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Molecular Characterization and Clinical Description of Non-Polio Enteroviruses Detected in Stool Samples from HIV-Positive and HIV-Negative Adults in Ghana

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Molecular Characterization and Clinical Description of Non-Polio Enteroviruses Detected in Stool Samples from HIV-Positive and HIV-Negative Adults in Ghana. / Di Cristanziano, Veronica; Weimer, Kristina; Böttcher, Sindy; Sarfo, Fred Stephen; Dompreh, Albert; Cesar, Lucio-Garcia; Knops, Elena; Heger, Eva; Wirtz, Maike; Kaiser, Rolf; Norman, Betty; Phillips, Richard Odame; Feldt, Torsten; Eberhardt, Kirsten Alexandra.

In: VIRUSES-BASEL, Vol. 12, No. 2, 16.02.2020, p. 221.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Di Cristanziano, V, Weimer, K, Böttcher, S, Sarfo, FS, Dompreh, A, Cesar, L-G, Knops, E, Heger, E, Wirtz, M, Kaiser, R, Norman, B, Phillips, RO, Feldt, T & Eberhardt, KA 2020, 'Molecular Characterization and Clinical Description of Non-Polio Enteroviruses Detected in Stool Samples from HIV-Positive and HIV-Negative Adults in Ghana', VIRUSES-BASEL, vol. 12, no. 2, pp. 221. https://doi.org/10.3390/v12020221

APA

Di Cristanziano, V., Weimer, K., Böttcher, S., Sarfo, F. S., Dompreh, A., Cesar, L-G., Knops, E., Heger, E., Wirtz, M., Kaiser, R., Norman, B., Phillips, R. O., Feldt, T., & Eberhardt, K. A. (2020). Molecular Characterization and Clinical Description of Non-Polio Enteroviruses Detected in Stool Samples from HIV-Positive and HIV-Negative Adults in Ghana. VIRUSES-BASEL, 12(2), 221. https://doi.org/10.3390/v12020221

Vancouver

Di Cristanziano V, Weimer K, Böttcher S, Sarfo FS, Dompreh A, Cesar L-G et al. Molecular Characterization and Clinical Description of Non-Polio Enteroviruses Detected in Stool Samples from HIV-Positive and HIV-Negative Adults in Ghana. VIRUSES-BASEL. 2020 Feb 16;12(2):221. https://doi.org/10.3390/v12020221

Bibtex

@article{f117dc005bd348fda74fc5f87373e941,
title = "Molecular Characterization and Clinical Description of Non-Polio Enteroviruses Detected in Stool Samples from HIV-Positive and HIV-Negative Adults in Ghana",
abstract = "In the post-polio eradication era, increasing attention is given to non-polio enteroviruses. Most of the data about enteroviruses in sub-Saharan Africa are related to acute flaccid paralysis surveillance and target the pediatric population. This study aimed to investigate the presence of enterovirus in PLHIV (people living with HIV) and HIV-negative individuals in Ghana. Stool samples from HIV-positive individuals (n = 250) and healthy blood donors (n = 102) attending the Komfo Anokye Teaching Hospital in Kumasi, Ghana, were screened by real-time PCR for enterovirus. Molecular typing of the VP1 region was performed. Enterovirus-positive samples were tested for norovirus, adenovirus, rotavirus, sapovirus, and cosaviruses. Twenty-six out of 250 HIV-positive subjects (10.4%) and 14 out of 102 HIV-negative individuals (13.7%) were detected enterovirus-positive, not showing a significant different infection rate between the two groups. HIV-negative individuals were infected with Enterovirus C strains only. HIV-positive participants were detected positive for species Enterovirus A, Enterovirus B, and Enterovirus C. Co-infections with other viral enteric pathogens were almost exclusively detected among HIV-positive participants. Overall, the present study provides the first data about enteroviruses within HIV-positive and HIV-negative adults living in Ghana.",
author = "{Di Cristanziano}, Veronica and Kristina Weimer and Sindy B{\"o}ttcher and Sarfo, {Fred Stephen} and Albert Dompreh and Lucio-Garcia Cesar and Elena Knops and Eva Heger and Maike Wirtz and Rolf Kaiser and Betty Norman and Phillips, {Richard Odame} and Torsten Feldt and Eberhardt, {Kirsten Alexandra}",
year = "2020",
month = feb,
day = "16",
doi = "10.3390/v12020221",
language = "English",
volume = "12",
pages = "221",
journal = "VIRUSES-BASEL",
issn = "1999-4915",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",

