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Mortality in Incident Cognitive Impairment: Results of the Prospective AgeCoDe Study

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Mortality in Incident Cognitive Impairment: Results of the Prospective AgeCoDe Study. / Luck, Tobias; Riedel-Heller, Steffi G; Roehr, Susanne; Wiese, Birgitt; van der Leeden, Carolin; Heser, Kathrin; Bickel, Horst; Pentzek, Michael; König, Hans-Helmut; Werle, Jochen; Mamone, Silke; Mallon, Tina; Wolfsgruber, Steffen; Weeg, Dagmar; Fuchs, Angela; Brettschneider, Christian; Scherer, Martin; Maier, Wolfgang; Weyerer, Siegfried; AgeCoDe Study Group.

In: J AM GERIATR SOC, Vol. 65, No. 4, 04.2017, p. 738-746.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Luck, T, Riedel-Heller, SG, Roehr, S, Wiese, B, van der Leeden, C, Heser, K, Bickel, H, Pentzek, M, König, H-H, Werle, J, Mamone, S, Mallon, T, Wolfsgruber, S, Weeg, D, Fuchs, A, Brettschneider, C, Scherer, M, Maier, W, Weyerer, S & AgeCoDe Study Group 2017, 'Mortality in Incident Cognitive Impairment: Results of the Prospective AgeCoDe Study', J AM GERIATR SOC, vol. 65, no. 4, pp. 738-746. https://doi.org/10.1111/jgs.14666

APA

Luck, T., Riedel-Heller, S. G., Roehr, S., Wiese, B., van der Leeden, C., Heser, K., Bickel, H., Pentzek, M., König, H-H., Werle, J., Mamone, S., Mallon, T., Wolfsgruber, S., Weeg, D., Fuchs, A., Brettschneider, C., Scherer, M., Maier, W., Weyerer, S., & AgeCoDe Study Group (2017). Mortality in Incident Cognitive Impairment: Results of the Prospective AgeCoDe Study. J AM GERIATR SOC, 65(4), 738-746. https://doi.org/10.1111/jgs.14666

Vancouver

Luck T, Riedel-Heller SG, Roehr S, Wiese B, van der Leeden C, Heser K et al. Mortality in Incident Cognitive Impairment: Results of the Prospective AgeCoDe Study. J AM GERIATR SOC. 2017 Apr;65(4):738-746. https://doi.org/10.1111/jgs.14666

Bibtex

@article{add15a0082f5481789961553017fe63b,
title = "Mortality in Incident Cognitive Impairment: Results of the Prospective AgeCoDe Study",
abstract = "OBJECTIVES: To investigate mortality risk and survival time in new-incident cases of cognitive impairment (CI) in old age.DESIGN: Prospective cohort study in six German cities.SETTING: German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe).PARTICIPANTS: Two thousand eighty-nine nondemented GP patients aged 75+.MEASUREMENTS: Every 18 months, trained psychologists and physicians conducted structured clinical interviews at the participants' homes. Dates of death were obtained from relatives, general practitioner (GP), or the local registry offices. We used the Kaplan-Meier survival method to estimate survival times of individuals with and without incident CI and multivariable Cox proportional hazards regressions to assess the association between CI and mortality risk, controlled for covariates.RESULTS: Out of the 2,089 included patients at follow-up I, 859 (41.1%) died during the subsequent mean observation period of 8.0 years. Patients with incident CI at follow-up I showed a significantly higher case-fatality rate per 1,000 person-years (74.2, 95% CI = 64.2-84.2 vs 47.8, 95% CI = 44.6-51.0) and a significantly shorter mean survival time in the observation period than those without (7.8 vs 9.1 years; P < .001). The association between incident CI and mortality remained significant in the multivariable Cox analyses-incident CI was associated with a 42% increased, incident severe CI with a 75% increased mortality risk.CONCLUSION: Our findings suggest an elevated mortality risk in newly acquired cognitive deficits in old age. Even though further studies are required to analyze potential underlying mechanisms, our findings support the notion that such cognitive deficits should be taken seriously in clinical practice not only for an increased risk of developing dementia but also for a broader range of possible adverse health outcomes.",
author = "Tobias Luck and Riedel-Heller, {Steffi G} and Susanne Roehr and Birgitt Wiese and {van der Leeden}, Carolin and Kathrin Heser and Horst Bickel and Michael Pentzek and Hans-Helmut K{\"o}nig and Jochen Werle and Silke Mamone and Tina Mallon and Steffen Wolfsgruber and Dagmar Weeg and Angela Fuchs and Christian Brettschneider and Martin Scherer and Wolfgang Maier and Siegfried Weyerer and {AgeCoDe Study Group}",
note = "{\textcopyright} 2016, Copyright the Authors Journal compilation {\textcopyright} 2016, The American Geriatrics Society.",
year = "2017",
month = apr,
doi = "10.1111/jgs.14666",
language = "English",
volume = "65",
pages = "738--746",
journal = "J AM GERIATR SOC",
issn = "0002-8614",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Mortality in Incident Cognitive Impairment: Results of the Prospective AgeCoDe Study

