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Molecular and functional characterization of polymorphisms in the secreted phospholipase A2 group X gene: relevance to coronary artery disease

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Molecular and functional characterization of polymorphisms in the secreted phospholipase A2 group X gene: relevance to coronary artery disease. / Gora, Sarah; Perret, Claire; Jemel, Ikram; Nicaud, Viviane; Lambeau, Gérard; Cambien, François; Ninio, Ewa; Blankenberg, Stefan; Tiret, Laurence; Karabina, Sonia-Athina.

In: J MOL MED, Vol. 87, No. 7, 07.2009, p. 723-733.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gora, S, Perret, C, Jemel, I, Nicaud, V, Lambeau, G, Cambien, F, Ninio, E, Blankenberg, S, Tiret, L & Karabina, S-A 2009, 'Molecular and functional characterization of polymorphisms in the secreted phospholipase A2 group X gene: relevance to coronary artery disease', J MOL MED, vol. 87, no. 7, pp. 723-733. https://doi.org/10.1007/s00109-009-0483-y

APA

Gora, S., Perret, C., Jemel, I., Nicaud, V., Lambeau, G., Cambien, F., Ninio, E., Blankenberg, S., Tiret, L., & Karabina, S-A. (2009). Molecular and functional characterization of polymorphisms in the secreted phospholipase A2 group X gene: relevance to coronary artery disease. J MOL MED, 87(7), 723-733. https://doi.org/10.1007/s00109-009-0483-y

Vancouver

Gora S, Perret C, Jemel I, Nicaud V, Lambeau G, Cambien F et al. Molecular and functional characterization of polymorphisms in the secreted phospholipase A2 group X gene: relevance to coronary artery disease. J MOL MED. 2009 Jul;87(7):723-733. https://doi.org/10.1007/s00109-009-0483-y

Bibtex

@article{463afd1bf307403e80b510a7e932649f,
title = "Molecular and functional characterization of polymorphisms in the secreted phospholipase A2 group X gene: relevance to coronary artery disease",
abstract = "Among secreted phospholipases A2 (sPLA2s), human group X sPLA2 (hGX sPLA2) is emerging as a novel attractive therapeutic target due to its implication in inflammatory diseases. To elucidate whether hGX sPLA2 plays a causative role in coronary artery disease (CAD), we screened the human PLA2G10 gene to identify polymorphisms and possible associations with CAD end-points in a prospective study, AtheroGene. We identified eight polymorphisms, among which, one non-synonymous polymorphism R38C in the propeptide region of the sPLA2. The T-512C polymorphism located in the 5' untranslated region was associated with a decreased risk of recurrent cardiovascular events during follow-up. The functional analysis of the R38C polymorphism showed that it leads to a profound change in expression and activity of hGX sPLA2, although there was no detectable impact on CAD risk. Due to the potential role of hGX sPLA2 in inflammatory processes, these polymorphisms should be investigated in other inflammatory diseases.",
keywords = "5' Untranslated Regions/genetics, Adult, Aged, Coronary Artery Disease/enzymology, Female, Fluoroimmunoassay, Genetic Predisposition to Disease/genetics, Group X Phospholipases A2/genetics, Humans, Immunohistochemistry, Male, Microscopy, Confocal, Middle Aged, Mutagenesis, Site-Directed, Polymorphism, Genetic/genetics",
author = "Sarah Gora and Claire Perret and Ikram Jemel and Viviane Nicaud and G{\'e}rard Lambeau and Fran{\c c}ois Cambien and Ewa Ninio and Stefan Blankenberg and Laurence Tiret and Sonia-Athina Karabina",
year = "2009",
month = jul,
doi = "10.1007/s00109-009-0483-y",
language = "English",
volume = "87",
pages = "723--733",
journal = "J MOL MED",
issn = "0946-2716",
publisher = "Springer",
number = "7",

}

RIS

TY - JOUR

T1 - Molecular and functional characterization of polymorphisms in the secreted phospholipase A2 group X gene: relevance to coronary artery disease

AU - Gora, Sarah

AU - Perret, Claire

AU - Jemel, Ikram

AU - Nicaud, Viviane

AU - Lambeau, Gérard

AU - Cambien, François

AU - Ninio, Ewa

AU - Blankenberg, Stefan

AU - Tiret, Laurence

AU - Karabina, Sonia-Athina

PY - 2009/7

Y1 - 2009/7

N2 - Among secreted phospholipases A2 (sPLA2s), human group X sPLA2 (hGX sPLA2) is emerging as a novel attractive therapeutic target due to its implication in inflammatory diseases. To elucidate whether hGX sPLA2 plays a causative role in coronary artery disease (CAD), we screened the human PLA2G10 gene to identify polymorphisms and possible associations with CAD end-points in a prospective study, AtheroGene. We identified eight polymorphisms, among which, one non-synonymous polymorphism R38C in the propeptide region of the sPLA2. The T-512C polymorphism located in the 5' untranslated region was associated with a decreased risk of recurrent cardiovascular events during follow-up. The functional analysis of the R38C polymorphism showed that it leads to a profound change in expression and activity of hGX sPLA2, although there was no detectable impact on CAD risk. Due to the potential role of hGX sPLA2 in inflammatory processes, these polymorphisms should be investigated in other inflammatory diseases.

AB - Among secreted phospholipases A2 (sPLA2s), human group X sPLA2 (hGX sPLA2) is emerging as a novel attractive therapeutic target due to its implication in inflammatory diseases. To elucidate whether hGX sPLA2 plays a causative role in coronary artery disease (CAD), we screened the human PLA2G10 gene to identify polymorphisms and possible associations with CAD end-points in a prospective study, AtheroGene. We identified eight polymorphisms, among which, one non-synonymous polymorphism R38C in the propeptide region of the sPLA2. The T-512C polymorphism located in the 5' untranslated region was associated with a decreased risk of recurrent cardiovascular events during follow-up. The functional analysis of the R38C polymorphism showed that it leads to a profound change in expression and activity of hGX sPLA2, although there was no detectable impact on CAD risk. Due to the potential role of hGX sPLA2 in inflammatory processes, these polymorphisms should be investigated in other inflammatory diseases.

KW - 5' Untranslated Regions/genetics

KW - Adult

KW - Aged

KW - Coronary Artery Disease/enzymology

KW - Female

KW - Fluoroimmunoassay

KW - Genetic Predisposition to Disease/genetics

KW - Group X Phospholipases A2/genetics

KW - Humans

KW - Immunohistochemistry

KW - Male

KW - Microscopy, Confocal

KW - Middle Aged

KW - Mutagenesis, Site-Directed

KW - Polymorphism, Genetic/genetics

U2 - 10.1007/s00109-009-0483-y

DO - 10.1007/s00109-009-0483-y

M3 - SCORING: Journal article

C2 - 19495570

VL - 87

SP - 723

EP - 733

JO - J MOL MED

JF - J MOL MED

SN - 0946-2716

IS - 7

ER -