}

RIS

TY - JOUR

T1 - Molecular Characterization and Clinical Description of Non-Polio Enteroviruses Detected in Stool Samples from HIV-Positive and HIV-Negative Adults in Ghana

AU - Di Cristanziano, Veronica

AU - Weimer, Kristina

AU - Böttcher, Sindy

AU - Sarfo, Fred Stephen

AU - Dompreh, Albert

AU - Cesar, Lucio-Garcia

AU - Knops, Elena

AU - Heger, Eva

AU - Wirtz, Maike

AU - Kaiser, Rolf

AU - Norman, Betty

AU - Phillips, Richard Odame

AU - Feldt, Torsten

AU - Eberhardt, Kirsten Alexandra

PY - 2020/2/16

Y1 - 2020/2/16

N2 - In the post-polio eradication era, increasing attention is given to non-polio enteroviruses. Most of the data about enteroviruses in sub-Saharan Africa are related to acute flaccid paralysis surveillance and target the pediatric population. This study aimed to investigate the presence of enterovirus in PLHIV (people living with HIV) and HIV-negative individuals in Ghana. Stool samples from HIV-positive individuals (n = 250) and healthy blood donors (n = 102) attending the Komfo Anokye Teaching Hospital in Kumasi, Ghana, were screened by real-time PCR for enterovirus. Molecular typing of the VP1 region was performed. Enterovirus-positive samples were tested for norovirus, adenovirus, rotavirus, sapovirus, and cosaviruses. Twenty-six out of 250 HIV-positive subjects (10.4%) and 14 out of 102 HIV-negative individuals (13.7%) were detected enterovirus-positive, not showing a significant different infection rate between the two groups. HIV-negative individuals were infected with Enterovirus C strains only. HIV-positive participants were detected positive for species Enterovirus A, Enterovirus B, and Enterovirus C. Co-infections with other viral enteric pathogens were almost exclusively detected among HIV-positive participants. Overall, the present study provides the first data about enteroviruses within HIV-positive and HIV-negative adults living in Ghana.

AB - In the post-polio eradication era, increasing attention is given to non-polio enteroviruses. Most of the data about enteroviruses in sub-Saharan Africa are related to acute flaccid paralysis surveillance and target the pediatric population. This study aimed to investigate the presence of enterovirus in PLHIV (people living with HIV) and HIV-negative individuals in Ghana. Stool samples from HIV-positive individuals (n = 250) and healthy blood donors (n = 102) attending the Komfo Anokye Teaching Hospital in Kumasi, Ghana, were screened by real-time PCR for enterovirus. Molecular typing of the VP1 region was performed. Enterovirus-positive samples were tested for norovirus, adenovirus, rotavirus, sapovirus, and cosaviruses. Twenty-six out of 250 HIV-positive subjects (10.4%) and 14 out of 102 HIV-negative individuals (13.7%) were detected enterovirus-positive, not showing a significant different infection rate between the two groups. HIV-negative individuals were infected with Enterovirus C strains only. HIV-positive participants were detected positive for species Enterovirus A, Enterovirus B, and Enterovirus C. Co-infections with other viral enteric pathogens were almost exclusively detected among HIV-positive participants. Overall, the present study provides the first data about enteroviruses within HIV-positive and HIV-negative adults living in Ghana.

U2 - 10.3390/v12020221

DO - 10.3390/v12020221

M3 - SCORING: Journal article

C2 - 32079128

VL - 12

SP - 221

JO - VIRUSES-BASEL

JF - VIRUSES-BASEL

SN - 1999-4915

IS - 2

ER -