Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas.

Marcel Kool; Andrey Korshunov; Marc Remke; David T W Jones; Maria Schlanstein; Paul A Northcott; Yoon-Jae Cho; Jan Koster; Schouten-van Meeteren Antoinette; Dannis van Vuurden; Steven C Clifford; Torsten Pietsch; André von Bueren; Stefan Rutkowski; Stefan Rutkowski; Martin McCabe; V Peter Collins; Magnus L Bäcklund; Christine Haberler; Franck Bourdeaut; Olivier Delattre; Francois Doz; David W Ellison; Richard J Gilbertson; Scott L Pomeroy; Michael D Taylor; Peter Lichter; Stefan M Pfister

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas.

Standard

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. / Kool, Marcel; Korshunov, Andrey; Remke, Marc; Jones, David T W; Schlanstein, Maria; Northcott, Paul A; Cho, Yoon-Jae; Koster, Jan; Antoinette, Schouten-van Meeteren; van Vuurden, Dannis; Clifford, Steven C; Pietsch, Torsten; von Bueren, André; Rutkowski, Stefan; Rutkowski, Stefan; McCabe, Martin; Collins, V Peter; Bäcklund, Magnus L; Haberler, Christine; Bourdeaut, Franck; Delattre, Olivier; Doz, Francois; Ellison, David W; Gilbertson, Richard J; Pomeroy, Scott L; Taylor, Michael D; Lichter, Peter; Pfister, Stefan M.

In: ACTA NEUROPATHOL, Vol. 123, No. 4, 4, 2012, p. 473-484.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kool, M, Korshunov, A, Remke, M, Jones, DTW, Schlanstein, M, Northcott, PA, Cho, Y-J, Koster, J, Antoinette, SM, van Vuurden, D, Clifford, SC, Pietsch, T, von Bueren, A, Rutkowski, S, Rutkowski, S, McCabe, M, Collins, VP, Bäcklund, ML, Haberler, C, Bourdeaut, F, Delattre, O, Doz, F, Ellison, DW, Gilbertson, RJ, Pomeroy, SL, Taylor, MD, Lichter, P & Pfister, SM 2012, 'Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas.', ACTA NEUROPATHOL, vol. 123, no. 4, 4, pp. 473-484. <http://www.ncbi.nlm.nih.gov/pubmed/22358457?dopt=Citation>

APA

Kool, M., Korshunov, A., Remke, M., Jones, D. T. W., Schlanstein, M., Northcott, P. A., Cho, Y-J., Koster, J., Antoinette, S. M., van Vuurden, D., Clifford, S. C., Pietsch, T., von Bueren, A., Rutkowski, S., Rutkowski, S., McCabe, M., Collins, V. P., Bäcklund, M. L., Haberler, C., ... Pfister, S. M. (2012). Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. ACTA NEUROPATHOL, 123(4), 473-484. [4]. http://www.ncbi.nlm.nih.gov/pubmed/22358457?dopt=Citation

Vancouver

Kool M, Korshunov A, Remke M, Jones DTW, Schlanstein M, Northcott PA et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. ACTA NEUROPATHOL. 2012;123(4):473-484. 4.

Bibtex

@article{a7a9b3ed9cd84f46b162924ebb647128,

title = "Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas.",

abstract = "Medulloblastoma is the most common malignant brain tumor in childhood. Molecular studies from several groups around the world demonstrated that medulloblastoma is not one disease but comprises a collection of distinct molecular subgroups. However, all these studies reported on different numbers of subgroups. The current consensus is that there are only four core subgroups, which should be termed WNT, SHH, Group 3 and Group 4. Based on this, we performed a meta-analysis of all molecular and clinical data of 550 medulloblastomas brought together from seven independent studies. All cases were analyzed by gene expression profiling and for most cases SNP or array-CGH data were available. Data are presented for all medulloblastomas together and for each subgroup separately. For validation purposes, we compared the results of this meta-analysis with another large medulloblastoma cohort (n = 402) for which subgroup information was obtained by immunohistochemistry. Results from both cohorts are highly similar and show how distinct the molecular subtypes are with respect to their transcriptome, DNA copy-number aberrations, demographics, and survival. Results from these analyses will form the basis for prospective multi-center studies and will have an impact on how the different subgroups of medulloblastoma will be treated in the future.",

keywords = "Adult, Humans, Male, Female, Adolescent, Young Adult, Multivariate Analysis, Cohort Studies, Child, Survival Analysis, Meta-Analysis as Topic, Child, Preschool, Age Distribution, Retrospective Studies, International Cooperation, Gene Expression Profiling, Microarray Analysis, Cytogenetics, *Chromosomes, Human, Pair 17, *Cerebellar Neoplasms/classification/diagnosis/genetics, *Chromosome Aberrations, *Chromosomes, Human, Pair 3, Gene Expression Regulation, Neoplastic/physiology, Hedgehog Proteins/genetics/metabolism, Kv1.1 Potassium Channel/genetics/metabolism, *Medulloblastoma/classification/diagnosis/genetics, Receptors, Atrial Natriuretic Factor/genetics/metabolism, *Transcriptome, Wnt Proteins/genetics/metabolism, Adult, Humans, Male, Female, Adolescent, Young Adult, Multivariate Analysis, Cohort Studies, Child, Survival Analysis, Meta-Analysis as Topic, Child, Preschool, Age Distribution, Retrospective Studies, International Cooperation, Gene Expression Profiling, Microarray Analysis, Cytogenetics, *Chromosomes, Human, Pair 17, *Cerebellar Neoplasms/classification/diagnosis/genetics, *Chromosome Aberrations, *Chromosomes, Human, Pair 3, Gene Expression Regulation, Neoplastic/physiology, Hedgehog Proteins/genetics/metabolism, Kv1.1 Potassium Channel/genetics/metabolism, *Medulloblastoma/classification/diagnosis/genetics, Receptors, Atrial Natriuretic Factor/genetics/metabolism, *Transcriptome, Wnt Proteins/genetics/metabolism",

