Morphogenic signaling in neurons via neurotransmitter receptors and small GTPases.
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Morphogenic signaling in neurons via neurotransmitter receptors and small GTPases. / Ponimaskin, Evgeni; Voyno-Yasenetskaya, Tatyana; Richter, Diethelm W; Schachner, Melitta; Dityatev, Alexander.
In: MOL NEUROBIOL, Vol. 35, No. 3, 3, 2007, p. 278-287.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Morphogenic signaling in neurons via neurotransmitter receptors and small GTPases.
AU - Ponimaskin, Evgeni
AU - Voyno-Yasenetskaya, Tatyana
AU - Richter, Diethelm W
AU - Schachner, Melitta
AU - Dityatev, Alexander
PY - 2007
Y1 - 2007
N2 - Several neurotransmitters including serotonin and glutamate have been shown to be involved in many aspects of neural development, such as neurite outgrowth, regulation of neuronal morphology, growth cone motility and dendritic spine shape and density, in addition to their well-established role in neuronal communication. This review focuses on recent advances in our understanding of the molecular mechanisms underlying neurotransmitter-induced changes in neuronal morphology. In the first part of the review, we introduce the roles of small GTPases of the Rho family in morphogenic signaling in neurons and discuss signaling pathways, which may link serotonin, operating as a soluble guidance factor, and the Rho GTPase machinery, controlling neuronal morphology and motility. In the second part of the review, we focus on glutamate-induced neuroplasticity and discuss the evidence on involvement of Rho and Ras GTPases in functional and structural synaptic plasticity triggered by the activation of glutamate receptors.
AB - Several neurotransmitters including serotonin and glutamate have been shown to be involved in many aspects of neural development, such as neurite outgrowth, regulation of neuronal morphology, growth cone motility and dendritic spine shape and density, in addition to their well-established role in neuronal communication. This review focuses on recent advances in our understanding of the molecular mechanisms underlying neurotransmitter-induced changes in neuronal morphology. In the first part of the review, we introduce the roles of small GTPases of the Rho family in morphogenic signaling in neurons and discuss signaling pathways, which may link serotonin, operating as a soluble guidance factor, and the Rho GTPase machinery, controlling neuronal morphology and motility. In the second part of the review, we focus on glutamate-induced neuroplasticity and discuss the evidence on involvement of Rho and Ras GTPases in functional and structural synaptic plasticity triggered by the activation of glutamate receptors.
M3 - SCORING: Zeitschriftenaufsatz
VL - 35
SP - 278
EP - 287
JO - MOL NEUROBIOL
JF - MOL NEUROBIOL
SN - 0893-7648
IS - 3
M1 - 3
ER -
