Monanchocidin
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Monanchocidin : a new apoptosis-inducing polycyclic guanidine alkaloid from the marine sponge Monanchora pulchra. / Guzii, Alla G; Makarieva, Tatyana N; Denisenko, Vladimir A; Dmitrenok, Pavel S; Kuzmich, Alexandra S; Dyshlovoy, Sergey A; Krasokhin, Vladimir B; Stonik, Valentin A.
In: ORG LETT, Vol. 12, No. 19, 01.10.2010, p. 4292-5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Monanchocidin
T2 - a new apoptosis-inducing polycyclic guanidine alkaloid from the marine sponge Monanchora pulchra
AU - Guzii, Alla G
AU - Makarieva, Tatyana N
AU - Denisenko, Vladimir A
AU - Dmitrenok, Pavel S
AU - Kuzmich, Alexandra S
AU - Dyshlovoy, Sergey A
AU - Krasokhin, Vladimir B
AU - Stonik, Valentin A
PY - 2010/10/1
Y1 - 2010/10/1
N2 - Monanchocidin (1), a guanidine alkaloid with an unprecedented skeleton system derived from a polyketide precursor, (ω-3)-hydroxy fatty acid, and containing a 2-aminoethyl- and 3-aminopropyl-substituted morpholine hemiketal ring, has been isolated from the sponge Monanhora pulchra. The structure of 1 was assigned on the basis of detailed analysis of 1D and 2D NMR spectra, mass spectrometry, and results of chemical transformations. Compound 1 shows pro-apoptotic and cytoxic activities.
AB - Monanchocidin (1), a guanidine alkaloid with an unprecedented skeleton system derived from a polyketide precursor, (ω-3)-hydroxy fatty acid, and containing a 2-aminoethyl- and 3-aminopropyl-substituted morpholine hemiketal ring, has been isolated from the sponge Monanhora pulchra. The structure of 1 was assigned on the basis of detailed analysis of 1D and 2D NMR spectra, mass spectrometry, and results of chemical transformations. Compound 1 shows pro-apoptotic and cytoxic activities.
KW - Animals
KW - Apoptosis
KW - Cell Line
KW - Guanidine
KW - Humans
KW - Mice
KW - Molecular Structure
KW - Oxidation-Reduction
KW - Porifera
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1021/ol101716x
DO - 10.1021/ol101716x
M3 - SCORING: Journal article
C2 - 20804151
VL - 12
SP - 4292
EP - 4295
JO - ORG LETT
JF - ORG LETT
SN - 1523-7060
IS - 19
ER -