author = "Marcel Kool and Andrey Korshunov and Marc Remke and Jones, {David T W} and Maria Schlanstein and Northcott, {Paul A} and Yoon-Jae Cho and Jan Koster and Antoinette, {Schouten-van Meeteren} and {van Vuurden}, Dannis and Clifford, {Steven C} and Torsten Pietsch and {von Bueren}, Andr{\'e} and Stefan Rutkowski and Stefan Rutkowski and Martin McCabe and Collins, {V Peter} and B{\"a}cklund, {Magnus L} and Christine Haberler and Franck Bourdeaut and Olivier Delattre and Francois Doz and Ellison, {David W} and Gilbertson, {Richard J} and Pomeroy, {Scott L} and Taylor, {Michael D} and Peter Lichter and Pfister, {Stefan M}",

year = "2012",

language = "English",

volume = "123",

pages = "473--484",

journal = "ACTA NEUROPATHOL",

issn = "0001-6322",

publisher = "Springer",

number = "4",

}

RIS

TY - JOUR

T1 - Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas.

AU - Kool, Marcel

AU - Korshunov, Andrey

AU - Remke, Marc

AU - Jones, David T W

AU - Schlanstein, Maria

AU - Northcott, Paul A

AU - Cho, Yoon-Jae

AU - Koster, Jan

AU - Antoinette, Schouten-van Meeteren

AU - van Vuurden, Dannis

AU - Clifford, Steven C

AU - Pietsch, Torsten

AU - von Bueren, André

AU - Rutkowski, Stefan

AU - McCabe, Martin

AU - Collins, V Peter

AU - Bäcklund, Magnus L

AU - Haberler, Christine

AU - Bourdeaut, Franck

AU - Delattre, Olivier

AU - Doz, Francois

AU - Ellison, David W

AU - Gilbertson, Richard J

AU - Pomeroy, Scott L

AU - Taylor, Michael D

AU - Lichter, Peter

AU - Pfister, Stefan M

PY - 2012

Y1 - 2012

N2 - Medulloblastoma is the most common malignant brain tumor in childhood. Molecular studies from several groups around the world demonstrated that medulloblastoma is not one disease but comprises a collection of distinct molecular subgroups. However, all these studies reported on different numbers of subgroups. The current consensus is that there are only four core subgroups, which should be termed WNT, SHH, Group 3 and Group 4. Based on this, we performed a meta-analysis of all molecular and clinical data of 550 medulloblastomas brought together from seven independent studies. All cases were analyzed by gene expression profiling and for most cases SNP or array-CGH data were available. Data are presented for all medulloblastomas together and for each subgroup separately. For validation purposes, we compared the results of this meta-analysis with another large medulloblastoma cohort (n = 402) for which subgroup information was obtained by immunohistochemistry. Results from both cohorts are highly similar and show how distinct the molecular subtypes are with respect to their transcriptome, DNA copy-number aberrations, demographics, and survival. Results from these analyses will form the basis for prospective multi-center studies and will have an impact on how the different subgroups of medulloblastoma will be treated in the future.

AB - Medulloblastoma is the most common malignant brain tumor in childhood. Molecular studies from several groups around the world demonstrated that medulloblastoma is not one disease but comprises a collection of distinct molecular subgroups. However, all these studies reported on different numbers of subgroups. The current consensus is that there are only four core subgroups, which should be termed WNT, SHH, Group 3 and Group 4. Based on this, we performed a meta-analysis of all molecular and clinical data of 550 medulloblastomas brought together from seven independent studies. All cases were analyzed by gene expression profiling and for most cases SNP or array-CGH data were available. Data are presented for all medulloblastomas together and for each subgroup separately. For validation purposes, we compared the results of this meta-analysis with another large medulloblastoma cohort (n = 402) for which subgroup information was obtained by immunohistochemistry. Results from both cohorts are highly similar and show how distinct the molecular subtypes are with respect to their transcriptome, DNA copy-number aberrations, demographics, and survival. Results from these analyses will form the basis for prospective multi-center studies and will have an impact on how the different subgroups of medulloblastoma will be treated in the future.

KW - Adult

KW - Humans

KW - Male

KW - Female

KW - Adolescent

KW - Young Adult

KW - Multivariate Analysis

KW - Cohort Studies

KW - Child

KW - Survival Analysis

KW - Meta-Analysis as Topic

KW - Child, Preschool

KW - Age Distribution

KW - Retrospective Studies

KW - International Cooperation

KW - Gene Expression Profiling

KW - Microarray Analysis

KW - Cytogenetics

KW - Chromosomes, Human, Pair 17

KW - Cerebellar Neoplasms/classification/diagnosis/genetics

KW - Chromosome Aberrations

KW - Chromosomes, Human, Pair 3

KW - Gene Expression Regulation, Neoplastic/physiology

KW - Hedgehog Proteins/genetics/metabolism

KW - Kv1.1 Potassium Channel/genetics/metabolism

KW - Medulloblastoma/classification/diagnosis/genetics

KW - Receptors, Atrial Natriuretic Factor/genetics/metabolism

KW - Transcriptome

KW - Wnt Proteins/genetics/metabolism