Molecular evidence for relapse of an imported Plasmodium ovale wallikeri infection

Luzia Veletzky; Mirjam Groger; Heimo Lagler; Julia Walochnik; Herbert Auer; Hans-Peter Fuehrer; Michael Ramharter

doi:10.1186/s12936-018-2226-4

Molecular evidence for relapse of an imported Plasmodium ovale wallikeri infection

Standard

Molecular evidence for relapse of an imported Plasmodium ovale wallikeri infection. / Veletzky, Luzia; Groger, Mirjam; Lagler, Heimo; Walochnik, Julia; Auer, Herbert; Fuehrer, Hans-Peter; Ramharter, Michael.

In: MALARIA J, Vol. 17, 09.02.2018, p. 78.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Veletzky, L, Groger, M, Lagler, H, Walochnik, J, Auer, H, Fuehrer, H-P & Ramharter, M 2018, 'Molecular evidence for relapse of an imported Plasmodium ovale wallikeri infection', MALARIA J, vol. 17, pp. 78. https://doi.org/10.1186/s12936-018-2226-4

APA

Veletzky, L., Groger, M., Lagler, H., Walochnik, J., Auer, H., Fuehrer, H-P., & Ramharter, M. (2018). Molecular evidence for relapse of an imported Plasmodium ovale wallikeri infection. MALARIA J, 17, 78. https://doi.org/10.1186/s12936-018-2226-4

Vancouver

Veletzky L, Groger M, Lagler H, Walochnik J, Auer H, Fuehrer H-P et al. Molecular evidence for relapse of an imported Plasmodium ovale wallikeri infection. MALARIA J. 2018 Feb 9;17:78. https://doi.org/10.1186/s12936-018-2226-4

Bibtex

@article{dee167d04a9a410d9cf4b62c7b5b74a3,

title = "Molecular evidence for relapse of an imported Plasmodium ovale wallikeri infection",

abstract = "BACKGROUND: Malaria caused by Plasmodium ovale spp. has been neglected by and large from research and has received only little scientific attention during the past decades. Ovale malaria is considered to feature relapses by liver hypnozoites although scientific evidence for this paradigm is scarce.CASE PRESENTATION: Here, the case of a 16-year-old male, who presented with fevers to the outpatient department in Vienna, Austria, after travelling to Uganda and Papua New Guinea is described. Infection with Plasmodium malariae was diagnosed by microscopy and the patient was treated accordingly with a full course of supervised artemether-lumefantrine. He was discharged in good clinical condition with a negative blood smear. One month after initial diagnosis, he returned complaining of fever. Thick blood smear was positive again for malaria parasites, which were confirmed as P. ovale wallikeri by PCR. Retrospective analysis revealed the identical Plasmodium spp. in the initial blood samples. Molecular analysis of various gene loci (nuclear porbp2, 18S rRNA and potra genes) gave identical results providing further evidence for relapse by an identical parasite genotype. Consecutively, the patient was retreated with artemether-lumefantrine and received a regimen of primaquine according to WHO guidelines.CONCLUSION: Conclusive evidence for relapses with P. ovale spp. is rare. The presented case provides convincing confirmation for the relapse paradigm based on re-appearing parasitaemia following supervised treatment in a non-endemic region with a parasite strain of identical genotype.",

keywords = "Adolescent, Antimalarials, Artemether, Lumefantrine Drug Combination, Austria, Communicable Diseases, Imported, Humans, Malaria, Male, Papua New Guinea, Plasmodium ovale, Primaquine, Recurrence, Secondary Prevention, Uganda, Case Reports, Journal Article",

author = "Luzia Veletzky and Mirjam Groger and Heimo Lagler and Julia Walochnik and Herbert Auer and Hans-Peter Fuehrer and Michael Ramharter",

year = "2018",

month = feb,

day = "9",

doi = "10.1186/s12936-018-2226-4",

language = "English",

volume = "17",

pages = "78",

journal = "MALARIA J",

issn = "1475-2875",

publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Molecular evidence for relapse of an imported Plasmodium ovale wallikeri infection

