Monoclonal gammopathy of undetermined significance and Russell body formation in Helicobacter pylori gastritis
Standard
Monoclonal gammopathy of undetermined significance and Russell body formation in Helicobacter pylori gastritis. / Wolkersdörfer, Gernot W; Haase, Michael; Morgner, Andrea; Baretton, Gustavo; Miehlke, Stephan.
In: HELICOBACTER, Vol. 11, No. 5, 10.2006, p. 506-10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Monoclonal gammopathy of undetermined significance and Russell body formation in Helicobacter pylori gastritis
AU - Wolkersdörfer, Gernot W
AU - Haase, Michael
AU - Morgner, Andrea
AU - Baretton, Gustavo
AU - Miehlke, Stephan
PY - 2006/10
Y1 - 2006/10
N2 - BACKGROUND: Infection by Helicobacter pylori has been linked to monoclonal gammopathy of undetermined significance (MGUS). MGUS is thought to develop due to chronic antigenic stimulation in people with a specific genetic predisposition.METHODS AND RESULTS: We describe a patient presenting with dyspepsia associated with H. pylori-related erosive gastritis. Histopathologic findings revealed infiltration with plasma cells containing accumulated condensed intercisternal immunoglobulins, the so-called 'Russell bodies'. In addition, MGUS was present with total immunoglobulins within the normal range but a significantly decreased serum concentration of IgG subtype 3. Molecular analyses demonstrated IgH formation, T-cell receptor gamma rearrangement, and alterations within the IgHG3 gene sequence. Following H. pylori eradication, gastritis and dyspepsia gradually resolved but MGUS persisted for at least 22 months.CONCLUSIONS: This is the first report to demonstrate that upon infection with H. pylori, an impaired secretory capacity of plasma cells due to specific molecular changes can present as Russell body gastritis. The molecular findings question a pathogenetic link between Russell bodies and H. pylori, but suggest genetic alterations in the immunoglobulin locus as the possible cause for both MGUS and Russell body gastritis.
AB - BACKGROUND: Infection by Helicobacter pylori has been linked to monoclonal gammopathy of undetermined significance (MGUS). MGUS is thought to develop due to chronic antigenic stimulation in people with a specific genetic predisposition.METHODS AND RESULTS: We describe a patient presenting with dyspepsia associated with H. pylori-related erosive gastritis. Histopathologic findings revealed infiltration with plasma cells containing accumulated condensed intercisternal immunoglobulins, the so-called 'Russell bodies'. In addition, MGUS was present with total immunoglobulins within the normal range but a significantly decreased serum concentration of IgG subtype 3. Molecular analyses demonstrated IgH formation, T-cell receptor gamma rearrangement, and alterations within the IgHG3 gene sequence. Following H. pylori eradication, gastritis and dyspepsia gradually resolved but MGUS persisted for at least 22 months.CONCLUSIONS: This is the first report to demonstrate that upon infection with H. pylori, an impaired secretory capacity of plasma cells due to specific molecular changes can present as Russell body gastritis. The molecular findings question a pathogenetic link between Russell bodies and H. pylori, but suggest genetic alterations in the immunoglobulin locus as the possible cause for both MGUS and Russell body gastritis.
KW - Gastritis
KW - Helicobacter Infections
KW - Helicobacter pylori
KW - Humans
KW - Immunohistochemistry
KW - Inclusion Bodies
KW - Male
KW - Middle Aged
KW - Paraproteinemias
KW - Case Reports
KW - Journal Article
U2 - 10.1111/j.1523-5378.2006.00443.x
DO - 10.1111/j.1523-5378.2006.00443.x
M3 - SCORING: Journal article
C2 - 16961813
VL - 11
SP - 506
EP - 510
JO - HELICOBACTER
JF - HELICOBACTER
SN - 1083-4389
IS - 5
ER -