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Mortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations.

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Mortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations. / Friedrich, Nele; Haring, Robin; Nauck, Matthias; Lüdemann, Jan; Rosskopf, Dieter; Spilcke-Liss, Elisabeth; Felix, Stephan B; Dörr, Marcus; Brabant, Georg; Völzke, Henry; Wallaschofski, Henri.

In: J CLIN ENDOCR METAB, Vol. 94, No. 5, 5, 2009, p. 1732-1739.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Friedrich, N, Haring, R, Nauck, M, Lüdemann, J, Rosskopf, D, Spilcke-Liss, E, Felix, SB, Dörr, M, Brabant, G, Völzke, H & Wallaschofski, H 2009, 'Mortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations.', J CLIN ENDOCR METAB, vol. 94, no. 5, 5, pp. 1732-1739. <http://www.ncbi.nlm.nih.gov/pubmed/19223521?dopt=Citation>

APA

Friedrich, N., Haring, R., Nauck, M., Lüdemann, J., Rosskopf, D., Spilcke-Liss, E., Felix, S. B., Dörr, M., Brabant, G., Völzke, H., & Wallaschofski, H. (2009). Mortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations. J CLIN ENDOCR METAB, 94(5), 1732-1739. [5]. http://www.ncbi.nlm.nih.gov/pubmed/19223521?dopt=Citation

Vancouver

Friedrich N, Haring R, Nauck M, Lüdemann J, Rosskopf D, Spilcke-Liss E et al. Mortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations. J CLIN ENDOCR METAB. 2009;94(5):1732-1739. 5.

Bibtex

@article{8df352b701f0407d9b1aa9ee40135466,
title = "Mortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations.",
abstract = "BACKGROUND: Previous studies provided conflicting results regarding the association of serum IGF-I or IGF-binding protein-3 (IGFBP-3) and mortality. The aim of this study was to assess the relation of IGF-I and IGFBP-3 levels with mortality from all causes, cardiovascular disease (CVD), and cancer in a prospective population-based study. METHODS: From the Study of Health in Pomerania (SHIP) 1988 men and 2069 women aged 20-79 yr were followed up on average 8.5 yr. Causes of deaths were coded according to the International Classification of Diseases, 10th revision. Serum IGF-I and IGFBP-3 levels were determined by chemiluminescence immunoassays and categorized into three groups (low, normal, high) according to the sex- and age-specific 10th and 90th percentiles. RESULTS: Adjusted analyses revealed that men with low but not high IGF-I levels had an almost 2-fold higher risk of all-cause mortality [hazard ratio (HR) 1.92 (95% confidence interval [CI] 1.35; 2.73)], CVD mortality [HR 1.92 (95% CI 1.00; 3.71)], and cancer mortality [HR 1.85 (95% CI 1.00; 3.45)] compared with men with normal IGF-I levels. In women, no association between IGF-I and mortality was found. Moreover, low IGFBP-3 levels were associated with higher all-cause mortality in men [HR 1.87 (95% CI 1.31; 2.64)] and women [HR 1.63 (95% CI 0.96; 2.76)]. CONCLUSIONS: The present study found inverse associations between IGF-I or IGFBP-3 levels and mortality from all causes, CVD, or cancer in men and between IGFBP-3 and all-cause mortality in women.",
author = "Nele Friedrich and Robin Haring and Matthias Nauck and Jan L{\"u}demann and Dieter Rosskopf and Elisabeth Spilcke-Liss and Felix, {Stephan B} and Marcus D{\"o}rr and Georg Brabant and Henry V{\"o}lzke and Henri Wallaschofski",
year = "2009",
language = "Deutsch",
volume = "94",
pages = "1732--1739",
journal = "J CLIN ENDOCR METAB",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "5",

}

RIS

TY - JOUR

T1 - Mortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations.

AU - Friedrich, Nele

AU - Haring, Robin

AU - Nauck, Matthias

AU - Lüdemann, Jan

AU - Rosskopf, Dieter

AU - Spilcke-Liss, Elisabeth

AU - Felix, Stephan B

AU - Dörr, Marcus

AU - Brabant, Georg

AU - Völzke, Henry

AU - Wallaschofski, Henri

PY - 2009

Y1 - 2009

N2 - BACKGROUND: Previous studies provided conflicting results regarding the association of serum IGF-I or IGF-binding protein-3 (IGFBP-3) and mortality. The aim of this study was to assess the relation of IGF-I and IGFBP-3 levels with mortality from all causes, cardiovascular disease (CVD), and cancer in a prospective population-based study. METHODS: From the Study of Health in Pomerania (SHIP) 1988 men and 2069 women aged 20-79 yr were followed up on average 8.5 yr. Causes of deaths were coded according to the International Classification of Diseases, 10th revision. Serum IGF-I and IGFBP-3 levels were determined by chemiluminescence immunoassays and categorized into three groups (low, normal, high) according to the sex- and age-specific 10th and 90th percentiles. RESULTS: Adjusted analyses revealed that men with low but not high IGF-I levels had an almost 2-fold higher risk of all-cause mortality [hazard ratio (HR) 1.92 (95% confidence interval [CI] 1.35; 2.73)], CVD mortality [HR 1.92 (95% CI 1.00; 3.71)], and cancer mortality [HR 1.85 (95% CI 1.00; 3.45)] compared with men with normal IGF-I levels. In women, no association between IGF-I and mortality was found. Moreover, low IGFBP-3 levels were associated with higher all-cause mortality in men [HR 1.87 (95% CI 1.31; 2.64)] and women [HR 1.63 (95% CI 0.96; 2.76)]. CONCLUSIONS: The present study found inverse associations between IGF-I or IGFBP-3 levels and mortality from all causes, CVD, or cancer in men and between IGFBP-3 and all-cause mortality in women.

AB - BACKGROUND: Previous studies provided conflicting results regarding the association of serum IGF-I or IGF-binding protein-3 (IGFBP-3) and mortality. The aim of this study was to assess the relation of IGF-I and IGFBP-3 levels with mortality from all causes, cardiovascular disease (CVD), and cancer in a prospective population-based study. METHODS: From the Study of Health in Pomerania (SHIP) 1988 men and 2069 women aged 20-79 yr were followed up on average 8.5 yr. Causes of deaths were coded according to the International Classification of Diseases, 10th revision. Serum IGF-I and IGFBP-3 levels were determined by chemiluminescence immunoassays and categorized into three groups (low, normal, high) according to the sex- and age-specific 10th and 90th percentiles. RESULTS: Adjusted analyses revealed that men with low but not high IGF-I levels had an almost 2-fold higher risk of all-cause mortality [hazard ratio (HR) 1.92 (95% confidence interval [CI] 1.35; 2.73)], CVD mortality [HR 1.92 (95% CI 1.00; 3.71)], and cancer mortality [HR 1.85 (95% CI 1.00; 3.45)] compared with men with normal IGF-I levels. In women, no association between IGF-I and mortality was found. Moreover, low IGFBP-3 levels were associated with higher all-cause mortality in men [HR 1.87 (95% CI 1.31; 2.64)] and women [HR 1.63 (95% CI 0.96; 2.76)]. CONCLUSIONS: The present study found inverse associations between IGF-I or IGFBP-3 levels and mortality from all causes, CVD, or cancer in men and between IGFBP-3 and all-cause mortality in women.

M3 - SCORING: Zeitschriftenaufsatz

VL - 94

SP - 1732

EP - 1739

JO - J CLIN ENDOCR METAB

JF - J CLIN ENDOCR METAB

SN - 0021-972X

IS - 5

M1 - 5

ER -