AU - Luck, Tobias

AU - Riedel-Heller, Steffi G

AU - Roehr, Susanne

AU - Wiese, Birgitt

AU - van der Leeden, Carolin

AU - Heser, Kathrin

AU - Bickel, Horst

AU - Pentzek, Michael

AU - König, Hans-Helmut

AU - Werle, Jochen

AU - Mamone, Silke

AU - Mallon, Tina

AU - Wolfsgruber, Steffen

AU - Weeg, Dagmar

AU - Fuchs, Angela

AU - Brettschneider, Christian

AU - Scherer, Martin

AU - Maier, Wolfgang

AU - Weyerer, Siegfried

AU - AgeCoDe Study Group

N1 - © 2016, Copyright the Authors Journal compilation © 2016, The American Geriatrics Society.

PY - 2017/4

Y1 - 2017/4

N2 - OBJECTIVES: To investigate mortality risk and survival time in new-incident cases of cognitive impairment (CI) in old age.DESIGN: Prospective cohort study in six German cities.SETTING: German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe).PARTICIPANTS: Two thousand eighty-nine nondemented GP patients aged 75+.MEASUREMENTS: Every 18 months, trained psychologists and physicians conducted structured clinical interviews at the participants' homes. Dates of death were obtained from relatives, general practitioner (GP), or the local registry offices. We used the Kaplan-Meier survival method to estimate survival times of individuals with and without incident CI and multivariable Cox proportional hazards regressions to assess the association between CI and mortality risk, controlled for covariates.RESULTS: Out of the 2,089 included patients at follow-up I, 859 (41.1%) died during the subsequent mean observation period of 8.0 years. Patients with incident CI at follow-up I showed a significantly higher case-fatality rate per 1,000 person-years (74.2, 95% CI = 64.2-84.2 vs 47.8, 95% CI = 44.6-51.0) and a significantly shorter mean survival time in the observation period than those without (7.8 vs 9.1 years; P < .001). The association between incident CI and mortality remained significant in the multivariable Cox analyses-incident CI was associated with a 42% increased, incident severe CI with a 75% increased mortality risk.CONCLUSION: Our findings suggest an elevated mortality risk in newly acquired cognitive deficits in old age. Even though further studies are required to analyze potential underlying mechanisms, our findings support the notion that such cognitive deficits should be taken seriously in clinical practice not only for an increased risk of developing dementia but also for a broader range of possible adverse health outcomes.

AB - OBJECTIVES: To investigate mortality risk and survival time in new-incident cases of cognitive impairment (CI) in old age.DESIGN: Prospective cohort study in six German cities.SETTING: German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe).PARTICIPANTS: Two thousand eighty-nine nondemented GP patients aged 75+.MEASUREMENTS: Every 18 months, trained psychologists and physicians conducted structured clinical interviews at the participants' homes. Dates of death were obtained from relatives, general practitioner (GP), or the local registry offices. We used the Kaplan-Meier survival method to estimate survival times of individuals with and without incident CI and multivariable Cox proportional hazards regressions to assess the association between CI and mortality risk, controlled for covariates.RESULTS: Out of the 2,089 included patients at follow-up I, 859 (41.1%) died during the subsequent mean observation period of 8.0 years. Patients with incident CI at follow-up I showed a significantly higher case-fatality rate per 1,000 person-years (74.2, 95% CI = 64.2-84.2 vs 47.8, 95% CI = 44.6-51.0) and a significantly shorter mean survival time in the observation period than those without (7.8 vs 9.1 years; P < .001). The association between incident CI and mortality remained significant in the multivariable Cox analyses-incident CI was associated with a 42% increased, incident severe CI with a 75% increased mortality risk.CONCLUSION: Our findings suggest an elevated mortality risk in newly acquired cognitive deficits in old age. Even though further studies are required to analyze potential underlying mechanisms, our findings support the notion that such cognitive deficits should be taken seriously in clinical practice not only for an increased risk of developing dementia but also for a broader range of possible adverse health outcomes.

U2 - 10.1111/jgs.14666

DO - 10.1111/jgs.14666

M3 - SCORING: Journal article

C2 - 27991650

VL - 65

SP - 738

EP - 746

JO - J AM GERIATR SOC

JF - J AM GERIATR SOC

SN - 0002-8614

IS - 4

ER -