valuable tool to gain insights in certain facets of skeletal physiology that have been unexplored previously.
KW - Animals
KW - Bone and Bones
KW - Disease Models, Animal
KW - Female
KW - Male
KW - Mice
KW - Mice, Knockout
KW - Osteoporosis
U2 - 10.1007/BF03026332
DO - 10.1007/BF03026332
M3 - SCORING: Journal article
C2 - 15984423
VL - 23
SP - 97
EP - 102
JO - J BONE MINER METAB
JF - J BONE MINER METAB
SN - 0914-8779
ER -