AU - Veletzky, Luzia

AU - Groger, Mirjam

AU - Lagler, Heimo

AU - Walochnik, Julia

AU - Auer, Herbert

AU - Fuehrer, Hans-Peter

AU - Ramharter, Michael

PY - 2018/2/9

Y1 - 2018/2/9

N2 - BACKGROUND: Malaria caused by Plasmodium ovale spp. has been neglected by and large from research and has received only little scientific attention during the past decades. Ovale malaria is considered to feature relapses by liver hypnozoites although scientific evidence for this paradigm is scarce.CASE PRESENTATION: Here, the case of a 16-year-old male, who presented with fevers to the outpatient department in Vienna, Austria, after travelling to Uganda and Papua New Guinea is described. Infection with Plasmodium malariae was diagnosed by microscopy and the patient was treated accordingly with a full course of supervised artemether-lumefantrine. He was discharged in good clinical condition with a negative blood smear. One month after initial diagnosis, he returned complaining of fever. Thick blood smear was positive again for malaria parasites, which were confirmed as P. ovale wallikeri by PCR. Retrospective analysis revealed the identical Plasmodium spp. in the initial blood samples. Molecular analysis of various gene loci (nuclear porbp2, 18S rRNA and potra genes) gave identical results providing further evidence for relapse by an identical parasite genotype. Consecutively, the patient was retreated with artemether-lumefantrine and received a regimen of primaquine according to WHO guidelines.CONCLUSION: Conclusive evidence for relapses with P. ovale spp. is rare. The presented case provides convincing confirmation for the relapse paradigm based on re-appearing parasitaemia following supervised treatment in a non-endemic region with a parasite strain of identical genotype.

AB - BACKGROUND: Malaria caused by Plasmodium ovale spp. has been neglected by and large from research and has received only little scientific attention during the past decades. Ovale malaria is considered to feature relapses by liver hypnozoites although scientific evidence for this paradigm is scarce.CASE PRESENTATION: Here, the case of a 16-year-old male, who presented with fevers to the outpatient department in Vienna, Austria, after travelling to Uganda and Papua New Guinea is described. Infection with Plasmodium malariae was diagnosed by microscopy and the patient was treated accordingly with a full course of supervised artemether-lumefantrine. He was discharged in good clinical condition with a negative blood smear. One month after initial diagnosis, he returned complaining of fever. Thick blood smear was positive again for malaria parasites, which were confirmed as P. ovale wallikeri by PCR. Retrospective analysis revealed the identical Plasmodium spp. in the initial blood samples. Molecular analysis of various gene loci (nuclear porbp2, 18S rRNA and potra genes) gave identical results providing further evidence for relapse by an identical parasite genotype. Consecutively, the patient was retreated with artemether-lumefantrine and received a regimen of primaquine according to WHO guidelines.CONCLUSION: Conclusive evidence for relapses with P. ovale spp. is rare. The presented case provides convincing confirmation for the relapse paradigm based on re-appearing parasitaemia following supervised treatment in a non-endemic region with a parasite strain of identical genotype.

KW - Adolescent

KW - Antimalarials

KW - Artemether, Lumefantrine Drug Combination

KW - Austria

KW - Communicable Diseases, Imported

KW - Humans

KW - Malaria

KW - Male

KW - Papua New Guinea

KW - Plasmodium ovale

KW - Primaquine

KW - Recurrence

KW - Secondary Prevention

KW - Uganda

KW - Case Reports

KW - Journal Article

U2 - 10.1186/s12936-018-2226-4

DO - 10.1186/s12936-018-2226-4

M3 - SCORING: Journal article

C2 - 29426330

VL - 17

SP - 78

JO - MALARIA J

JF - MALARIA J

SN - 1475-2875

ER -