Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management.

  • R A Kyle
  • B G M Durie
  • S V Rajkumar
  • O Landgren
  • J Blade
  • G Merlini
  • Nicolaus Kröger
  • H Einsele
  • D H Vesole
  • M Dimopoulos
  • J San Miguel
  • H Avet-Loiseau
  • R Hajek
  • W M Chen
  • K C Anderson
  • H Ludwig
  • P Sonneveld
  • S Pavlovsky
  • A Palumbo
  • P G Richardson
  • B Barlogie
  • P Greipp
  • R Vescio
  • I Turesson
  • J Westin
  • M Boccadoro
  • International Myeloma Working Group

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) was identified in 3.2% of 21 463 residents of Olmsted County, Minnesota, 50 years of age or older. The risk of progression to multiple myeloma, Waldenstrom's macroglobulinemia, AL amyloidosis or a lymphoproliferative disorder is approximately 1% per year. Low-risk MGUS is characterized by having an M protein

Bibliographical data

Original languageGerman
Article number6
ISSN0887-6924
Publication statusPublished - 2010
pubmed 20410922