Moderater Alkoholkonsum und Plasmakonzentration sensitiver Entzündungsmarker. Hinweise auf einen atheroprotektiven Zusammenhang
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Moderater Alkoholkonsum und Plasmakonzentration sensitiver Entzündungsmarker. Hinweise auf einen atheroprotektiven Zusammenhang. / Hoffmeister, A; Imhof, Armin; Rothenbacher, D; Khuseyinova, N; Brenner, H; Koenig, W.
In: DEUT MED WOCHENSCHR, Vol. 128, No. 43, 24.10.2003, p. 2237-41.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research
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TY - JOUR
T1 - Moderater Alkoholkonsum und Plasmakonzentration sensitiver Entzündungsmarker. Hinweise auf einen atheroprotektiven Zusammenhang
AU - Hoffmeister, A
AU - Imhof, Armin
AU - Rothenbacher, D
AU - Khuseyinova, N
AU - Brenner, H
AU - Koenig, W
PY - 2003/10/24
Y1 - 2003/10/24
N2 - BACKGROUND AND OBJECTIVE: Changes in lipoproteins and hemostasis only incompletely explain the reduced cardiovascular mortality associated with light to moderate alcohol consumption. Since increasing evidence suggests that atherosclerosis can be considered to be a chronic inflammatory process, we sought to assess the association between daily alcohol consumption and levels of sensitive markers of inflammation.STUDY PARTICIPANTS AND METHODS: 478 voluntary blood donors (358 men, 120 women) aged 40 to 68 years were categorized into four groups according to their self-reported amount of daily alcohol consumption: 0 g/day, >0 - 20 g/day, >20 - 40 g/day, and > 40 g/day. Means of various sensitive markers of inflammation (C-reactive protein (CRP), serum amyloid A (SAA), interleukin-6 (IL-6), intercellular adhesion molecule-1, plasma viscosity und albumin) were calculated and compared by bivariate and multivariate analyses.RESULTS: More than 80 % of the study participants reported to consume alcohol, mainly beer. We found statistically significantly decreased levels of SAA, CRP, and plasma viscosity in subjects with light-to-moderate alcohol intake (>0 - 20 g/day and > 20 - 40 g/day, respectively), and a trend for increased levels of albumin in these subjects compared to non-drinkers. After multivariable adjustment for potential confounders (age, gender, body mass index, cigarette smoking, years of school education, and physical activity) a significant U-shaped association (p = 0.02) between levels of SAA and the amount of daily alcohol intake remained: there were 0.75 mg/l and 0.70 mg/l lower mean levels, respectively, of SAA in subjects with light-to-moderate alcohol intake compared to those of non-drinkers. Subjects with an alcohol intake of > 40 grams per day showed a statistically significant increase in levels of interleukin-6 (0.50 pg/ml) compared to non-drinkers.CONCLUSION: Potential anti-inflammatory properties of moderate alcohol consumption might represent an additional mechanism to explain its atheroprotective effect.
AB - BACKGROUND AND OBJECTIVE: Changes in lipoproteins and hemostasis only incompletely explain the reduced cardiovascular mortality associated with light to moderate alcohol consumption. Since increasing evidence suggests that atherosclerosis can be considered to be a chronic inflammatory process, we sought to assess the association between daily alcohol consumption and levels of sensitive markers of inflammation.STUDY PARTICIPANTS AND METHODS: 478 voluntary blood donors (358 men, 120 women) aged 40 to 68 years were categorized into four groups according to their self-reported amount of daily alcohol consumption: 0 g/day, >0 - 20 g/day, >20 - 40 g/day, and > 40 g/day. Means of various sensitive markers of inflammation (C-reactive protein (CRP), serum amyloid A (SAA), interleukin-6 (IL-6), intercellular adhesion molecule-1, plasma viscosity und albumin) were calculated and compared by bivariate and multivariate analyses.RESULTS: More than 80 % of the study participants reported to consume alcohol, mainly beer. We found statistically significantly decreased levels of SAA, CRP, and plasma viscosity in subjects with light-to-moderate alcohol intake (>0 - 20 g/day and > 20 - 40 g/day, respectively), and a trend for increased levels of albumin in these subjects compared to non-drinkers. After multivariable adjustment for potential confounders (age, gender, body mass index, cigarette smoking, years of school education, and physical activity) a significant U-shaped association (p = 0.02) between levels of SAA and the amount of daily alcohol intake remained: there were 0.75 mg/l and 0.70 mg/l lower mean levels, respectively, of SAA in subjects with light-to-moderate alcohol intake compared to those of non-drinkers. Subjects with an alcohol intake of > 40 grams per day showed a statistically significant increase in levels of interleukin-6 (0.50 pg/ml) compared to non-drinkers.CONCLUSION: Potential anti-inflammatory properties of moderate alcohol consumption might represent an additional mechanism to explain its atheroprotective effect.
KW - Adult
KW - Aged
KW - Alcohol Drinking/blood
KW - Arteriosclerosis/blood
KW - Biomarkers/blood
KW - Blood Viscosity
KW - C-Reactive Protein/analysis
KW - Confounding Factors, Epidemiologic
KW - Female
KW - Humans
KW - Inflammation/blood
KW - Intercellular Adhesion Molecule-1/blood
KW - Interleukin-6/blood
KW - Male
KW - Middle Aged
KW - Multivariate Analysis
KW - Serum Albumin/analysis
KW - Serum Amyloid A Protein/analysis
U2 - 10.1055/s-2003-43101
DO - 10.1055/s-2003-43101
M3 - SCORING: Zeitschriftenaufsatz
C2 - 14574636
VL - 128
SP - 2237
EP - 2241
JO - DEUT MED WOCHENSCHR
JF - DEUT MED WOCHENSCHR
SN - 0012-0472
IS - 43
ER -
