Modulation of bovine chondrocyte metabolism by free periosteal grafts in vitro.
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Modulation of bovine chondrocyte metabolism by free periosteal grafts in vitro. / Steinhagen, Jörn; Niggemeyer, Oliver; Bruns, Jürgen; Klebig, Florian; Fuerst, Martin; Rüther, Wolfgang; Schuenke, Michael; Kurz, Bodo.
In: INT J ARTIF ORGANS, Vol. 35, No. 2, 2, 2012, p. 108-118.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Modulation of bovine chondrocyte metabolism by free periosteal grafts in vitro.
AU - Steinhagen, Jörn
AU - Niggemeyer, Oliver
AU - Bruns, Jürgen
AU - Klebig, Florian
AU - Fuerst, Martin
AU - Rüther, Wolfgang
AU - Schuenke, Michael
AU - Kurz, Bodo
PY - 2012
Y1 - 2012
N2 - Autologous chondrocyte transplantation (ACT) is an established method in cartilage repair. Although long-term results show durable repair of isolated cartilage defects, some problems still remain. Since hypertrophy of the transplanted periosteum is a common problem, alternatives for periosteum are in demand. Periosteal grafts have been reported to stimulate neochondrogenesis via paracrine effects. The objective of this study was to evaluate the modulation of chondrocyte metabolism by periosteal grafts in vitro.
AB - Autologous chondrocyte transplantation (ACT) is an established method in cartilage repair. Although long-term results show durable repair of isolated cartilage defects, some problems still remain. Since hypertrophy of the transplanted periosteum is a common problem, alternatives for periosteum are in demand. Periosteal grafts have been reported to stimulate neochondrogenesis via paracrine effects. The objective of this study was to evaluate the modulation of chondrocyte metabolism by periosteal grafts in vitro.
KW - Animals
KW - Immunohistochemistry
KW - Time Factors
KW - Cells, Cultured
KW - Cattle
KW - Coculture Techniques
KW - Cell Proliferation
KW - Paracrine Communication
KW - DNA Replication
KW - Aggrecans/biosynthesis
KW - Chondrocytes/metabolism
KW - Chondrogenesis
KW - Collagen Type II/biosynthesis
KW - Periosteum/cytology/metabolism
KW - Proline/metabolism
KW - Animals
KW - Immunohistochemistry
KW - Time Factors
KW - Cells, Cultured
KW - Cattle
KW - Coculture Techniques
KW - Cell Proliferation
KW - Paracrine Communication
KW - DNA Replication
KW - Aggrecans/biosynthesis
KW - Chondrocytes/metabolism
KW - Chondrogenesis
KW - Collagen Type II/biosynthesis
KW - Periosteum/cytology/metabolism
KW - Proline/metabolism
M3 - SCORING: Journal article
VL - 35
SP - 108
EP - 118
JO - INT J ARTIF ORGANS
JF - INT J ARTIF ORGANS
SN - 0391-3988
IS - 2
M1 - 2
ER -