Monanchomycalin C, a new pentacyclic guanidine alkaloid from the far-eastern marine sponge Monanchora pulchra
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Monanchomycalin C, a new pentacyclic guanidine alkaloid from the far-eastern marine sponge Monanchora pulchra. / Tabakmakher, Ksenya M; Denisenko, Vladimir A; Guzii, Alla G; Dmitrenok, Pavel S; Dyshlovoy, Sergey A; Lee, Hyi-Seung; Makarieva, Tatyana N.
In: NAT PROD COMMUN, Vol. 8, No. 10, 10.2013, p. 1399-402.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Monanchomycalin C, a new pentacyclic guanidine alkaloid from the far-eastern marine sponge Monanchora pulchra
AU - Tabakmakher, Ksenya M
AU - Denisenko, Vladimir A
AU - Guzii, Alla G
AU - Dmitrenok, Pavel S
AU - Dyshlovoy, Sergey A
AU - Lee, Hyi-Seung
AU - Makarieva, Tatyana N
PY - 2013/10
Y1 - 2013/10
N2 - A new pentacyclic guanidine alkaloid, monanchomycalin C (1), along with the earlier known ptilomycalin A (2), were isolated from the Far-Eastern marine sponge Monanchora pulchra. The structure of 1 was elucidated using 1D and 2D NMR spectroscopic and ma ss spectrometric da ta. Compounds 1 and 2 exhibited cytotoxic activities against human breast cancer MDA-MB-231 cells with IC50 values of 8.2 microM and 4.3 pM, respectively.
AB - A new pentacyclic guanidine alkaloid, monanchomycalin C (1), along with the earlier known ptilomycalin A (2), were isolated from the Far-Eastern marine sponge Monanchora pulchra. The structure of 1 was elucidated using 1D and 2D NMR spectroscopic and ma ss spectrometric da ta. Compounds 1 and 2 exhibited cytotoxic activities against human breast cancer MDA-MB-231 cells with IC50 values of 8.2 microM and 4.3 pM, respectively.
KW - Animals
KW - Antineoplastic Agents
KW - Cell Line, Tumor
KW - Drug Screening Assays, Antitumor
KW - Guanidine
KW - Humans
KW - Molecular Structure
KW - Porifera
KW - Russia
M3 - SCORING: Journal article
C2 - 24354184
VL - 8
SP - 1399
EP - 1402
JO - NAT PROD COMMUN
JF - NAT PROD COMMUN
SN - 1934-578X
IS - 10
ER -