Monitoring Therapy Efficiency in Cancer through Extracellular Vesicles
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Monitoring Therapy Efficiency in Cancer through Extracellular Vesicles. / Stevic, Ines; Buescher, Gustav; Ricklefs, Franz Lennard.
In: CELLS-BASEL, Vol. 9, No. 1, 06.01.2020.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Monitoring Therapy Efficiency in Cancer through Extracellular Vesicles
AU - Stevic, Ines
AU - Buescher, Gustav
AU - Ricklefs, Franz Lennard
PY - 2020/1/6
Y1 - 2020/1/6
N2 - Extracellular vesicles (EVs) are a heterogeneous group of membrane-enclosed vesicles made of a phospholipid bilayer and are secreted by all cell types. EVs are present in a variety of body fluids containing proteins, DNA, RNA species, and lipids, and play an important role in cell- to-cell communication and are worth being considered as biomarkers for both early diagnosis of cancer patients and real-time monitoring of treatment response. Recently, emerging evidence verified EVs to have crucial roles in cancer progression and metastasis and a great potential in therapeutic applications. In this review, we discuss the potential of EVs in monitoring the efficacy of cancer therapies.
AB - Extracellular vesicles (EVs) are a heterogeneous group of membrane-enclosed vesicles made of a phospholipid bilayer and are secreted by all cell types. EVs are present in a variety of body fluids containing proteins, DNA, RNA species, and lipids, and play an important role in cell- to-cell communication and are worth being considered as biomarkers for both early diagnosis of cancer patients and real-time monitoring of treatment response. Recently, emerging evidence verified EVs to have crucial roles in cancer progression and metastasis and a great potential in therapeutic applications. In this review, we discuss the potential of EVs in monitoring the efficacy of cancer therapies.
U2 - 10.3390/cells9010130
DO - 10.3390/cells9010130
M3 - SCORING: Review article
C2 - 31935901
VL - 9
JO - CELLS-BASEL
JF - CELLS-BASEL
SN - 2073-4409
IS - 1
ER -